本文選題：鼠神經(jīng)生長因子　切入點：電燒傷　出處：《中國藥房》2016年11期 　論文類型：期刊論文

【摘要】：目的:探討鼠神經(jīng)生長因子修復(fù)老年電燒傷患者神經(jīng)損傷的臨床療效。方法:78例老年電燒傷患者按照隨機數(shù)字表法分為試驗組(40例)和對照組(38例)。兩組患者均給予抗感染、改善微循環(huán)等常規(guī)治療,在此基礎(chǔ)上對照組患者肌內(nèi)注射維生素B12,每次500μg,qd;試驗組患者肌內(nèi)注射鼠神經(jīng)生長因子,每次18μg,qd,兩組均4周為1個療程,共治療2個療程。比較兩組患者治療前后神經(jīng)功能評分、神經(jīng)傳導(dǎo)速度的差異;觀察兩組患者的臨床療效及不良反應(yīng)發(fā)生情況。結(jié)果:治療前,兩組患者的針刺覺評分、輕觸覺評分、運動評分、感覺神經(jīng)傳導(dǎo)速度與運動神經(jīng)傳導(dǎo)速度比較,差異均無統(tǒng)計學(xué)意義(P0.05)。治療后,試驗組患者的針刺覺、輕觸覺與運動評分均較治療前及對照組顯著提高,感覺神經(jīng)傳導(dǎo)速度與運動神經(jīng)傳導(dǎo)速度均較治療前及對照組顯著加快,差異具有統(tǒng)計學(xué)意義(P0.05)。試驗組患者的總有效率為92.5%,顯著高于對照組(63.2%),差異具有統(tǒng)計學(xué)意義(P0.05)。兩組患者均未見明顯不良反應(yīng)發(fā)生。結(jié)論:肌內(nèi)注射鼠神經(jīng)生長因子修復(fù)老年電燒傷患者的神經(jīng)損傷,不僅能夠提高其神經(jīng)功能評分,加快其神經(jīng)傳導(dǎo)速度,還能夠提高整體臨床療效。
[Abstract]:Objective: to investigate the clinical efficacy of nerve growth factor (NGF) in repairing nerve injury in elderly patients with electrical burn. Methods: 78 cases of senile electric burn patients were divided into two groups according to random number table: the experimental group (n = 40) and the control group (n = 38). On the basis of improving microcirculation and other routine treatments, the patients in the control group received intramuscular injection of vitamin B12 at 500 渭 g / kg QD, and the patients in the test group received intramuscular injection of nerve growth factor (NGF) at a dose of 18 渭 g QD for 4 weeks as a course of treatment. To compare the difference of nerve function score and nerve conduction velocity between the two groups before and after treatment, to observe the clinical curative effect and adverse reaction of the two groups. Results: before the treatment, the acupuncture sensation score of the two groups was compared. The scores of light tactile sensation, motor score, sensory nerve conduction velocity and motor nerve conduction velocity had no significant difference (P 0.05). After treatment, the acupuncture sensation, light tactile sensation and motor score of the patients in the experimental group were significantly higher than those before treatment and in the control group. Sensory nerve conduction velocity and motor nerve conduction velocity were significantly faster than those before treatment and control group. The total effective rate of the patients in the test group was 92.5, which was significantly higher than that in the control group (63.2%), and the difference was statistically significant (P 0.05). There was no significant adverse reaction in the two groups. Conclusion: nerve growth factor in intramuscular injection rats. To repair nerve damage in elderly patients with electrical burns, It can not only improve the neurological function score, accelerate the nerve conduction velocity, but also improve the overall clinical efficacy.
【作者單位】： 河北醫(yī)科大學(xué)第一醫(yī)院燒傷整形科;
【基金】：河北省醫(yī)學(xué)科學(xué)研究重點課題(No.20130273)
【分類號】：R647

【相似文獻】

相關(guān)期刊論文 前10條

1 林源,王潤秀,黎信森;92例電燒傷的臨床分析[J];廣西醫(yī)學(xué);2000年02期

2 林源;92例電燒傷致傷方式分析[J];右江民族醫(yī)學(xué)院學(xué)報;2000年01期

3 孫慶玉,李惠斌,陳芳;62例兒童電燒傷分析[J];華夏醫(yī)學(xué);2001年06期

4 陳越秀,徐穎,胡曉娟,郭振榮,柴家科,李力根;高分辨率二維超聲在深度電燒傷的應(yīng)用價值[J];中國超聲醫(yī)學(xué)雜志;2002年01期

5 黃弘,黃賢慧,劉旭盛;電燒傷臨床治療33例[J];中華燒傷雜志;2003年03期

6 李凡,陳開翠;215例電燒傷患者臨床治療體會與分析[J];職業(yè)衛(wèi)生與病傷;2004年04期

7 劉穎;衛(wèi)廣輝;;電燒傷臨床治療體會[J];現(xiàn)代醫(yī)藥衛(wèi)生;2006年11期

8 張獻懷;;電燒傷毀損診治研究創(chuàng)新多[J];中國社區(qū)醫(yī)師(綜合版);2007年05期

9 盧青軍;;電燒傷研究進展[J];實用醫(yī)學(xué)雜志;2007年12期

10 劉穎;衛(wèi)廣輝;;電燒傷臨床治療體會[J];中國實用醫(yī)藥;2007年33期

相關(guān)會議論文 前10條

1 朱維平;吳亞莉;徐雪璋;;特殊部位嚴重電燒傷的治療體會摘要[A];中華醫(yī)學(xué)會第五次全國燒傷外科學(xué)術(shù)會議論文匯編[C];1997年

2 周玲;張科驗;孫堂卿;張磊;趙秋芳;;電燒傷207例臨床分析[A];中華醫(yī)學(xué)會第五次全國燒傷外科學(xué)術(shù)會議論文匯編[C];1997年

3 陳浩杰;李梅;朱維平;高曉燕;王彬彬;陳國華;;頭部深部電燒傷的修復(fù)[A];第六屆全國燒傷救治專題研討會論文匯編[C];2009年

4 蘇建東;王志學(xué);王s，

本文編號：1595347