本文選題：艾滋病病毒　切入點(diǎn)：原發(fā)性耐藥　出處：《中南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年06期

【摘要】：目的:了解男男同性戀(men who have sex with men,MSM)艾滋病原發(fā)性耐藥及耐藥基因突變位點(diǎn)現(xiàn)狀。方法:檢索CNKI,VIP,CBM,萬(wàn)方數(shù)據(jù)庫(kù),Pub Med,Web of Knowledge,Springer及Medline數(shù)據(jù)庫(kù),提取HIV耐藥以及耐藥基因突變位點(diǎn)數(shù)據(jù),對(duì)效應(yīng)量進(jìn)行合并,并對(duì)樣本量、地區(qū)、人種、質(zhì)量評(píng)價(jià)得分及采樣時(shí)間進(jìn)行亞組分析。結(jié)果:共納入43篇文獻(xiàn),MSM未治療HIV感染者總耐藥率、蛋白酶抑制劑(proteinase inhibitors,PI)耐藥率、核苷類(lèi)反轉(zhuǎn)錄酶抑制劑(nucleoside reverse transcriptase inhibitors,NRTI)耐藥率、非核苷類(lèi)反轉(zhuǎn)錄酶抑制劑(non nucleoside reverse transcriptase inhibitors,NNRTI)耐藥率分別為10.21%(95%CI:8.65%~12.03%),2.98%(95%CI:2.25%~3.93%),4.05%(95%CI:3.14%~5.21%),4.42%(95%CI:3.31%~5.88%)。PI主要突變位點(diǎn)、PI次要突變位點(diǎn)、NRTI突變位點(diǎn)、NNRTI突變位點(diǎn)的突變位點(diǎn)頻數(shù)≥3的突變率分別為0.55%(95%CI:0.38%~0.80%),1.31%(95%CI:0.98%~1.75%),0.85%(95%CI:0.51%~1.40%),1.19%(95%CI:0.70%~2.01%);頻數(shù)3的突變率分別為0.79%(95%CI:0.55%~1.13%),1.73%(95%CI:1.21%~2.46%),0.86%(95%CI:0.61%~1.21%),2.24%(95%CI:1.77%~2.83%)。樣本量、地區(qū)及人種均是異質(zhì)性的來(lái)源,耐藥率和基因突變位點(diǎn)突變率在不同的亞組中分布不同。結(jié)論:美洲、歐洲地區(qū)MSM原發(fā)性耐藥率較高,亞洲地區(qū)較以往也有所升高;同時(shí)PI次要突變位點(diǎn)突變率亦較高,應(yīng)引起重視。
[Abstract]:Objective: to investigate the status of who have sex with with mutation in HIV / AIDS. Methods: the data of HIV resistance and drug resistance gene mutation sites were extracted from the database of who have sex with with. Methods: the data of HIV drug resistance and drug resistance gene mutation were retrieved from the database of who have sex with. Methods: the data of HIV drug resistance and drug resistance gene mutation were retrieved from the database of Pub Medweb of Knowledgestringer Springer and Medline. The subgroup analysis of sample size, region, race, quality evaluation score and sampling time was carried out. Results: total drug resistance rate and protease inhibitor inhibitor PI- resistance rate were analyzed in 43 articles. Nucleoside reverse transcriptase inhibitors NRTI, a nucleoside reverse transcriptase inhibitor, showed high drug resistance. Non nucleoside reverse transcriptase inhibitor NNRTI) resistance rates were 10.2195 / 95CI8.65CI2.98 / 2.98C 2.933.95 / 4.053.05 / 95 / 95 CI: 4.422i. The percentage of NRTI mutation frequency 鈮，

本文編號(hào)：1656342