本文選題：中老年　切入點(diǎn)：高尿酸血癥　出處：《寧夏醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的1.了解寧夏城市地區(qū)回、漢族中老年人高尿酸血癥患病率情況并對(duì)比;2.分析中老年人群雌二醇、睪酮與血尿酸水平的相關(guān)性;3.分析影響中老年人群血尿酸水平的相關(guān)因素。方法采用整群抽樣的流行病學(xué)調(diào)查方法,調(diào)查2011年8月-2012年12月銀川市、吳忠市五個(gè)不同社區(qū)人群1295人(回漢比例為1:1.91),對(duì)調(diào)查人群進(jìn)行問(wèn)卷調(diào)查、體格檢查,并檢測(cè)尿酸(UA)、睪酮(T)、雌二醇(E2)、空腹胰島素(INS)、性激素結(jié)合球蛋白(SHBG)、總膽固醇(TC)、甘油三酯(TG)、空腹血糖(FBG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)等指標(biāo),采用SPSS17.0軟件進(jìn)行數(shù)據(jù)分析。結(jié)果1.男性睪酮65歲以后隨年齡有降低趨勢(shì)(F=7.146,P=0.000),女性雌二醇水平55歲以后呈降低趨勢(shì)(F=5.315,P=0.001)。2.回族高尿酸血癥患病率為7.87%;漢族高尿酸血癥患病率為12.47%,漢族中老年人高尿酸血癥患病率高于回族(2x=6.385,P=0.011)。3.男性高尿酸血癥患病率17.82%,女性高尿酸血癥患病率4.39%,男性患病率高于女性(2x=59.839,P=0.000)。各年齡組男性均高于女性(P0.05)。4.回、漢族人群高血壓組的高尿酸血癥患病率均高于正常血壓組(P0.05)。5.在線性回歸分析中,血尿酸隨睪酮(B=0.037,P=0.000)、空腹血糖(B=2.475,P=0.011)、甘油三酯(B=10.066,P=0.000)、收縮壓(B=0.379,P=0.001)的升高而升高,隨HDL-C(B=-8.706,P=0.000)的升高而降低。結(jié)論1.高尿酸血癥患病率在回漢民族間、男女性別間存在差異。2.高血壓、空腹血糖升高、血脂代謝紊亂與血尿酸水平相關(guān)。3.高密度脂蛋白與血尿酸水平呈負(fù)相關(guān)。4.機(jī)體睪酮水平與血尿酸呈正相關(guān)。該研究提示:高尿酸血癥的患病率與性別、血壓和甘油三酯水平有關(guān),預(yù)防高尿酸血癥應(yīng)從控制血壓、降低甘油三酯水平著手。
[Abstract]:Objective 1. To understand the prevalence of hyperuricemia in middle and middle aged people in urban areas of Ningxia and to compare the prevalence of hyperuricemia. The correlation between testosterone and serum uric acid levels. 3. Analysis of the related factors affecting the serum uric acid level in the middle-aged and elderly population. Methods the epidemiological survey method of cluster sampling was used to investigate Yinchuan City from August 2011 to December 2012. In Wuzhong City, 1295 people from five different communities (the ratio of returning to Han is 1: 1.91) were investigated by questionnaire and physical examination. The indexes of UAA, testosterone, estradiol, estradiol, fasting insulin, sex hormone binding globulin, total cholesterol, triglyceride, fasting blood glucose, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were detected. SPSS17.0 software was used to analyze the data. 1. Male testosterone decreased with age after 65 years of age, and female estradiol level decreased after 55 years. The prevalence of hyperuricemia was 7.87% in Hui nationality and 7.87% in Han nationality. The prevalence rate of hyperuricemia was 12.47. The prevalence rate of hyperuricemia in the Han nationality was higher than that in the Hui nationality. The prevalence rate of hyperuricemia was 17.82% in males and 4.39 in females. The prevalence rate of hyperuricemia in males was higher than that in females (2x59.839 P0.000). The prevalence of hyperuricemia in males was higher than that in females. The prevalence rate of hyperuricemia in the hypertension group of Han nationality was higher than that in the normal blood pressure group (P 0.05). In linear regression analysis, the serum uric acid was increased with the increase of testosterone (0.037), fasting blood glucose (B) 2.475p (0.011), triglyceride (10.066P0.000), systolic blood pressure (B0.379p 0.001). Conclusion 1. The prevalence rate of hyperuricemia is different between male and female in the Hui Han nationality. 2. Hypertension, fasting blood glucose increase, the incidence of hyperuricemia is decreased with the increase of HDL-Con (8. 706) (P < 0. 000). 1. The prevalence of hyperuricemia is different between male and female. High density lipoprotein (HDL) has a negative correlation with serum uric acid level. 4. There is a positive correlation between serum testosterone level and serum uric acid level. This study suggests: prevalence and sex of hyperuricemia. Blood pressure is related to triglyceride level. To prevent hyperuricemia, we should control blood pressure and reduce triglyceride level.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R589.7

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本文編號(hào)：1602963