發(fā)布時間：2018-03-12 11:51

  本文選題：丹紅注射液　切入點：糖尿病腎病　出處：《中國老年學雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的觀察丹紅注射液輔助治療對糖尿病腎病(DN)患者血小板活化依賴性顆粒表面膜蛋白(CD62p)、血小板激活復合物(PAC)-1表達的影響。方法 95例DN患者隨機分為對照組與治療組,治療組在常規(guī)療法的基礎(chǔ)上靜注丹紅注射液(20 ml/次),采用流式細胞術(shù)檢測治療前后CD62p、PAC-1的表達。結(jié)果治療前兩組DN患者的血小板CD62p、PAC-1無顯著差異;對照組常規(guī)治療后血小板CD62p、PAC-1無明顯變化;治療組聯(lián)合丹紅注射液治療顯著降低了血小板CD62p、PAC-1陽性表達率;且治療組治療后的血小板CD62p、PAC-1顯著低于對照組治療后。結(jié)論丹紅注射液輔助治療可明顯抑制DN患者血小板活化,這對于降低血栓形成是有利的。
[Abstract]:Objective to observe the effect of Danhong injection on the expression of platelet activation dependent granule membrane protein (CD62pN) and platelet-activated complex (PAC- 1) in patients with diabetic nephropathy (DN). Methods 95 patients with DN were randomly divided into two groups: control group and treatment group. In the treatment group, the expression of CD62ptPAC-1 was detected by flow cytometry on the basis of routine therapy. Results there was no significant difference in platelet CD62pPAC-1 between the two groups before and after treatment. In the control group, there was no significant change in platelet CD62pnPAC-1 after routine treatment, and the positive expression rate of platelet CD62pnPAC-1 was significantly decreased in the treatment group combined with Danhong injection. The platelet CD62pnPAC-1 after treatment in the treatment group was significantly lower than that in the control group. Conclusion the adjuvant treatment with Danhong injection can significantly inhibit platelet activation in patients with DN, which is beneficial to reduce thrombus formation.
【作者單位】： 河北北方學院附屬第一醫(yī)院;天津醫(yī)科大學代謝病醫(yī)院;秦皇島衛(wèi)生學院;
【分類號】：R587.2;R692.9

【參考文獻】

相關(guān)期刊論文 前4條

1 劉金虹;;丹紅注射液的臨床應用進展[J];中國藥房;2014年23期

2 趙令君;劉玉峰;吳淋淋;劉樹軍;;糖尿病腎病最新國際病理診斷標準的臨床應用研究[J];中國實驗診斷學;2014年05期

3 Maria L Gonzalez Suarez;David B Thomas;Laura Barisoni;Alessia Fornoni;;Diabetic nephropathy:Is it time yet for routine kidney biopsy?[J];World Journal of Diabetes;2013年06期

4 陸菊明,潘長玉;糖尿病腎病的流行病學和診斷標準[J];中華老年多器官疾病雜志;2002年03期

【共引文獻】

相關(guān)期刊論文 前10條

1 吳淋淋;楊帆;劉樹軍;羅萍;董曉明;;老年腎活檢患者臨床及病理資料分析[J];中國實驗診斷學;2017年02期

2 李明霞;于佩;王俊芳;趙軼峰;任衛(wèi)東;張斌;;丹紅注射液輔助治療對糖尿病腎病患者血小板CD62p、血小板激活復合物-1表達的影響[J];中國老年學雜志;2017年04期

3 陳燦鋒;王家健;侯曉濤;李連青;;2型糖尿病腎病病理分型特點與尿蛋白的關(guān)系[J];標記免疫分析與臨床;2017年02期

4 Isabelle Hota Tadida Meli;Aurel T Tankeu;Mesmin Y Dehayem;David Chelo;Jean Jacques N Noubiap;Eugene Sobngwi;;Exercise-induced albuminuria vs circadian variations in blood pressure in type 1 diabetes[J];World Journal of Diabetes;2017年02期

5 張莉;王瑜;杜桂英;程玉花;呂金雷;陳欽開;;Toll樣受體4在糖尿病腎病患者腎組織中的表達及厄貝沙坦的干預作用[J];華中科技大學學報(醫(yī)學版);2017年01期

6 李明霞;趙軼峰;于s，

本文編號：1601431