本文選題：55歲以上男性 + 肌少癥　； 參考：《首都醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的通過(guò)檢測(cè)北京地區(qū)55歲以上男性糖尿病肌少癥患者與糖尿病肌量正�；颊叩乃闹趋兰≠|(zhì)量(appendicular skeletal muscle mass,ASM)、骨密度(bone mineral density,BMD)及相關(guān)因素,調(diào)查中老年男性2型糖尿病(Type 2 diabetes mellitus,T2DM)患者肌少癥(Sarcopenia)的患病情況,探討2型糖尿病患者骨骼肌肉質(zhì)量減少與骨密度的相關(guān)性,促進(jìn)健康生活習(xí)慣的養(yǎng)成,實(shí)現(xiàn)對(duì)中老年T2DM患者肌少癥及骨質(zhì)疏松癥的二級(jí)預(yù)防和早期干預(yù)方法選取首都醫(yī)科大學(xué)宣武醫(yī)院內(nèi)分泌科2016年5月至12月,119名55-87歲男性T2DM住院患者,記錄受試者一般情況,用雙光能X線(xiàn)吸收儀測(cè)量腰椎、左側(cè)股骨頸、右側(cè)股骨頸BMD,ASM,四肢脂肪含量(appendicular fat mass,AFM)等,計(jì)算出四肢骨骼肌質(zhì)量指數(shù)(appendicular skeletal musclemass index,ASMI),通過(guò)測(cè)量握力方法評(píng)價(jià)肌力,采用6米步行測(cè)試評(píng)估受試者的軀體功能,采用1998年Baumgartner診斷標(biāo)準(zhǔn)定義肌少癥。采用線(xiàn)性相關(guān)分析方法統(tǒng)計(jì)ASM、AFM、ASMI、肌力等與BMD的相關(guān)性,采用Logistic回歸分析統(tǒng)計(jì)肌少癥與骨質(zhì)疏松癥的相關(guān)性。結(jié)果1、北京地區(qū)55歲以上男性T2DM患者肌少癥檢出率為28.57%,低骨骼肌含量(ASMI7.26kg/m2)的55歲以上男性T2DM患者BMD明顯低于非低骨骼肌含量(ASMI≥7.26kg/m2)者。2、相關(guān)分析顯示ASMI與腰椎BMD及左、右股骨頸BMD均成正相關(guān),T2DM低骨骼肌含量受試者患骨質(zhì)疏松癥的風(fēng)險(xiǎn)明顯增加,是T2DM非低骨骼肌含量受試者的3.067倍(OR=3.067,95%CI:1.023～9.190,P=0.045)。結(jié)論北京地區(qū)55歲以上男性T2DM患者的骨骼肌質(zhì)量減少與骨質(zhì)疏松癥密切相關(guān)。中老年男性T2DM患者應(yīng)及時(shí)進(jìn)行肌少癥及骨質(zhì)疏松癥的早期篩查以實(shí)現(xiàn)早期預(yù)防和及時(shí)干預(yù)。
[Abstract]:Objective to investigate the Beijing area men over the age of 55 diabetic patients with normal muscle in patients with diabetes and less muscle mass limbs skeletal muscle mass (appendicular skeletal muscle mass, ASM), bone mineral density (bone mineral density, BMD) and related factors among elderly men with type 2 diabetes mellitus (Type 2 diabetes mellitus, T2DM) in patients with muscle less disease (Sarcopenia) prevalence of skeletal muscle in patients with type 2 diabetes to reduce the quality of correlation with bone density, promote healthy lifestyle, to achieve two levels of prevention and early intervention methods less disease and osteoporosis in elderly patients with T2DM muscle from Capital Medical University Xuanwu Hospital Department of endocrinology from May 2016 to December, 119 A 55-87 year old male patients with T2DM were recorded in general, measured by dual energy X-ray absorption of lumbar spine, left femoral neck, right femoral neck bone BMD, ASM, limb fat containing The amount of (appendicular fat mass, AFM), calculate the limb skeletal muscle mass index (appendicular skeletal musclemass index, ASMI), by measuring the grip strength evaluation method of strength, the 6 meter walk test subjects were evaluated by the physical function, the 1998 Baumgartner diagnostic standard definition of sarcopenia. Using correlation analysis method of linear statistics ASM AFM, ASMI, and BMD, correlation of muscle strength, using Logistic correlation analysis statistical sarcopenia and osteoporosis. The regression results in 1, the Beijing area over 55 years old male T2DM patients with sarcopenia detection rate was 28.57%, the low content of skeletal muscle (ASMI7.26kg/m2) of the 55 men over the age of T2DM patients was significantly lower than that of non BMD low content of skeletal muscle (ASMI = 7.26kg/m2).2, correlation analysis showed that ASMI and BMD of the lumbar spine and left and right femoral neck BMD were positively related to T2DM risk, low content of skeletal muscle in subjects suffering from osteoporosis increased significantly, T2DM is 3.067 times of non low skeletal muscle content of subjects (OR=3.067,95%CI:1.023 ~ 9.190, P=0.045). 55 years old male T2DM patients in Beijing conclusion skeletal muscle mass reduction is closely related with osteoporosis. T2DM in elderly male patients should be early screening of sarcopenia and osteoporosis in order to achieve early the prevention and timely intervention.

【學(xué)位授予單位】：首都醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R587.1;R685

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本文編號(hào)：1746901