本文選題：地方性氟中毒　切入點(diǎn)：白內(nèi)障　出處：《中國(guó)地方病防治雜志》2017年02期 　論文類型：期刊論文

【摘要】：目的研究探討地方性氟中毒與老年性白內(nèi)障患者發(fā)病間的相關(guān)性,以期為老年性白內(nèi)障患者的防治提供參考。方法對(duì)本市2015年1月至2015年12月期間同一鄉(xiāng)鎮(zhèn)的地方性氟中毒病區(qū)和非病區(qū)人群進(jìn)行大樣本量的流行病學(xué)調(diào)查,觀察比較在這一年內(nèi)不同地區(qū)人群新患老年性白內(nèi)障患者的發(fā)病率,同時(shí)對(duì)地方性氟中毒病區(qū)和非病區(qū)老年性白內(nèi)障患者的晶體氟含量進(jìn)行檢測(cè)比較。緊接著在2016年1月至2016年12月對(duì)地方性氟中毒病區(qū)更換飲用水前后新增老年性白內(nèi)障患者的發(fā)病率進(jìn)行比較分析。結(jié)果 (1)對(duì)這一年中地方性氟中毒病區(qū)2871例患者進(jìn)行調(diào)查,結(jié)果發(fā)現(xiàn)新增老年性白內(nèi)障患者79例,發(fā)病率為2.75%,對(duì)3107例非地方性氟中毒病區(qū)人群進(jìn)行調(diào)查,結(jié)果發(fā)現(xiàn)新增患有老年性白內(nèi)障患者25例,患病率為0.81%,兩組人群間新增白內(nèi)障患者發(fā)病率差異顯著(P0.05),提示氟中毒患者更容易患上白內(nèi)障。(2)地方性氟中毒病區(qū)79例老年性白內(nèi)障患者經(jīng)檢查晶體氟含量為(1.28±0.23)mg/l,非病區(qū)25例老年性白內(nèi)障患者晶體氟含量為(0.31±0.06)mg/l,提示氟中毒老年性白內(nèi)障患者晶體氟含量顯著高于非氟中毒老年性白內(nèi)障患者(P0.05);(3)氟中毒地區(qū)更換低氟飲用水后,老年性白內(nèi)障患者的發(fā)病率顯著降低(P0.05),提示地方性氟中毒患者老年性白內(nèi)障的發(fā)病與氟含量的高低密切相關(guān)。結(jié)論地方性氟中毒與老年性白內(nèi)障患者間存在明顯的相關(guān)性,氟中毒人群中出現(xiàn)老年性白內(nèi)障的發(fā)病率較高,且晶體氟含量高于非病區(qū)老年行白內(nèi)障患者,降低病區(qū)飲用水中的氟含量可減少老年性白內(nèi)障患者的發(fā)病率,可為老年性白內(nèi)障的防治提供參考。
[Abstract]:Objective to study the relationship between endemic fluorosis and senile cataract. Methods from January 2015 to December 2015, the population of endemic fluorosis and non-endemic fluorosis in the same town were investigated by epidemiological survey. To observe and compare the incidence of new senile cataract patients in different areas during the year. At the same time, the content of fluoride in senile cataract patients in endemic fluorosis area was compared with that in non-endemic area. Then, from January 2016 to December 2016, new senile patients were added before and after the replacement of drinking water in endemic fluorosis area. The incidence of cataract was compared and analyzed. Results: a total of 2871 cases of endemic fluorosis were investigated in this year. The results showed that there were 79 new senile cataract patients and the incidence rate was 2.75.The results showed that there were 25 new senile cataract patients in 3107 non-endemic fluorosis areas. The prevalence rate was 0.81.The difference of incidence of new cataract between the two groups was significant (P 0.05), suggesting that fluorosis patients are more likely to suffer from cataract. 2) 79 cases of senile cataract patients in endemic fluorosis area were examined to have a fluoride content of 1.28 鹵0.23 mg / L, non-fluorosis. The content of fluoride in 25 senile cataract patients was 0.31 鹵0.06 mg / L, which suggested that the fluoride content in senile cataract patients with fluorosis was significantly higher than that in non-fluorosis senile cataract patients (P 0.05). The incidence of senile cataract decreased significantly, suggesting that the incidence of senile cataract was closely related to the level of fluoride in endemic fluorosis patients. Conclusion there is a significant correlation between endemic fluorosis and senile cataract. The incidence of senile cataract in fluorosis population was higher, and the fluoride content of lens was higher than that of senile cataract patients in non-endemic area. Reducing the fluoride content in drinking water of endemic area could reduce the incidence of senile cataract. It can provide reference for the prevention and treatment of senile cataract.
【作者單位】： 川北醫(yī)學(xué)院附屬醫(yī)院眼科;浙江溫醫(yī)雷賽醫(yī)用激光科技有限公司;
【基金】：2013年度省國(guó)際科技合作專項(xiàng)計(jì)劃(2013C14010)
【分類號(hào)】：R599.1;R776.1

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