本文關(guān)鍵詞：絕經(jīng)后骨量減少女性骨代謝相關(guān)指標(biāo)的研究　出處：《首都體育學(xué)院》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 絕經(jīng)女性 骨質(zhì)疏松 骨量減少 血清素 鳶尾素

【摘要】：目的:骨質(zhì)疏松癥是女性絕經(jīng)后面臨的一種常見疾病,隨著社會(huì)人口平均壽命的提高和老齡化進(jìn)程的加劇,其發(fā)病率在逐年上升。骨量減少期是骨質(zhì)疏松患者從健康骨量發(fā)展到骨質(zhì)疏松的過渡階段。本實(shí)驗(yàn)的目的是探討絕經(jīng)后骨量減少女性的絕經(jīng)年限、體成分、骨代謝相關(guān)血清指標(biāo)的變化規(guī)律,及其與骨密度的相關(guān)性,旨在為減緩絕經(jīng)女性骨量流失,預(yù)防其骨質(zhì)疏松的發(fā)生提供指導(dǎo)性建議。方法:在對(duì)80位受試者進(jìn)行年齡,絕經(jīng)年限,初潮年齡,月經(jīng)年限,日常體力活動(dòng),睡眠狀況,飲食結(jié)構(gòu),病史以及手術(shù)史等內(nèi)容問卷調(diào)查的基礎(chǔ)上,對(duì)受試者進(jìn)行全身和局部骨密度測試后,根據(jù)腰椎1-4節(jié)骨密度的T值將受試者分為骨量正常組(T-score≥-1)和骨量減少組(-2.5≤T-score-1)。空腹抽取受試者肘靜脈血5-10ml,提取出血清后,用比色法檢測血清堿性磷酸酶(AKP)、抗酒石酸酸性磷酸酶(STRACP),血脂四項(xiàng)(總膽固醇TCH,甘油三酯TG,高密度脂蛋白HDL-C,低密度脂蛋白LDL-C)的含量;用ELISA檢測血清中血清素(Serotonin)和鳶尾素(Irisin)的含量。使用SPSS22.0對(duì)骨密度(BMD)與其他指標(biāo)間進(jìn)行相關(guān)性分析,對(duì)不同骨量組進(jìn)行組間骨密度,血清指標(biāo),體成分,絕經(jīng)年限的差異顯著性分析。結(jié)果:1.骨量減少組受試者血清AKP、STRACP、TCH、TG、HDL-C,LDL-C、Serotonin、Irisin的含量與骨量正常組差異無統(tǒng)計(jì)學(xué)意義。2.骨量減少組受試者的體重、BMI、基礎(chǔ)代謝率顯著低于骨量正常組,但BMI與BMD間無相關(guān)性,而基礎(chǔ)代謝率與BMD間有顯著相關(guān)性。3.骨量減少組受試者的絕經(jīng)年限顯著高于骨量正常組,且與BMD間有相關(guān)性。結(jié)論:絕經(jīng)年限是影響絕經(jīng)女性骨密度的關(guān)鍵因素。絕經(jīng)后骨量減少的女性,其體重、BMI和基礎(chǔ)代謝率均顯著降低,而血清中AKP,STRACP,TCH,TG,HDL-C,LDL-C,Serotonin,Irisin的含量沒有顯著變化。
[Abstract]:Objective: osteoporosis is a common disease in postmenopausal women, with the increase of average life expectancy and the aggravation of aging process. The incidence of bone mass is increasing year by year. The period of osteopenia is the transition stage from healthy bone mass to osteoporosis. The purpose of this study was to investigate the menopausal age and body composition of postmenopausal women. The changes of serum indexes related to bone metabolism and their correlation with bone mineral density were designed to slow down bone loss in menopausal women. Methods: 80 subjects were given age, menopausal age, menarche age, menstrual age, daily physical activity, sleep status and dietary structure. Based on the questionnaire survey of the history of disease and operation, the bone mineral density of the subjects was measured. The subjects were divided into normal bone mass group (T score 鈮，

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