本文選題：多囊卵巢綜合征 + 尿促性素��； 參考：《中國全科醫(yī)學(xué)》2017年S1期

【摘要】：目的探討尿促性素(HMG)聯(lián)合枸櫞酸氯米芬(CC)對(duì)多囊卵巢綜合征(PCOS)患者排卵周期、子宮內(nèi)膜、卵泡情況、激素、卵巢過度刺激綜合征及妊娠的影響。方法選取2012年6月—2015年6月溫州醫(yī)學(xué)院附屬第三醫(yī)院婦產(chǎn)科收治的160例PCOS患者,按照隨機(jī)數(shù)字表的方法將所有患者分為研究組和對(duì)照組。對(duì)照組給予CC,研究組在此基礎(chǔ)上給予HMG。比較兩種治療方案對(duì)患者排卵周期、子宮內(nèi)膜、卵泡情況、激素、卵巢過度刺激綜合征及妊娠的影響。結(jié)果研究組患者的子宮內(nèi)膜厚度和成熟卵泡數(shù)均高于對(duì)照組(t=21.939,9.778,P0.05);兩組患者的最大卵泡直徑、有排卵周期數(shù)比較,差異無統(tǒng)計(jì)學(xué)意義(t=0.812,χ~2=2.609,P0.05);研究組患者的雌二醇(E2)水平高于對(duì)照組(t=3.567,P0.05);兩組患者的黃體生成激素(LH)以及睪酮(T)的水平比較,差異無統(tǒng)計(jì)學(xué)意義(t=0.539,0.599,P0.05);研究組患者的平均用藥周期短于對(duì)照組(P0.05)、臨床妊娠率高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者的流產(chǎn)率、多胎妊娠率、OHSS發(fā)生率比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 HMG聯(lián)合CC治療PCOS,用藥周期短,促排卵效果顯著,具有較高的臨床妊娠率,值得推廣應(yīng)用。
[Abstract]:Objective to investigate the effects of urinal gonadotropin (HMG) combined with clomiphene citrate (CCC) on ovulation cycle, endometrium, follicle status, hormones, ovarian hyperstimulation syndrome and pregnancy in patients with polycystic ovary syndrome (PCOS). Methods from June 2012 to June 2015, 160 patients with PCOS in gynecology and obstetrics department of the third affiliated Hospital of Wenzhou Medical College were randomly divided into study group and control group. The control group was given CCS, and the study group was given HMG-based. The effects of two treatments on ovulation cycle, endometrium, follicle status, hormones, ovarian hyperstimulation syndrome and pregnancy were compared. Results the thickness of endometrium and the number of mature follicles in the study group were higher than those in the control group (21.939 ~ 9.778g / P 0.05), the maximum follicle diameter and the number of ovulation cycles were compared between the two groups. The level of estradiol E _ 2 in the study group was higher than that in the control group, and the levels of luteinizing hormone (LH) and testosterone (T) in the two groups were higher than those in the control group, the difference was not significant (P = 0.812), and the level of estradiol E _ (2) in the study group was higher than that in the control group (P _ (0.05). There was no significant difference between the two groups (P 0.05). The average period of medication in the study group was shorter than that in the control group (P 0.05), and the clinical pregnancy rate was higher than that in the control group (P 0.05). The abortion rate and the multiple pregnancy rate of the two groups were higher than those of the control group, and the incidence of OHSS was higher than that of the control group. The difference was not statistically significant (P 0.05). Conclusion the combination of HMG and CC in the treatment of PCOS has the advantages of short medication cycle, obvious effect of ovulation promotion, and high clinical pregnancy rate, which is worth popularizing.
【作者單位】： 溫州醫(yī)學(xué)院附屬第三醫(yī)院;溫州醫(yī)科大學(xué)附屬第一醫(yī)院;
【分類號(hào)】：R711.75

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