發(fā)布時間：2018-04-21 13:16

  本文選題：糖尿病足 + 難愈性創(chuàng)面��； 參考：《山西醫(yī)科大學》2015年碩士論文

【摘要】：目的:同藥物選擇,治療糖尿病足難愈性創(chuàng)面,觀察創(chuàng)面愈合情況,探討治療糖尿病足難愈性創(chuàng)面新方法。方法:將120例符合入選標準的糖尿病足患者按隨機數字表法分為:空白對照組(A組)、小劑量胰島素組(B組)、GM-CSF組(C組)和小計量胰島素+GM-CSF組(D組),每組30例。因主、客觀原因導致研究對象無法繼續(xù)臨床實驗的剔除后,最終進入統(tǒng)計分析的病例數對照組29例,小劑量胰島素組28例,GM-CSF組27例,胰島素+GM-CSF組28例。觀察治療后3、15、26、40、51天的創(chuàng)面愈合情況。結果:1.創(chuàng)面愈合總體情況:D組在創(chuàng)面愈合過程中分泌物與其余三個組比較量少且相對清潔,創(chuàng)面愈合率在第、15、26、40、51天均高于其余三組,具有統(tǒng)計學差異(P0.05);2.各組創(chuàng)面完全上皮化時間分別為A組(105.5±1.4)d,B組(76.3±1.9)d,C組(75.6±2.0)d,D組(49.3±1.7)d,其中D組愈合時間低于其余兩個實驗組,且遠低于空白對照組,各組間差異具有統(tǒng)計意義(P0.05);3.通過比較糖尿病臨床分級這一因素發(fā)現(xiàn),臨床分級越高,所需愈合時間越長。結論:小劑量胰島素聯(lián)合人類重組粒細胞-巨噬細胞集落刺激因子(rh GM-CSF)的使用,能夠更好的治療糖尿病足難愈性創(chuàng)面。
[Abstract]:Objective: to treat the refractory wound of diabetic foot, observe the healing of wound and explore a new method for treating refractory wound of diabetic foot. Methods: one hundred and twenty patients with diabetic foot were randomly divided into three groups: control group (n = 30), control group (n = 30), small dose insulin group (n = 30), small dose insulin group (n = 30) and small dose insulin GM-CSF group (n = 30). Because of subjective and objective reasons, 29 cases in the control group, 27 cases in the GM-CSF group and 28 cases in the insulin GM-CSF group were involved in the statistical analysis. The wound healing was observed in 3 days after treatment. The result is 1: 1. The general situation of wound healing in group D was less and cleaner than that of the other three groups in the wound healing process. The wound healing rate in group D was higher than that in the other three groups at day 1526, 4051, with statistical difference (P 0.05). The time of complete epithelization of wounds in each group was 76.3 鹵1.9 d in group A and 105.5 鹵1.4 days in group B, respectively. The healing time of group D was lower than that of the other two experimental groups, and was much lower than that of the control group (P 0.053d). By comparing the clinical grade of diabetes, it was found that the higher the clinical grade, the longer the healing time. Conclusion: low dose insulin combined with human recombinant granulocyte-macrophage colony stimulating factor rh GM-CSF can better treat refractory wound of diabetic foot.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R587.2

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