本文選題：高原反應 + 紅細胞形態(tài)�。� 參考：《中國輸血雜志》2017年08期

【摘要】：目的探討高原環(huán)境下人體外周血紅細胞形態(tài)與高原反應的關系,為高原反應的預防和治療提供實驗依據(jù)。方法設急進高原組:世居海拔約500 m平原地區(qū)的受試者25名,分別于其急進高原前后采集外周血血樣各5m L/(人)份;久居高原組:受試者14名,居住在海拔約3 600 m地區(qū)10年,包括世居高原的藏族人7名、居住高原10-15年的漢族人7名,采集其外周血血樣5 m L/(人)份;調(diào)查2組的高原反應發(fā)生情況,掃描電鏡觀察2組受試者紅細胞形態(tài),統(tǒng)計分析2組受試者不同形態(tài)紅細胞數(shù)量。結果在海拔約3 200及3 600 m高原地區(qū),急進高原組均出現(xiàn)不同程度的高原反應,久居高原組則無高原反應情況發(fā)生。正常形態(tài)的外周血紅細胞數(shù)量(個/份):急進高原組急進高原前后分別為471.43±1.35(海拔約500 m)、263.31±6.16(海拔約3 200 m)、256.29±13.03(海拔約3 600m)(P0.01),且畸形紅細胞數(shù)量明顯增加;久居高原組為368.57±11.26,明顯高于急進高原組(P0.01),且畸形紅細胞數(shù)量明顯低于急進高原組。久居高原組中藏族和漢族人群的正常形態(tài)的外周血紅細胞數(shù)量相近(P0.05)。結論正常健康成年人急進高原后,外周血紅細胞的畸形化改變可能是高原反應發(fā)生的機理之一。
[Abstract]:Objective to study the relationship between erythrocyte morphology of human peripheral blood and altitude reaction in high altitude environment, and to provide experimental basis for prevention and treatment of altitude reaction.Methods A total of 25 subjects living at an altitude of about 500 m were divided into two groups: 25 subjects were collected blood samples from peripheral blood before and after they entered the plateau, and 14 subjects lived at altitude of about 3 600 m for 10 years.There were 7 Tibetans who lived on the plateau and 7 Han people who lived on the plateau for 10-15 years. The peripheral blood samples were collected from 7 Tibetans and 7 Han people living on the plateau. The occurrence of plateau reaction in the two groups was investigated, and the erythrocyte morphology of the two groups was observed by scanning electron microscope.The number of erythrocytes of different morphology in two groups were analyzed statistically.Results in the altitude of about 3 200 m and 3 600 m above sea level, there were different degrees of high altitude reaction in the rapid entry plateau group, but there was no high altitude reaction in the long lived plateau group.The number of normal peripheral blood red blood cells was 471.43 鹵1.35 (about 263.31 鹵6.16) before and after the rapid entry at high altitude (about 256.29 鹵13.03 above sea level), and the number of abnormal red blood cells increased significantly.The number of abnormal red blood cells in the long-lived high altitude group was 368.57 鹵11.26, which was significantly higher than that in the acute plateau group (P 0.01), and the number of abnormal red blood cells was significantly lower than that in the acute plateau group.The number of normal peripheral blood red blood cells in Tibetan and Han population was similar to that of P0.05 in plateau group for a long time.Conclusion the abnormal changes of peripheral blood red blood cells in healthy adults may be one of the mechanisms of altitude reaction.
【作者單位】： 第四軍醫(yī)大學西京醫(yī)院輸血科;空軍總醫(yī)院;
【分類號】：R594.3

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