本文關(guān)鍵詞： 糖尿病足 貧血 預(yù)后　出處：《重慶醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：回顧分析糖尿病足潰瘍患者合并貧血的患病率、臨床特征及預(yù)后,并評估貧血對糖尿病足潰瘍預(yù)后的影響。材料和方法：回顧性的研究我院353名糖尿病足潰瘍患者,根據(jù)患者入院時有無貧血將其分為貧血組及非貧血組,比較兩組患者分別在人口統(tǒng)計學(xué)特征、實驗室檢查結(jié)果、糖尿病并發(fā)癥、合并癥、治療方案、糖尿病足潰瘍特征及預(yù)后等方面的差異。本研究的主要研究終點為良好結(jié)局(愈合)和不良結(jié)局(未愈合、截肢、死亡),次要研究終點為截肢以及死亡。結(jié)果：調(diào)查的353名糖尿病足潰瘍患者,平均年齡為66.44歲,其中236名合并貧血,所占比例為66.9%。單因素分析發(fā)現(xiàn)糖尿病足潰瘍合并貧血的患者多為男性,有吸煙史、血清白蛋白水平更低、腎功能更差、全身使用至少兩類抗生素、下肢的血流灌注更差、足潰瘍面積更大、深度更深、感染更重。多因素回歸分析表明,男性、血清白蛋白水平更低、腎功更差是糖尿病足潰瘍患者合并貧血的獨立危險因素。并通過多因素分析得出貧血是糖尿病足潰瘍不良結(jié)局的獨立危險因素。通過ROC曲線分析確定糖尿病足潰瘍患者易發(fā)生不良結(jié)局的血紅蛋白適宜切點為：女性12.3g/dL,男性12.1g/dL。結(jié)局：貧血在糖尿病足潰瘍患者中非常常見,盡管其中絕大多數(shù)為輕、中度貧血,但卻與糖尿病足潰瘍患者的病殘率及死亡率息息相關(guān)。
[Abstract]:Objective: to retrospectively analyze the prevalence, clinical characteristics and prognosis of diabetic foot ulcers complicated with anemia, and evaluate the influence of anemia on the prognosis of diabetic foot ulcers. Materials and methods: 353 diabetic foot ulcers were retrospectively studied in our hospital. According to whether the patient had anemia at admission, they were divided into anemia group and non-anemia group. The two groups were compared in terms of demographic characteristics, laboratory results, diabetic complications, complications, and treatment plans. The main endpoints of this study were good outcome (healing) and bad outcome (non-union, amputation, etc.). Results: the average age of 353 patients with diabetic foot ulcers was 66.44 years old, 236 of them complicated with anemia. Univariate analysis showed that the majority of diabetic foot ulcers complicated with anemia were male, had a history of smoking, had lower serum albumin levels, had worse renal function, used at least two kinds of antibiotics throughout the body, and had worse blood perfusion in the lower extremities. Foot ulcers were larger, deeper, and more infected. Multivariate regression analysis showed that men had lower levels of serum albumin. Kidney dysfunction is an independent risk factor for diabetic foot ulcer patients with anemia. Anemia is an independent risk factor for the adverse outcome of diabetic foot ulcers. ROC curve analysis is used to determine the diabetic foot ulcers. The optimal hemoglobin cutting point for patients with poor outcomes is: women 12.3g / dL, men 12.1g / dL. outcome: anemia is very common in patients with diabetic foot ulcers. Although most of them are mild and moderate anemia, they are associated with disability and mortality in patients with diabetic foot ulcers.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R587.2

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