本文選題：型糖尿病 + 輕度認知障礙��； 參考：《山東醫(yī)藥》2017年27期

【摘要】：目的觀察維生素D口服輔助治療2型糖尿病伴輕度認知功能障礙的效果。方法 2型糖尿病伴輕度認知功能障礙患者60例,隨機分為對照組和治療組各30例。對照組在飲食指導、生活方式指導、運動和血糖控制的基礎(chǔ)上口服奧拉西坦膠囊800 mg/次,3次/d,連續(xù)服用24周。治療組在對照組基礎(chǔ)上,口服維生素D滴劑(膠囊型)2粒,連續(xù)服用24周。兩組分別于治療前和治療4、12、24周時檢測血清25-羥基維生素D_3[25(OH)D_3]濃度,采用蒙特利爾認知評價量表(MoCA)評分評價認知功能,檢測空腹血糖(FPG)、空腹胰島素(FPI)、糖化血紅蛋白(HbA_(1c))并計算胰島素抵抗指數(shù)(HOMA-IR),用藥期間觀察藥物不良反應(yīng)和低血糖發(fā)生情況。結(jié)果治療組治療4、12、24周時血清25(OH)D_3均高于治療前(P均0.05),且治療12、24周時血清25(OH)D_3水平高于對照組(P均0.01)。治療組治療12、24周時MoCA評分高于治療前(P均0.01),治療24周時MoCA評分高于對照組(P0.05)。治療組治療12、24周時FPG、HbA_(1c)低于治療前,治療24周時FPI、HOMA-IR低于治療前(P均0.05);治療組治療24周時FPG、FPI、HbA_(1c)、HOMA-IR均低于對照組(P均0.05)。兩組患者治療過程中血常規(guī)、肝腎功能、電解質(zhì)、尿常規(guī)等均未出現(xiàn)明顯異常。治療組2例出現(xiàn)食欲減退和便秘癥狀,均在數(shù)日后自行緩解。兩組均未出現(xiàn)低血糖癥狀。結(jié)論維生素D口服輔助治療2型糖尿病伴輕度認知功能障礙可改善患者的認知功能,并有助于控制血糖和糾正胰島素抵抗,用藥安全性較好。
[Abstract]:Objective To observe the effect of oral vitamin D assisted with mild cognitive dysfunction in type 2 diabetes therapy. Methods of type 2 diabetes patients with mild cognitive impairment in patients with 60 cases, were randomly divided into control group and treatment group with 30 cases in each group. The control group in the diet guidance, life guidance, exercise and blood glucose control on oral administration of Oxiracetam Capsules 800 mg/ times. 3 /d, administered for 24 weeks. The treatment group on the basis of the control group, oral vitamin D drops (capsule) 2 capsules administered for 24 weeks. The two groups respectively before treatment and 4,12,24 weeks serum 25- hydroxyvitamin D_3[25 (OH) D_3] concentration, using the Montreal cognitive assessment scale (MoCA) the score of cognitive function evaluation, fasting blood glucose (FPG), fasting insulin (FPI), glycosylated hemoglobin (HbA_ (1c)) and insulin resistance index (HOMA-IR), medication during the observation of adverse reactions and hypoglycemia drugs. 鍐，

本文編號：1743382