本文選題：慢性苯中毒　切入點(diǎn)：血常規(guī)　出處：《環(huán)境與職業(yè)醫(yī)學(xué)》2017年05期 　論文類型：期刊論文

【摘要】：[目的]研究慢性苯中毒患者脫離苯接觸2~48年后,血常規(guī)指標(biāo)與外周血淋巴細(xì)胞微核率變化特征,及二者關(guān)系。[方法]以上海市某醫(yī)院診斷的36例慢性苯中毒患者(確診后均脫離苯接觸)為病例組,按照性別、年齡匹配在社區(qū)選擇36名健康者作為對(duì)照組。對(duì)72名研究對(duì)象進(jìn)行血常規(guī)檢測(cè),并采用胞質(zhì)分裂阻滯微核實(shí)驗(yàn)檢測(cè)微核率。分別用配對(duì)t檢驗(yàn)、Poisson回歸比較病例組和對(duì)照組的血常規(guī)結(jié)果和微核率,用趨勢(shì)性檢驗(yàn)分析病例組血常規(guī)結(jié)果與微核率之間的關(guān)系,用卡方檢驗(yàn)分析微核異常率,用logistic回歸模型分析微核率異常的影響因素。[結(jié)果]與對(duì)照組相比,病例組的白細(xì)胞計(jì)數(shù)下降了1.95×10~9/L、中性粒細(xì)胞下降了0.85×10~9/L、淋巴細(xì)胞下降了0.7×10~9/L、紅細(xì)胞計(jì)數(shù)下降了0.39×10~(12)/L、血紅蛋白下降了9.21 g/L及血小板下降了50.17×10~(12)/L,差異均具有統(tǒng)計(jì)學(xué)意(P0.01);病例組白細(xì)胞異常率、中性粒細(xì)胞異常率、血紅蛋白異常率與對(duì)照組差異具有統(tǒng)計(jì)學(xué)意義(χ~2=20.67,P0.001;χ~2=12.77,P0.001;χ~2=11.61,P=0.001);病例組和對(duì)照組的外周血淋巴細(xì)胞微核率分別為(7.22±2.87)‰和(4.14±1.66)‰,病例組微核率比對(duì)照組升高74%(FR=1.74,P0.001)。白細(xì)胞、中性粒細(xì)胞均與微核率呈負(fù)相關(guān),Spearman相關(guān)系數(shù)分別為-0.416、-0.495(P0.05,P0.01)。病例組18例當(dāng)前白細(xì)胞正常者(≥4.0×10~9/L且≤10.0×10~9/L),其微核率仍高于配對(duì)對(duì)照組(FR=1.40,P0.05)。病例組按脫離苯接觸年數(shù)分組,與對(duì)照組相比,隨著脫離年數(shù)的增加,三組微核率均升高(FR=1.46,P=0.025;FR=1.92,P0.001;FR=1.79,P0.001)。三組微核率異常的風(fēng)險(xiǎn)有升高趨勢(shì)(OR=4.05,P=0.153;OR=27.33,P=0.001;OR=355.26,P=0.001)。[結(jié)論]慢性苯中毒患者脫離苯接觸后仍會(huì)持續(xù)存在血液毒性與遺傳毒性,微核率比白細(xì)胞更加敏感。
[Abstract]:[objective] to study the changes of blood routine indexes and micronucleus rate of peripheral blood lymphocytes in patients with chronic benzene poisoning after 2 ~ 48 years of exposure to benzene. [methods] 36 cases of chronic benzene poisoning diagnosed by a hospital in Shanghai were selected as the case group. Age matching selected 36 healthy people as the control group in the community. Blood routine examination was performed on 72 subjects. The micronucleus rate was detected by cytokinesis block micronucleus test. The blood routine results and micronucleus rates were compared by paired t test Poisson regression, and the relationship between blood routine results and micronucleus rate was analyzed by trend test. The abnormal rate of micronucleus was analyzed by chi-square test and the influencing factors of abnormal rate of micronucleus were analyzed by logistic regression model. [results] compared with the control group, In the case group, the leukocyte count decreased by 1.95 脳 10 ~ (9) / L, the neutrophils decreased by 0.85 脳 10 ~ (9) / L, the lymphocytes decreased by 0.7 脳 10 ~ (9) / L, the erythrocyte count decreased by 0.39 脳 10 ~ (10) / L, the hemoglobin decreased by 9.21 g / L, and the platelet decreased by 50.17 脳 10 ~ (12) / L, the difference was statistically significant. The abnormal rate of neutrophil and hemoglobin were significantly different from those of the control group (蠂 ~ 2 ~ 2n ~ (20. 67) P _ (0.001); 蠂 ~ (2 +) ~ (2)) ~ (12.77) P _ (0.001); 蠂 ~ (2 +) ~ (2) C ~ (11.61) P ~ (0.001); the micronucleus rate of peripheral blood lymphocytes in the case group and the control group were 7.22 鹵2.87 鈥，

本文編號(hào)：1619676