本文選題：胰高血糖素樣肽-1 + 白色脂肪細(xì)胞棕色化��； 參考：《河北醫(yī)科大學(xué)》2017年碩士論文

【摘要】：脂肪組織因功能不同而分為棕色脂肪組織(BAT)和白色脂肪組織(WAT);BAT主要作用是氧化脂肪釋放熱量,而WAT以脂肪儲存為主,WAT含量顯著增多是肥胖的主要特征。在一定外界環(huán)境刺激下,WAT可以向BAT轉(zhuǎn)化,從而改善體內(nèi)能量代謝,降低體重,該過程稱為“白色脂肪細(xì)胞棕色化”。新型降糖藥物胰高血糖素樣肽-1(glucagon-like peptide-1,GLP-1)受體激動劑在降低血糖的同時,也能有效減輕體質(zhì)量。以往研究證實(shí)其減重作用與抑制食欲,減少食物攝入和延緩胃排空有關(guān)。然而新近有研究發(fā)現(xiàn)GLP-1受體激動劑還可以通過加強(qiáng)BAT功能及增加BAT數(shù)量,達(dá)到減重的目的。本文將對GLP-1促進(jìn)白色脂肪細(xì)胞棕色化的作用機(jī)制作一簡單綜述。
[Abstract]:Adipose tissue is divided into brown adipose tissue and white adipose tissue due to their different functions. The main function of fat is to release calories from oxidized fat, and the increase of fat storage in WAT is the main characteristic of obesity.Under certain external environment, WAT can be transformed into BAT, which can improve energy metabolism and reduce body weight. This process is called "brown white fat cells".Glucagon-like peptide-1 (GLP-1) receptor agonist of glucagon-like peptide-1 (GLP-1), a new hypoglycemic drug, can reduce blood glucose and reduce body mass.Previous studies have shown that weight loss is related to appetite suppression, food intake reduction and gastric emptying.However, recent studies have found that GLP-1 receptor agonists can also reduce weight by enhancing the function of BAT and increasing the number of BAT.In this review, the mechanism of GLP-1 promoting the browning of white adipocytes is reviewed.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R589.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 鄭曉彬;艾鶴英;袁淑華;曹歡易;梁華;翁建平;徐芬;;SIRT1基因缺陷對肥胖小鼠棕色脂肪功能的影響[J];中華醫(yī)學(xué)雜志;2016年23期

2 沈山梅;石歡;畢艷;馮文煥;王維敏;金璽;韓小娟;胡明s，

本文編號：1756853