發(fā)布時(shí)間：2018-03-09 11:54

  本文選題：肺部感染　切入點(diǎn)：糖尿病腎病　出處：《中華醫(yī)院感染學(xué)雜志》2017年17期 　論文類型：期刊論文

【摘要】：目的分析肺部感染對(duì)糖尿病腎病維持性血液透析患者的影響,并檢測病原菌分布及構(gòu)成比。方法分析2015年1月-2016年12月在醫(yī)院接受維持性血液透析的糖尿病腎病患者的臨床資料,依據(jù)透析治療期間是否并發(fā)肺部感染分為感染組58例及未感染組64例,另納入50例同期行健康體檢者作為對(duì)照組;分析感染組患者呼吸道病原菌分布,對(duì)比各組血清學(xué)指標(biāo),包括:白介素-17(IL-17)、白介素-1β(IL-1β)、超氧化物歧化酶(SOD)及丙二醛(MDA);對(duì)比肺功能相關(guān)指標(biāo),包括:FEV1、FVC、FEV1/FVC及FEV1%。結(jié)果 58例感染組患者呼吸道分泌物中共分離出病原菌69株,其中革蘭陽性菌41株占59.42%;革蘭陰性菌24株占34.78%;真菌4株占5.80%;感染組患者外周血IL-17、IL-1β及MDA水平均顯著高于對(duì)照組及未感染組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);感染組患者外周血SOD水平顯著低于未感染組及對(duì)照組(P0.05);感染組患者的FVC、FEV1、FEV1%及FEV1/FVC水平均顯著低于未感染組患者及對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論肺部感染可降低接受維持性血液透析的糖尿病腎病患者的肺功能,加劇系統(tǒng)性氧化應(yīng)激及炎癥反應(yīng)。
[Abstract]:Objective to analyze the effect of pulmonary infection on maintenance hemodialysis patients with diabetic nephropathy. Methods the clinical data of diabetic nephropathy patients undergoing maintenance hemodialysis from January 2015 to December 2016 were analyzed. According to whether pulmonary infection was complicated during dialysis treatment, it was divided into infection group (n = 58) and uninfected group (n = 64), and 50 healthy persons were included as control group, the distribution of respiratory pathogenic bacteria in infected group was analyzed, and the serological indexes were compared. Results 69 strains of pathogenic bacteria were isolated from respiratory secretions of 58 infected patients, including IL-17, IL-17, SOD, SOD) and malondialdehyde (MDAA), and compared with lung function related indexes, including FEV1 / FVCFEV1 / FVC and FEV1 / FVC, respectively. Among them, 41 strains of Gram-positive bacteria accounted for 59.42%, 24 strains of Gram-negative bacteria accounted for 34.78% and 4 strains of fungi accounted for 5.80%. The levels of IL-17 IL-1 尾 and MDA in peripheral blood of infected patients were significantly higher than those of control group and non-infected group. The levels of SOD in peripheral blood of the infected group were significantly lower than those of the uninfected group and the control group, and the levels of FEV1% and FEV1/FVC in the infected group were significantly lower than those in the uninfected group and the control group. Conclusion Pulmonary infection can reduce the pulmonary function of diabetic nephropathy patients undergoing maintenance hemodialysis and aggravate systemic oxidative stress and inflammatory reaction.
【作者單位】： 攀枝花市中西結(jié)合醫(yī)院內(nèi)分泌科;攀枝花市中西結(jié)合醫(yī)院腎內(nèi)科;
【基金】：四川省衛(wèi)生廳基金資助項(xiàng)目(20160423)
【分類號(hào)】：R563.1;R587.2;R692.9

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本文編號(hào)：1588427