本文關(guān)鍵詞： 熱射病 動物模型 心肌損傷 氧化應激 死亡率　出處：《中國現(xiàn)代醫(yī)學雜志》2017年14期 　論文類型：期刊論文

【摘要】：目的復制熱射病(HS)大鼠模型,探討HS大鼠死亡危險因素及心肌損傷情況。方法雄性無特定病原體級SD大鼠48只,隨機分為對照組、HS組、維生素E組(HS維生素E處理)、纈沙坦組(HS纈沙坦處理),每組12只;除對照組外,余組給予40℃、(65±1)%濕熱打擊,達復制模型標準后終止;心肌蘇木精-伊紅染色法(HE)染色及透射電鏡觀察病理變化。結(jié)果對照組體重變化率與其余3組比較,差異有統(tǒng)計學意義(P0.05),HS組血清乙酰膽堿(Ach)含量為(9.958±4.283)μg/ml,對照組為(15.734±4.987)μg/ml,兩組比較,差異有統(tǒng)計學意義(P0.05);HE染色和透射電鏡結(jié)果顯示,HS大鼠存在心肌損傷,且維生素E組、纈沙坦組大鼠心肌損傷程度較HS組減輕。結(jié)論死亡事件主要發(fā)生在發(fā)病后24 h內(nèi),且低體溫和較長打擊時間是大鼠死亡的主要危險因素,但相對較高的體重變化率是大鼠存活的保護因素;HS大鼠存在心肌損傷,其潛在機制可能是氧化應激和血管緊張素Ⅱ誘導的心肌細胞凋亡。
[Abstract]:Objective to study the risk factors of death and myocardial injury in HS rats. Methods 48 male SD rats with no specific pathogen were randomly divided into control group and HS group. Vitamin E group treated with HS vitamin E and valsartan group treated with HS valsartan with 12 rats in each group. Results compared with the other three groups, the serum acetylcholine acetylcholine (ache) content in the control group was 9.958 鹵4.283 渭 g / ml, and the control group was 15.734 鹵4.987 渭 g / ml. The results of HE staining and transmission electron microscope showed that there was myocardial injury in HS rats, and the degree of myocardial injury in vitamin E group and valsartan group was less than that in HS group. Hypothermia and long hit time were the main risk factors of rat death, but the relatively high rate of body weight change was the protective factor of survival in HS rats. The underlying mechanism may be oxidative stress and angiotensin 鈪，

本文編號：1512128