本文關(guān)鍵詞： 抗菌治療 老年糖尿病 肺部感染 血清學(xué)指標(biāo)　出處：《中華醫(yī)院感染學(xué)雜志》2017年20期 　論文類型：期刊論文

【摘要】：目的探討不同抗菌治療方案對(duì)老年糖尿病合并肺部感染患者血清學(xué)指標(biāo)和療效的影響。方法選取醫(yī)院2014年4月-2016年2月應(yīng)用頭孢他啶聯(lián)合氨溴索治療的58例老年糖尿病合并肺部感染患者為觀察組,頭孢噻肟鈉聯(lián)合氨溴索治療的60例患者作為對(duì)照組,比較兩組用藥前后血清學(xué)指標(biāo)的變化,同時(shí)在用藥10d后對(duì)療效和藥物不良反應(yīng)。結(jié)果治療后兩組血清內(nèi)皮素(ET)、C-反應(yīng)蛋白(CRP)、白細(xì)胞計(jì)數(shù)(WBC),降鈣素基因相關(guān)肽(CGRP)與治療前差異有統(tǒng)計(jì)學(xué)意義(P0.05),觀察組CD_4~+/CD_8~+明顯改善,對(duì)照組CD_4~+/CD_8~+無(wú)明顯改善,治療后觀察組ET、CRP、WBC、CGRP、CD_4~+/CD_8~+分別為(41.63±5.17)ng/L、(51.39±8.67)mg/L、(8.37±4.25)×10~9/L、(67.53±5.43)ng/L、(1.56±0.23)表達(dá)水平顯著優(yōu)于對(duì)照組(58.37±6.03)ng/L、(87.69±8.75)mg/L、(11.68±4.37)×10~9/L、(50.34±4.56)ng/L、(1.04±0.15)(P0.05);觀察組總有效率為82.76%顯著高于對(duì)照組66.67%(P0.05);觀察組并發(fā)癥發(fā)生率為8.62%明顯低于對(duì)照組16.67%(P0.05)。結(jié)論頭孢他啶聯(lián)合氨溴索作為廣譜殺菌方案,不僅能顯著抑制血清炎性因子表達(dá),能有益調(diào)節(jié)免疫功能。
[Abstract]:Objective to investigate the effect of different antimicrobial regimens on serological indexes and efficacy in elderly patients with diabetes mellitus complicated with pulmonary infection. Methods 58 elderly patients treated with ceftazidime combined with ambroxol from April 2014 to February 2016 were selected. Patients with diabetes complicated with pulmonary infection were treated as observation group. 60 patients treated with cefotaxime sodium combined with ambroxol were used as control group to compare the changes of serological indexes before and after treatment. Results after 10 days of treatment, there were significant differences between the two groups in serum endothelin (et), C-reactive protein (CRP), white blood cell count (WBCU), calcitonin gene-related peptide (CGRP) and pre-treatment (P 0.05). In the control group, CD4 ~ / CD8 had no significant improvement, After treatment, the expression levels of ETCRP- WBCC- CGRPnP + CD4 ~ /-CD8 in the observation group were 41.63 鹵5.17 ng / L, 51.39 鹵8.67 mg / L, 8.37 鹵4.25) 脳 10 ~ 9 mg / L respectively, 67.53 鹵5.43 ng / L ~ (1.56 鹵0.23) and 58.37 鹵6.03 ng / L ~ (-1. 56 鹵0.23) respectively; the incidence of complications in the observation group was significantly higher than that in the control group (58.37 鹵6.03 ng / L = 11.68 鹵4.37) 脳 10 ~ (9) Lng / L = 50.34 鹵4.56ng / L = 1.04 鹵0.15ng / L / L ~ (1.04) 鹵0.15ng / L respectively; the overall effective rate in the observation group was significantly higher than that in the control group (66.37 鹵6.03ng / L) and the incidence of complications in the observation group was significantly lower than that in the control group. Conclusion the incidence of complications in the observation group is significantly lower than that in the control group. Conclusion the incidence of complications in the observation group is significantly lower than that in the control group. Conclusion the incidence of complications in the observation group is significantly higher than that in the control group. Conclusion the incidence of complications in the observation group is significantly lower than that in the control group. As a broad-spectrum bactericidal scheme, Not only can significantly inhibit the expression of serum inflammatory factors, can be beneficial to regulate the immune function.
【作者單位】： 遵義市第一人民醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R563.1;R587.2

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 許先榮;老年急性肺部感染患者血小板四項(xiàng)參數(shù)檢測(cè)的臨床意義[J];臨床內(nèi)科雜志;1998年06期

2 程亦斌,朱廣友;肺結(jié)核合并肺部感染患者死亡糾紛分析[J];中國(guó)醫(yī)刊;2001年02期

3 趙明聰;肺結(jié)核并肺部感染患者的藥敏分析[J];嶺南急診醫(yī)學(xué)雜志;2003年01期

4 高文軍,衛(wèi)敏,顧琳;肺結(jié)核合并肺部感染患者的序貫抗感染治療[J];廣東醫(yī)學(xué);2005年05期

5 陳麗;葉盛開;;誘導(dǎo)痰在肺部感染患者中的應(yīng)用[J];實(shí)用醫(yī)學(xué)雜志;2008年06期

6 沈小燕;陳剛;林麗香;;2型糖尿病合并肺部感染患者臨床分析[J];中國(guó)糖尿病雜志;2009年12期

7 韓京軍;;急性肺部感染患者血清超氧化物歧化酶及丙二醛檢測(cè)的臨床意義[J];時(shí)珍國(guó)醫(yī)國(guó)藥;2010年02期

8 李紹環(huán);楊艷麗;;70例肺部感染患者臨床治療探討[J];中國(guó)現(xiàn)代藥物應(yīng)用;2010年07期

9 王彩鳳;朱聰智;齊發(fā)梅;;肺部感染患者血清中血管緊張素轉(zhuǎn)換酶檢測(cè)的意義[J];中國(guó)衛(wèi)生檢驗(yàn)雜志;2013年05期

10 喬桂蘭,趙才;48例肺部感染患者軍團(tuán)菌血清學(xué)研究[J];長(zhǎng)治醫(yī)學(xué)院學(xué)報(bào);1996年04期

相關(guān)會(huì)議論文 前8條

1 張家洪;;肺部感染患者痰培養(yǎng)和藥敏結(jié)果分析[A];中華醫(yī)學(xué)會(huì)第12次全國(guó)內(nèi)科學(xué)術(shù)會(huì)議論文匯編[C];2009年

2 謝淑蘭;;肺部感染患者繼發(fā)真菌感染的種類和藥敏分析[A];中華醫(yī)學(xué)會(huì)第八次全國(guó)檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議暨中華醫(yī)學(xué)會(huì)檢驗(yàn)分會(huì)成立30周年慶典大會(huì)資料匯編[C];2009年

3 劉宏;吳雄飛;朱方強(qiáng);趙洪雯;余榮杰;;嚴(yán)重肺部感染患者停用免疫抑制劑的安全性評(píng)價(jià)[A];2013中國(guó)器官移植大會(huì)論文匯編[C];2013年

4 曹蘇紅;;肺部感染患者臨床治療過(guò)程中藥師的服務(wù)[A];2013年中國(guó)臨床藥學(xué)學(xué)術(shù)年會(huì)暨第九屆臨床藥師論壇論文集[C];2013年

5 段寶霞;方潔;;1例呼吸衰竭伴肺部感染患者的藥學(xué)監(jiān)護(hù)[A];2013年中國(guó)臨床藥學(xué)學(xué)術(shù)年會(huì)暨第九屆臨床藥師論壇論文集[C];2013年

6 馮勇智;劉加良;呂曉東;張齊;倪丹;莊延兵;;前降鈣素與C反應(yīng)蛋白在肺部感染患者中的表達(dá)[A];中華醫(yī)學(xué)會(huì)第11屆全國(guó)內(nèi)科學(xué)術(shù)會(huì)議論文匯編[C];2007年

7 馮勇智;劉加良;呂曉東;張齊;倪丹;莊延兵;;前降鈣素與C反應(yīng)蛋白在肺部感染患者中的表達(dá)[A];華東地區(qū)第6屆中青年呼吸醫(yī)師論壇暨浙江省第29屆呼吸疾病學(xué)術(shù)年會(huì)論文匯編[C];2007年

8 段志強(qiáng);許亞宏;馬小平;李健;盧奕;李陽(yáng)波;郭瑜;譚娟;劉洋;;147例腎移植術(shù)后并發(fā)肺部感染患者的治療體會(huì)[A];2013中國(guó)器官移植大會(huì)論文匯編[C];2013年

相關(guān)碩士學(xué)位論文 前1條

1 徐秀梅;老年肺部感染患者營(yíng)養(yǎng)及免疫狀況分析研究[D];吉林大學(xué);2017年

，

本文編號(hào)：1529752