本文關(guān)鍵詞：生脈注射液聯(lián)合格列美脲治療氣陰兩虛型2型糖尿病的臨床療效及對患者血清炎性因子的影響　出處：《中國實驗方劑學(xué)雜志》2016年04期 　論文類型：期刊論文

  更多相關(guān)文章： 生脈注射液 格列美脲 型糖尿病 糖化血紅蛋白 白細胞介素-β

【摘要】：目的:探討生脈注射液聯(lián)合格列美脲治療氣陰兩虛型2型糖尿病的臨床效果及對血清炎性因子的影響。方法:選取2013年2月—2015年2月來濱州市中醫(yī)醫(yī)院就診的2型糖尿病患者152例,采用隨機數(shù)字法分為觀察組77例和對照組75例。對照組給予格列美脲進行治療,觀察組在對照組治療的基礎(chǔ)上聯(lián)合生脈注射液治療。觀察比較兩組患者的臨床有效率,空腹血糖(FBG),餐后2 h血糖(2 h PBG),糖化血紅蛋白(Hb A1c)的改變及血清高敏C反應(yīng)蛋白(hs-CRP),腫瘤壞死因子-α(TNF-α),白細胞介素-1β(IL~(-1)β)水平變化及不良反應(yīng)情況。結(jié)果:觀察組總有效率92.21%,明顯高于對照組的78.67%(P0.05)。兩組FBG[(5.87±0.32)VS(10.63±0.53)mmol·L~(-1)],2 h PBG[(6.52±1.22)VS(11.24±2.72)mmol·L~(-1)],Hb A1c[(4.42±0.37)%VS(6.21±0.52)%]比較,觀察組明顯低于對照組(P0.05)。治療后,兩組患者的hs-CRP,TNF-α,IL~(-1)β水平顯著降低(P0.05),且兩組hs-CRP[(2.25±0.73)VS(3.37±1.01)g·L~(-1)],TNF-α[(1.56±0.47)VS(2.23±0.44)ng·L~(-1)],IL~(-1)β[(15.36±3.70)VS(22.94±3.81)ng·L~(-1)]比較,觀察組水平明顯低于對照組(P0.05)。兩組患者治療期間不良反應(yīng)主要為嘔吐、腹瀉和低血糖,經(jīng)對癥治療后均痊愈,不良反應(yīng)發(fā)生率比較差異無統(tǒng)計學(xué)意義。結(jié)論:生脈注射液聯(lián)合格列美脲治療氣陰兩虛型2型糖尿病的療效明顯,同時可降低患者體內(nèi)炎性因子的水平,從而可能延緩氣陰兩虛型2型糖尿病并發(fā)癥的發(fā)生,值得臨床推廣使用。
[Abstract]:Objective: To investigate the clinical effect of Shengmai injection combined with glimepiride in the treatment of type 2 diabetes of Qi Yin deficiency and effect on serum inflammatory factors. Methods: 152 patients with type 2 diabetes from February 2013 to February 2015 to visit Binzhou City Chinese medicine hospital were divided into observation group 77 cases and control group 75 cases randomly. The control group given glimepiride treatment, the observation group of Shenmai injection combined with students on the basis of the control group. The clinical treatment of the two groups were observed and compared with the efficiency of fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PBG), glycosylated hemoglobin (Hb A1c) and changes of serum high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF- alpha), interleukin -1 (IL~ (-1) 3) level changes and adverse reactions. Results: the total efficiency of the observation group was 92.21%, significantly higher than the control group 78.67% (P0.05). Two groups of FBG[(5.87 + 0.32) VS (10.63. 0.53)mmol路L~(-1)],2 h PBG[(6.52鹵1.22)VS(11.24鹵2.72)mmol路L~(-1)],Hb A1c[(4.42鹵0.37)%VS(6.21鹵0.52)%]姣旇緝,瑙傚療緇勬槑鏄句綆浜庡鐓х粍(P0.05).娌葷枟鍚，

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