本文選題：皮質(zhì)醇增多癥　切入點：脆性組氨酸三聯(lián)體　出處：《重慶醫(yī)學》2016年05期

【摘要】：目的探討皮質(zhì)醇增多癥腎上腺皮質(zhì)不同病變中脆性組氨酸三聯(lián)體(FHIT)、Ki-67及增殖細胞核抗原(PCNA)的表達水平及其在鑒別診斷中的作用。方法應用免疫組織化學方法檢測49例皮質(zhì)醇增多癥腎上腺皮質(zhì)病變(腺癌14例、腺瘤26例、皮質(zhì)增生9例)患者FHIT、Ki-67及PCNA的表達。結(jié)果 FHIT在腎上腺皮質(zhì)增生表達最高,腺瘤次之,腺癌最低(分別為100.00%、96.15%、42.86%);Ki-67與PCNA在腎上腺皮質(zhì)腺癌的表達最高,腺瘤次之,皮質(zhì)增生最低(分別為85.71%、7.69%、0和100.00%、96.15%、77.78%)。FHIT、Ki-67及PCNA在皮質(zhì)醇增多癥腎上腺皮質(zhì)病變中的表達兩兩相關,其中FHIT與Ki-67表達呈負相關(r=-0.718,P=0.00),FHIT與PCNA表達呈負相關(r=-0.449,P=0.001),Ki-67與PCNA表達呈正相關(r=0.387,P=0.006)。聯(lián)合檢測FHIT、Ki67及PCNA結(jié)果顯示,腺癌表現(xiàn)為FHIT陰性或弱陽性、Ki-67強陽性、PCNA強陽性;腺瘤表現(xiàn)為FHIT陽性、Ki-67陽性、PCNA陽性;皮質(zhì)增生表現(xiàn)為FHIT強陽性、Ki-67陰性、PCNA陰性。結(jié)論聯(lián)合檢測FHIT、Ki-67及PCNA對腎上腺皮質(zhì)腺癌、腺瘤及增生的鑒別診斷具有重要的價值。
[Abstract]:Objective to investigate the expression level of FHITK Ki-67 and proliferating cell nuclear antigen (PCNA) in different lesions of adrenal cortex in patients with corticostosis and their role in differential diagnosis.Methods Immunohistochemical method was used to detect the expression of FHITKi-67 and PCNA in 49 patients with adrenal cortical lesions (adenocarcinoma 14, adenoma 26, cortical hyperplasia 9).Results the expression of FHIT was the highest in adrenocortical hyperplasia, followed by adenoma, and the lowest in adenocarcinoma (100.00,96.15). Ki-67 and PCNA were the highest in adrenal cortical adenocarcinoma, followed by adenoma.鐨川澧炵敓鏈，

本文編號：1703125