本文選題：補腎壯骨顆粒　切入點：有氧運動　出處：《中國骨質疏松雜志》2017年06期

【摘要】：目的探討有氧運動與補腎壯骨顆粒綜合療法治療絕經后骨質疏松癥(postmenopausal osteoporosis,PMOP)的療效及機理,為有效防治PMOP提供理論依據。方法采用去勢大鼠模型,分為假手術組(n=10)、模型組(n=10)、陽性組(n=10)、有氧運動組(n=10)、補腎壯骨顆粒組(n=10)和聯(lián)合組(n=10),去勢后2 w運用有氧運動、補腎壯骨顆粒以及二者聯(lián)合等干預方法防治大鼠發(fā)生的骨質疏松。連續(xù)12 w檢測各組大鼠骨組織生物力學,同時采用實時熒光定量PCR技術檢測骨代謝相關指標表達。結果與假手術組相比,模型組大鼠的左股骨最大負荷、左脛骨最大負荷和第四腰椎結構強度均顯著降低(P0.05)。與模型組相比,陽性組、有氧運動組、補腎壯骨顆粒組和聯(lián)合組的左股骨最大負荷、左脛骨最大負荷和第四腰椎結構強度均顯著提高(P0.05)。熒光定量PCR結果顯示,與模型組相比,陽性組、有氧運動組、補腎壯骨顆粒組和聯(lián)合組的RANKL和OPG均顯著提高(P0.05),而RANKL/OPG顯著降低(P0.05)。與陽性組相比,聯(lián)合干預組的RANKL和OPG均顯著提高(P0.05),而RANKL/OPG顯著降低(P0.05)。結論補腎壯骨顆粒和運動的綜合性治療策略能通過降低骨組織中OPG/RANKL比值,進而抑制破骨細胞的活性來改善去勢大鼠骨質疏松癥病情,其療效要優(yōu)于單純運動及補腎壯骨顆粒。
[Abstract]:Objective to explore the therapeutic effect and mechanism of aerobic exercise and Bushen Zhuanggu granule in treating postmenopausal osteoporosis (PMOP), and to provide theoretical basis for effective prevention and treatment of PMOP. Methods Ovariectomized rat model was used. They were divided into sham operation group, model group, positive group, aerobic exercise group, Bushen Zhuanggu granule group and combined group. Aerobic exercise was used 2 weeks after castration. Bushen Zhuanggu granule and its combination were used to prevent and treat osteoporosis in rats. Biomechanics of bone tissue in each group was detected for 12 weeks. At the same time, real-time fluorescence quantitative PCR was used to detect the expression of bone metabolism related indexes. Results compared with sham operation group, the maximal load of left femur in model group was higher than that in sham operation group. The maximum load of left tibia and the strength of the fourth lumbar vertebrae decreased significantly compared with the model group, the maximal load of left femur in positive group, aerobic exercise group, Bushen Zhuanggu granule group and combined group. The maximum load of left tibia and the structural strength of the fourth lumbar vertebra increased significantly. The results of fluorescence quantitative PCR showed that, compared with the model group, positive group, aerobic exercise group, Both RANKL and OPG in Bushen Zhuanggu granule group and combined group were significantly increased, while RANKL/OPG significantly decreased P0.05. In the combined intervention group, both RANKL and OPG increased significantly, while RANKL/OPG significantly decreased P0.05.Conclusion the comprehensive treatment strategy of Bushen Zhuanggu granule and exercise can reduce the ratio of OPG/RANKL in bone tissue. And then inhibit the activity of osteoclasts to improve the condition of osteoporosis in ovariectomized rats, its curative effect is better than simple exercise and Bushen Zhuanggu granule.
【作者單位】： 青海省西寧市第一人民醫(yī)院;大連醫(yī)科大學附屬第一醫(yī)院婦科;
【分類號】：R580

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1 鄧偉民,沈有高,賀揚淑,韋蒿;補腎壯骨顆粒與聯(lián)合激素替代療法對骨代謝生化指標的影響(英文)[J];中國臨床康復;2004年17期

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本文編號：1677230