本文關(guān)鍵詞： 氧化應(yīng)激 2型糖尿病 慢性牙周炎 超氧化物歧化酶 丙二醛　出處：《南昌大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:本實(shí)驗(yàn)通過檢測和比較慢性牙周炎(chronic periodontitis,CP)與2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清丙二醛(malondialdehyde,MDA)和超氧化物歧化酶(superoxide dismutase,SOD)水平,以期探討慢性牙周炎與2型糖尿病的相關(guān)性。方法:本實(shí)驗(yàn)采用病例對照研究,選取慢性牙周炎患者20例(牙周炎組),2型糖尿病患者23例(糖尿病組),慢性牙周炎合并2型糖尿病患者24例(牙周炎合并糖尿病組),健康對照者21例(健康組)。檢測并比較各組牙周袋深度(probing depth,PD),附著喪失(attachment level,AL)、探診出血(bleeding on probing,BOP)、糖化血紅蛋白(HbA1c)、空腹血糖(FPG)、甘油三酯(TG)、總膽固醇(TCH)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、丙二醛和超氧化物歧化酶水平。所得數(shù)據(jù)計(jì)量資料以均數(shù)±標(biāo)準(zhǔn)差表示,多組間比較采用單因素方差分析,若有差異,進(jìn)一步采用LSD檢驗(yàn);計(jì)數(shù)資料的比較使用卡方檢驗(yàn)。結(jié)果:1、各組牙周臨床指標(biāo):牙周炎組、牙周炎合并糖尿病組分別與糖尿病組、健康組相比,各牙周臨床指標(biāo)明顯偏高;而牙周炎組與牙周炎合并糖尿病組之間牙周臨床指標(biāo)無統(tǒng)計(jì)學(xué)差異。2、生化指標(biāo)的比較:(1)各組甘油三酯、總膽固醇、低密度脂蛋白水平無統(tǒng)計(jì)學(xué)差異。(2)牙周炎組糖化血紅蛋白、空腹血糖、高密度脂蛋白水平與健康組無統(tǒng)計(jì)學(xué)差異。(3)糖尿病組和牙周炎合并糖尿病組的糖化血紅蛋白、空腹血糖水平高于牙周炎組和健康組,有統(tǒng)計(jì)學(xué)差異;糖尿病組和牙周炎合并糖尿病組高密度脂蛋白低于健康組,有統(tǒng)計(jì)學(xué)差異;糖尿病組與牙周炎合并糖尿病組之間糖化血紅蛋白、空腹血糖、高密度脂蛋白水平無統(tǒng)計(jì)學(xué)差異。3、各組丙二醛(MDA)和超氧化物歧化酶(SOD)水平的比較:糖尿病組、牙周炎合并糖尿病組血清MDA和SOD水平明顯高于牙周炎組、健康組,差異有統(tǒng)計(jì)學(xué)意義,其中糖尿病組MDA和SOD水平最高,健康組MDA水平最低,牙周炎組SOD水平最低。4、丙二醛(MDA)、超氧化物歧化酶(SOD)與其他臨床指標(biāo)之間直線相關(guān)性分析:丙二醛與超氧化物歧化酶、糖化血紅蛋白、空腹血糖、甘油三酯和年齡呈正相關(guān)關(guān)系,與牙周袋深度和牙周附著喪失無相關(guān)關(guān)系。超氧化物歧化酶與丙二醛、糖化血紅蛋白、空腹血糖和年齡呈正相關(guān)關(guān)系,與高密度脂蛋白、牙周袋深度和牙周附著喪失呈負(fù)相關(guān)關(guān)系。結(jié)論:1、2型糖尿病患者和慢性牙周炎合并2型糖尿病患者血清MDA、SOD水平較慢性牙周炎患者高。2、在所有受試者中血清MDA水平與SOD、糖化血紅蛋白、空腹血糖、甘油三酯和年齡呈正相關(guān)關(guān)系。3、在所有受試者中血清SOD水平與糖化血紅蛋白、空腹血糖和年齡呈正相關(guān),與高密度脂蛋白、牙周袋深度、牙周附著喪失呈負(fù)相關(guān)關(guān)系。
[Abstract]:Objective: to detect and compare the serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with chronic periodontitis and type 2 diabetes mellitus (type 2 diabetes mellitusus T2DM). Methods: a case-control study was conducted to investigate the relationship between chronic periodontitis and type 2 diabetes mellitus. Twenty patients with chronic periodontitis (23 patients with type 2 diabetes in periodontitis group), 24 patients with chronic periodontitis with type 2 diabetes mellitus (periodontitis combined with diabetes mellitus) and 21 healthy controls (healthy group) were selected. Detection and comparison of periodontal pouch depth probing, attachment level ALP, bleeding on probing BOP, glycosylated hemoglobin (HbA1cN), fasting blood glucose (FBG), triglyceride (TGN), total cholesterol (TCHC), high density lipoprotein (HDL), low density lipoprotein (LDL), malondialdehyde (MDA) and superoxide (O). Level of dismutase. Measured data are expressed as mean 鹵standard deviation. Single factor analysis of variance (ANOVA) was used for multigroup comparison, LSD test was used for further analysis of variance, and chi-square test was used for the comparison of counting data. Results: the periodontal clinical indexes in each group: periodontitis group, periodontitis combined with diabetes group and diabetic group, respectively. There was no significant difference in periodontal clinical indexes between the periodontitis group and the periodontitis combined with diabetes group, and the comparison of biochemical indexes between the periodontitis group and the periodontitis combined with diabetes group was compared with that of the control group. There was no significant difference in low density lipoprotein (LDL-C) levels between the periodontitis group and the healthy group. There was no significant difference in glycosylated hemoglobin, fasting blood glucose and high density lipoprotein level between the diabetic group and the periodontitis with diabetes group. The level of fasting blood glucose was higher than that of periodontitis group and healthy group (P < 0.01), and the high density lipoprotein (HDL) level in diabetes group and periodontitis complicated diabetes group was lower than that in healthy group (P < 0.05). There was no significant difference in glycosylated hemoglobin, fasting blood glucose and high density lipoprotein levels between diabetic group and periodontitis complicated with diabetes group. The comparison of MDAs and SOD levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in each group: diabetic group, The serum MDA and SOD levels in periodontitis with diabetes group were significantly higher than those in periodontitis group, and the difference was statistically significant in healthy group. The levels of MDA and SOD in diabetes group were the highest, and MDA level in healthy group was the lowest. In periodontitis group, the level of SOD was the lowest. 4, malondialdehyde (MDA) and superoxide dismutase (SOD) were correlated with other clinical indexes: malondialdehyde (MDA) and superoxide dismutase (SOD), glycosylated hemoglobin (HbHb), fasting blood glucose (FBG), triglyceride (TG) were positively correlated with age. Superoxide dismutase (SOD) was positively correlated with malondialdehyde (MDA), glycosylated hemoglobin (HbHb), fasting blood glucose (FBG) and age, but positively correlated with high density lipoprotein (HDL). Conclusion the serum MDA-SOD levels in patients with type 1 diabetes mellitus and chronic periodontitis with type 2 diabetes mellitus are higher than those in patients with chronic periodontitis, and the levels of serum MDA in all subjects are significantly higher than those in patients with chronic periodontitis. With SOD, glycosylated hemoglobin, Fasting blood glucose, triglyceride and age were positively correlated. In all subjects, serum SOD levels were positively correlated with glycosylated hemoglobin, fasting blood glucose and age, high density lipoprotein, periodontal pocket depth. There was a negative correlation between periodontal attachment loss and periodontal attachment loss.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R781.42;R587.1

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