本文選題：紅斑狼瘡　切入點：系統(tǒng)性　出處：《南昌大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:分析系統(tǒng)性紅斑狼瘡(systemic lupus erythematosus,SLE)患者血液系統(tǒng)受累的特點,并探討其臨床意義。方法:按照國家風(fēng)濕病數(shù)據(jù)中心要求收集并分析334例SLE患者的臨床資料,將患者分為有血液系統(tǒng)受累組和無血液系統(tǒng)受累組,分析血液系統(tǒng)受累與SLE臨床指標(biāo)、實驗室指標(biāo)、疾病活動度等相關(guān)性。數(shù)據(jù)采用SPSS20.0進(jìn)行統(tǒng)計分析。結(jié)果:(1)334例SLE患者納入研究范圍,其中女性患者311例,男性患者23例。SLE患者中,213例(63.8%)患者合并血液系統(tǒng)受累,其中貧血占49.1%,白細(xì)胞減少占32.0%,血小板減少占18.6%;單系血細(xì)胞減少占35.9%,兩系及兩系以上受損占27.8%。(2)與無血液系統(tǒng)受累組比較,血液系統(tǒng)受累組皮疹、黏膜潰瘍及漿膜炎的比例明顯增多,差異具有顯著性(P0.05)。(3)SLE患者中,血液系統(tǒng)受累組紅細(xì)胞沉降率升高、補體C3降低、抗雙鏈DNA抗體陽性、抗心磷脂抗體陽性率明顯高于無血液系統(tǒng)受累組,差異具有統(tǒng)計學(xué)意義(P0.05)。(4)血液系統(tǒng)受累組疾病輕、中和重度活動例數(shù)與無血液系統(tǒng)受累組比較明顯增多,差異均有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:血液系統(tǒng)是SLE患者最常受累的系統(tǒng)之一,以貧血最為常見;合并血液系統(tǒng)受累SLE患者免疫學(xué)指標(biāo)明顯異常,病情活動更明顯。
[Abstract]:Objective: to analyze the characteristics of blood system involvement in patients with systemic lupus erythematosus (lupus) and to explore its clinical significance. Methods: according to the requirements of National Rheumatological data Center, the clinical data of 334 patients with SLE were collected and analyzed. The patients were divided into two groups: the group with blood system involvement and the group without blood system involvement. The clinical indexes and laboratory indexes of blood system involvement and SLE were analyzed. Data were analyzed by SPSS20.0. Results 1334 patients with SLE were included in the study, including 311 female patients and 213 cases of male patients (63.8%). Anemia accounted for 49.1%, leukopenia accounted for 32.0%, thrombocytopenia accounted for 18.66.Monocytocytopenia accounted for 35.9%, and damage of two or more lines accounted for 27.80.2.Compared with the group without involvement of the blood system, the hematological system involved group had rash. The percentage of mucosal ulcers and serositis increased significantly. The erythrocyte sedimentation rate increased, complement C3 decreased and anti-double-stranded DNA antibody was positive in the blood system involvement group. The positive rate of anticardiolipin antibody was significantly higher than that of the group without involvement of blood system, the difference was statistically significant (P 0.05. 05. 4) the number of moderate and severe activity in the group of blood system involvement was significantly higher than that in the group without involvement of blood system. Conclusion: the blood system is one of the most frequently involved systems in patients with SLE, anemia is the most common, and the immunological indexes in patients with SLE complicated with hematological system involvement are obviously abnormal, and the disease activity is more obvious.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R593.241

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