本文選題：類風濕關節(jié)炎 + 表觀遺傳學��； 參考：《中國免疫學雜志》2017年04期

【摘要】：正類風濕關節(jié)炎(Rheumatoid arthritis,RA)是一種自身免疫性疾病,以慢性滑膜炎為主要病理改變,臨床表現(xiàn)為關節(jié)疼痛腫脹、關節(jié)損傷和活動受限,最終會導致關節(jié)破壞和殘疾。以抗瓜氨酸化抗體(Citrullinated peptide antigens,ACPA)是否陽性來劃分,RA可以被劃分為ACPA+和ACPA-兩大類~([1])。ACPA+的RA患者與特定的HLAⅡ類等位基因相關。多項全基因組關聯(lián)分析(Genome-wide association studies,GWAS)已經(jīng)確認遺傳變異在不同群體
[Abstract]:Rheumatoid arthritis (RA) is an autoimmune disease, with chronic synovitis as the main pathological change. The clinical manifestations are joint pain swelling, joint injury and limited movement, which will eventually lead to joint destruction and disability.According to whether the anti citrullinated peptide antigensus ACPA is positive or not, RA can be divided into two groups: ACPA and ACPA- ([1] .ACPA.) the patients with RA are associated with specific HLA class 鈪，

本文編號：1740763