本文關(guān)鍵詞： 圍絕經(jīng)期 潮熱 雌激素 細(xì)胞色素P 基因多態(tài)性　出處：《第三軍醫(yī)大學(xué)學(xué)報(bào)》2016年14期 　論文類型：期刊論文

【摘要】：目的研究性激素水平及雌激素代謝酶相關(guān)基因細(xì)胞至色素P450(cytochrome P450,CYP)多態(tài)性對(duì)圍絕經(jīng)期婦女潮熱易感性的影響。方法選取2006年10月至2008年5月西安交通大學(xué)第一附屬醫(yī)院體檢中心進(jìn)行健康體檢的328名圍絕經(jīng)期婦女進(jìn)行病例對(duì)照研究,將其分為潮熱組(n=156)和無潮熱組(n=172)。采用放免法測(cè)定血清卵泡刺激素(follicle stimulating hormone,FSH)、黃體生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)和睪酮(testosterone,T),酶免法測(cè)定性激素結(jié)合球蛋白(sex hormone binding globulin,SHBG)和硫酸脫氫表雄酮(dehydroepiandrosterone sulfate,DHEA-S)。應(yīng)用聚合酶鏈反應(yīng)-限制性片段長度多態(tài)性方法分析兩組婦女CYP17 Msp A1Ⅰ、CYP19Rsa I、CYP1A1 Msp I和CYP1B1 Eco57I基因多態(tài)性。結(jié)果與無潮熱組婦女比較,潮熱組婦女血清FSH水平增高(P0.01),而E2和SHBG水平降低(P0.05)。CYP1B1 Eco57I基因多態(tài)性在潮熱組和無潮熱組婦女中的分布差異有統(tǒng)計(jì)學(xué)意義(P0.05);攜帶CYP1B1 Eco57I基因多態(tài)性的婦女潮熱發(fā)生的風(fēng)險(xiǎn)為未攜帶婦女的1.25倍(OR=1.25,95%CI:1.03~1.82);中重度潮熱發(fā)生及潮熱持續(xù)時(shí)間1年的風(fēng)險(xiǎn)分別為未攜帶婦女的1.28倍和1.35倍。結(jié)論血清E2水平降低可能是潮熱發(fā)生的原因之一。CYP1B1 Eco57I基因多態(tài)性增加?jì)D女潮熱發(fā)生、潮熱程度和持續(xù)時(shí)間的風(fēng)險(xiǎn)。
[Abstract]:Objective to study the level of sex hormone and the cytochrome P450 in cytochrome P450 cells associated with estrogen metabolism enzyme. Cyp). The effect of polymorphism on the predisposition of peri-menopausal women to hot flashes. Methods from October 2006 to May 2008, the physical examination center of the first affiliated Hospital of Xi'an Jiaotong University was selected to conduct physical examination in 328 postmenopausal women. A case-control study was conducted among women. The serum follicle stimulating hormone (FSH) was determined by radioimmunoassay (RIA). Follicle stimulating hormone. FSHG, luteinizing hormone, estradiolone E2) and testosterone testosterone. Hormone binding globulin of sex hormone binding globulin was determined by enzyme immunoassay. Sulfate and dehydroepiandrosterone sulfate dehydroepiandrosterone sulfate. CYP17 Msp A1 鈪，

本文編號(hào)：1476815