本文選題：CXCL16　切入點(diǎn)：糖尿病足病　出處：《華北理工大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的CXCL16是近年新發(fā)現(xiàn)的趨化因子,它與糖尿病足病的關(guān)系尚未見(jiàn)報(bào)道。本試驗(yàn)通過(guò)檢測(cè)糖尿病足病患者血清CXCL16濃度變化,旨在探討血清分泌型CXCL16與糖尿病足病的相關(guān)性。方法1以2013年1月至2014年12月在華北理工大學(xué)附屬開(kāi)灤總醫(yī)院內(nèi)分泌科住院的164例糖尿病患者作為受試對(duì)象,其中以90例糖尿病足病患者作為病例組,以74例單純糖尿病患者作為對(duì)照組。采用酶聯(lián)免疫吸附雙抗體夾心法測(cè)定病例組和對(duì)照組血清CXCL16的濃度。記錄受試對(duì)象的一般臨床資料并比較兩組間一般臨床資料及血清CXCL16水平的差異。以高CXCL16水平作為暴露因素,利用四格表及OR值分析高CXCL16水平與糖尿病足病有無(wú)關(guān)聯(lián)以及關(guān)聯(lián)強(qiáng)度的大小。采用多因素Logistic逐步回歸分析法探討糖尿病足病的影響因素。2將病例組患者按是否存在足部缺血分為缺血組和非缺血組,采用相同的方法分析CXCL16與缺血性糖尿病足病的關(guān)系。結(jié)果1病例組血清CXCL16水平明顯高于對(duì)照組(P0.01)。糖尿病患者血清CXCL16濃度在1.72μg/L以上時(shí),患糖尿病足病的危險(xiǎn)性是CXCL16在1.72μg/L以下患者的4.39倍。以是否患糖尿病足病為因變量,以病例組和對(duì)照組兩組間差異具有顯著性的指標(biāo)為自變量做Logistic回歸分析。結(jié)果顯示,隨著血清CXCL16和纖維蛋白原濃度的逐漸增高,糖尿病患者患糖尿病足病的危險(xiǎn)性逐漸增大,CXCL16和纖維蛋白原是糖尿病足病的危險(xiǎn)因素。2缺血組血清CXCL16濃度明顯高于非缺血組(P0.01)。糖尿病足病患者血清CXCL16濃度在2.04μg/L以上時(shí),患缺血性糖尿病足病的危險(xiǎn)性是CXCL16在2.04μg/L以下患者的6.09倍。以糖尿病足病是否存在足部缺血為因變量,以缺血組和非缺血組兩組間具有顯著差異的指標(biāo)為自變量做Logistic回歸分析。結(jié)果顯示,隨著CXCL16和纖維蛋白原濃度的逐漸增高,血紅蛋白和總膽紅素濃度的逐漸降低,糖尿病足病患者發(fā)生足部缺血的危險(xiǎn)性逐漸增大,CXCL16和纖維蛋白原是缺血性糖尿病足病的危險(xiǎn)因素,總膽紅素和血紅蛋白是它的保護(hù)因素。結(jié)論1血清分泌型CXCL16與糖尿病足病呈正相關(guān),在一定程度上促進(jìn)了糖尿病足病的發(fā)生和發(fā)展。2血清分泌型CXCL16與糖尿病足病足部缺血程度呈正相關(guān)。
[Abstract]:Objective CXCL16 is a newly discovered chemokine in recent years. The relationship between CXCL16 and diabetic foot disease has not been reported. Objective to investigate the relationship between serum secretory CXCL16 and diabetic foot disease. Methods 1 A total of 164 diabetic patients hospitalized in the Department of Endocrinology of Kailuan General Hospital affiliated to North China University of Technology from January 2013 to December 2014 were selected as subjects. Among them, 90 cases of diabetic foot disease were used as the case group. 74 patients with simple diabetes mellitus were used as control group. The serum CXCL16 concentration was measured by enzyme-linked immunosorbent assay (Elisa). The general clinical data of the subjects were recorded and the general clinical information was compared between the two groups. The difference of serum CXCL16 levels. High CXCL16 levels were used as exposure factors. The relationship between high CXCL16 level and diabetic foot disease and the magnitude of correlation strength were analyzed by using four case tables and OR value. The multivariate Logistic stepwise regression analysis was used to study the influencing factors of diabetic foot disease. 2. In the foot ischemia is divided into ischemic group and non-ischemic group, The relationship between CXCL16 and ischemic diabetic foot disease was analyzed by the same method. Results the level of serum CXCL16 in the first case group was significantly higher than that in the control group (P 0.01). When the serum CXCL16 concentration of diabetic patients was more than 1.72 渭 g / L. The risk of diabetic foot disease was 4.39 times higher than that of patients with CXCL16 below 1.72 渭 g / L. the Logistic regression analysis was performed with the dependent variable of diabetic foot disease and the index with significant difference between the two groups. The results showed that the risk of diabetic foot disease was less than 1.72 渭 g / L, and the risk of diabetic foot disease was 4.39 times higher than that of patients with CXCL16 below 1.72 渭 g / L. With the increase of serum CXCL16 and fibrinogen concentration, CXCL16 and fibrinogen were the risk factors of diabetic foot disease. 2 the serum CXCL16 concentration in ischemic group was significantly higher than that in non-ischemic group (P 0.01). When the serum CXCL16 concentration of diabetic foot disease was above 2.04 渭 g / L. The risk of ischemic diabetic foot disease was 6.09 times higher than that of patients with CXCL16 below 2.04 渭 g / L. The results of Logistic regression analysis showed that the concentration of hemoglobin and total bilirubin decreased with the increase of CXCL16 and fibrinogen concentration. CXCL16 and fibrinogen are the risk factors of diabetic foot disease. Total bilirubin and hemoglobin were the protective factors. Conclusion 1 Serum secretory CXCL16 is positively correlated with diabetic foot disease. To some extent, it promoted the occurrence and development of diabetic foot disease. 2 Serum secretory CXCL16 was positively correlated with the degree of diabetic foot ischemia.
【學(xué)位授予單位】：華北理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R587.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 Antonino Tuttolomondo;Carlo Maida;Antonio Pinto;;Diabetic foot syndrome:Immune-inflammatory features as possible cardiovascular markers in diabetes[J];World Journal of Orthopedics;2015年01期

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本文編號(hào)：1622956