本文選題：痛風(fēng)　切入點(diǎn)：六味痛風(fēng)飲　出處：《青島大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的:觀察六味痛風(fēng)飲對(duì)痛風(fēng)性關(guān)節(jié)炎間歇期患者的臨床療效及相關(guān)的不良反應(yīng)的影響,為其在臨床上廣泛應(yīng)用提供依據(jù)。進(jìn)一步論證肝經(jīng)濁毒與痛風(fēng)密不可分。方法:將60例符合診斷和納入標(biāo)準(zhǔn)的痛風(fēng)性關(guān)節(jié)炎患者隨機(jī)分為治療組和對(duì)照組,每組各30例。治療組給予六味痛風(fēng)飲治療,溫水沖服,15克/次,早晚各一次;對(duì)照組給予苯溴馬隆片治療,50毫克/次,1次/天,早餐后口服。兩組均連續(xù)治療,療程4周,檢測(cè)治療前后兩組患者的血清尿酸,血脂(甘油三酯、總膽固醇),腎功能(尿素氮、血肌酐),谷丙轉(zhuǎn)氨酶,血糖以及血常規(guī)等。結(jié)果:兩組均能降低血清尿酸,治療組總有效率為86.67%,對(duì)照組總有效率為93.33%。治療組患者尿酸下降程度低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療組各實(shí)驗(yàn)指標(biāo)(TC、TG、Glu)較治療前均有所下降(P0.05),而對(duì)照組在治療前后無(wú)統(tǒng)計(jì)學(xué)意義;兩組對(duì)患者血常規(guī)、ALT、腎功(SCr、BUN)均沒(méi)有影響,治療組降低血肌酐作用更強(qiáng)。結(jié)論:1.六味痛風(fēng)飲與苯溴馬隆均可以有效降低痛風(fēng)患者的血清尿酸,但苯溴馬隆優(yōu)于六味痛風(fēng)飲。2.六味痛風(fēng)飲在有效降低痛風(fēng)患者血尿酸水平的同時(shí),還可以降低血脂水平,有益于改善患者肝臟功能,對(duì)痛風(fēng)患者伴有如糖尿病、高血壓等代謝性疾病以及心腦血管病的患者的臨床應(yīng)用更有益。苯溴馬隆沒(méi)有對(duì)血脂、肝功的有利影響。3.六味痛風(fēng)飲降低血清尿酸的機(jī)制可能是增加尿酸從腸道的排泄量,這樣在降低血清尿酸的同時(shí)不增加腎臟排泄尿酸的負(fù)擔(dān)。4.六味痛風(fēng)飲不良反應(yīng)相對(duì)較少,安全性高,且經(jīng)濟(jì)簡(jiǎn)便,適合長(zhǎng)期應(yīng)用,值得進(jìn)行臨床推廣。5.肝經(jīng)濁毒是導(dǎo)致痛風(fēng)發(fā)病的病理因素。
[Abstract]:Objective: To observe the effect of six kinds of Tongfengyin clinical efficacy in patients with gouty arthritis episodes and related adverse reactions, is widely used in clinic. Provide the basis for further proof of liver toxicity and gout are inseparable. Methods: 60 patients with the diagnosis and inclusion criteria of patients with gouty arthritis were randomly divided for the treatment group and control group, 30 cases in each group. The treatment group was given six kinds of decoction for the treatment of gout, warm water, 15 grams / times, sooner or later each time; the control group was given the treatment of Benzbromarone Tablets, 50 mg / time, 1 times / day, orally after breakfast. The two groups were treated continuously for 4 weeks. Serum uric acid, two groups of patients were detected before and after treatment, blood lipids (triglycerides, total cholesterol), renal function (blood urea nitrogen, creatinine), alanine aminotransferase, blood glucose and blood routine. Results: the two groups can reduce serum uric acid, the total efficiency of treatment group was 86.67%, the total efficiency of the control group Is lower than the control group 93.33%. treatment group with uric acid, the difference was statistically significant (P0.05); the experimental group index (TC, TG, Glu treatment) than before treatment decreased (P0.05), while the control group were no statistical significance before and after treatment; two groups of patients with blood routine, renal function (ALT, SCr BUN), had no effect, the treatment group decreased serum creatinine stronger. Conclusion: 1. six kinds of Tongfengyin and benzene bromine Malone were effective in reducing serum uric acid in patients with gout, but the taste is better than six benzene bromine Malone Tongfengyin.2. six Wei Tongfeng drink can reduce suffering from gout and blood uric acid level, but also can the serum lipid level, beneficial to improve liver function in patients with gout patients with such as diabetes, hypertension and other more beneficial metabolic diseases and clinical application of cardiovascular and cerebrovascular disease patients. Benzene bromine Malone no beneficial effects on blood lipid, liver function,.3. six kinds of Tongfengyin reduce The mechanism of serum uric acid may increase uric acid excretion from the gut, so in the reduction of serum uric acid and renal excretion of uric acid does not increase the burden of.4. six kinds of Tongfengyin relatively less adverse reactions, high safety, simple and economic, suitable for long-term use, is worthy of clinical promotion of.5. liver toxicity is the result of pathological factors of gout the onset of disease.

【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R589.7

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 谷祖華;苗志敏;李長(zhǎng)貴;;Caspase-1抑制劑對(duì)大鼠急性痛風(fēng)性關(guān)節(jié)炎的作用[J];青島大學(xué)醫(yī)學(xué)院學(xué)報(bào);2009年05期

2 孫培;;蘆薈的藥理作用研究進(jìn)展[J];湖北中醫(yī)雜志;2012年04期

3 王剛;陳曉;丁培東;;利濕通絡(luò)方治療急性痛風(fēng)性關(guān)節(jié)炎及高尿酸血癥46例[J];中國(guó)實(shí)驗(yàn)方劑學(xué)雜志;2014年01期

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本文編號(hào)：1595879