本文選題：脂肪酸　切入點：甘油三酯　出處：《浙江大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：青少年時期的血漿甘油三酯水平升高、血脂代謝異常被廣泛認(rèn)為是成年后的肥胖、代謝綜合癥和心血管疾病的早期癥候。研究表明空腹血脂水平與膳食脂肪的攝入密切相關(guān)。目前,針對中國青少年兒童膳食脂肪攝入情況與空腹血脂水平的研究相對較少,而且由于研究對象的遺傳基礎(chǔ)存在差異以及其受后天環(huán)境的影響不同,以往相關(guān)的研究結(jié)果存在不一致。本研究納入了浙江嘉興地區(qū)的311對7-15周歲的健康青少年雙生子,測定研究對象的全血脂肪酸組成,將其作為膳食脂肪攝入的生物標(biāo)記物,探討了研究中國青少年膳食脂肪攝入情況與空腹血脂水平的關(guān)系。同時利用雙生子研究的特點,即雙生子分為遺傳基礎(chǔ)完全相同的單卵雙生子和在遺傳上平均有50%相同的異卵雙生子,成長在同一個家庭的一對雙生子,其受環(huán)境因素的影響也相同,我們進一步探討了青少年兒童全血脂肪酸組成與空腹血脂水平的關(guān)系是否受共同的遺傳和環(huán)境因素的影響。結(jié)果顯示,在排除了年齡、腰圍升高比、卵型、體育鍛煉情況、性成熟度和每日總攝入能量等因素后,青少年雙生子全血多不飽和脂肪酸含量,尤其是二十二碳六烯酸(DHA)的含量與空腹血漿甘油三酯濃度呈顯著負(fù)相關(guān)。針對單卵雙生子的對內(nèi)關(guān)聯(lián)性(within-pair association)分析顯示上述關(guān)系依然成立,這表明青少年雙生子全血DHA含量與空腹甘油三酯濃度的關(guān)系不受共有的遺傳和環(huán)境因素的影響。在本研究中,未發(fā)現(xiàn)青少年全血脂肪酸組成與總膽固醇、高密度脂蛋白膽固醇以及低密度脂蛋白膽固醇之間存在顯著相關(guān)或關(guān)聯(lián)。結(jié)果同時也提示,增加膳食中多不飽和脂肪酸,特別是DHA的攝入,可能是防止青少年高甘油三酯血癥的一個保護因素。
[Abstract]:Elevated plasma triglyceride levels and dyslipidemia in adolescence are widely thought to be obesity in adulthood. Metabolic syndrome and early signs of cardiovascular disease. Studies have shown that fasting blood lipid levels are closely related to dietary fat intake. Because of the difference of genetic basis and the influence of acquired environment, the results of previous studies are inconsistent. This study included 311 twins of healthy adolescents aged 7-15 in Jiaxing, Zhejiang Province. The fatty acid composition of whole blood was measured and used as a biomarker of dietary fat intake. The relationship between dietary fat intake and fasting blood lipid level in Chinese adolescents was studied. At the same time, the characteristics of Gemini study were used to study the relationship between dietary fat intake and fasting blood lipid level. That is, the twins are divided into monozygote twins with identical genetic basis and heterozygote twins with an average of 50% identical in heredity, and a pair of twins growing up in the same family are equally affected by environmental factors. We further explored whether the relationship between fatty acid composition in whole blood and fasting blood lipid level in adolescents and children was affected by common genetic and environmental factors. After sex maturity and total daily energy intake, the whole blood polyunsaturated fatty acids content in twins of adolescents, In particular, the content of 22 carbohexaenoic acid was negatively correlated with fasting plasma triglyceride concentration. The results indicated that the relationship between serum DHA content and fasting triglyceride concentration was not affected by common genetic and environmental factors. In this study, no fatty acid composition and total cholesterol were found in the whole blood of adolescents. There was a significant correlation or association between high density lipoprotein cholesterol and low density lipoprotein cholesterol. The results also suggested an increase in the intake of polyunsaturated fatty acids, especially DHA, in the diet. It may be a protective factor against hypertriglyceridemia in adolescents.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R589.2

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