本文選題：殼聚糖　切入點：高脂膳食　出處：《食品與機械》2017年04期

【摘要】：為研究不同分子量殼聚糖對高脂膳食小鼠血糖的調(diào)節(jié)作用,選取C57BL/6J雄性小鼠48只,隨機分為4組:正常組(Control)、高脂組(high fat,HF)、低分子量殼聚糖組(high fat+low weight molecular chitosan,HF+LWMC)和高分子量殼聚糖組(high fat+high weight molecular chitosan,HF+HWMC)。每周記錄其攝食量和體重。飼養(yǎng)16周后,對小鼠血清、肝臟的生化指標進行測定,并對肝臟磷酸烯醇式丙酮酸(Phosphoenolpyruvate carboxybinase,PEPCK)及葡萄糖-6-磷酸酶(Glucose 6phosphatase,G6Pase)的基因表達進行檢測。結果表明:殼聚糖的添加可降低高脂膳食小鼠的體重和血脂水平,緩解肝臟脂質(zhì)過氧化,高分子量殼聚糖的效果略好于低分子量殼聚糖。
[Abstract]:In order to study the effect of chitosan with different molecular weight on blood glucose in high-fat diet mice, 48 male C57BL/6J mice were selected.They were randomly divided into 4 groups: normal group, high fat group, high fat low weight molecular chitosan group and high fat high weight molecular chitosan group.Food intake and weight were recorded weekly.After 16 weeks of feeding, the biochemical indexes of serum and liver of mice were determined, and the gene expression of Phosphoenolpyruvate carboxybinase (PEPCK) and glucose-6-phosphatase (Glucose 6phosphatase- G6 Pase) in liver were determined.The results showed that the addition of chitosan could reduce the body weight and blood lipid level of mice with high fat diet and alleviate the lipid peroxidation of liver. The effect of high molecular weight chitosan was better than that of low molecular weight chitosan.
【作者單位】： 江南大學食品學院;食品科學與技術國家重點實驗室;江蘇海隆國際貿(mào)易有限公司;
【基金】：中國博士后科學基金(編號:2015M581726) 江蘇省博士后科研資助計劃(編號:1501099C) 江南大學自主科研計劃青年基金(編號:JUSRP11551) 江蘇省自然科學基金青年基金(編號:BK20160170) “江蘇省食品安全與質(zhì)量控制協(xié)同創(chuàng)新中心”項目
【分類號】：R459.3;R587.1
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本文編號：1723960