背景2010年全球約有2.85億人患有糖尿病,預(yù)計(jì)到2030年糖尿病患病人數(shù)將增加至4.39億,相當(dāng)于全球7.7%的20-49歲成年人的數(shù)量,大約90%的糖尿病為2型糖尿病。2型糖尿病的高血糖狀態(tài)會(huì)導(dǎo)致血管、神經(jīng)及器官的損傷。盡管中度的血糖升高不會(huì)使機(jī)體出現(xiàn)任何癥狀,但長期的高血糖會(huì)損傷機(jī)體,導(dǎo)致糖尿病并發(fā)癥,如心腦血管疾病、神經(jīng)損傷、糖尿病視網(wǎng)膜病變、糖尿病腎病等。如果腎臟小血管堵塞,空隙增大,腎臟的生理功能就會(huì)出現(xiàn)損害。傳統(tǒng)觀點(diǎn)認(rèn)為,代謝和血液因素是引起糖尿病腎病的主要因素,新的研究顯示,炎癥在糖尿病腎病的進(jìn)展中發(fā)揮重要作用,T細(xì)胞可能參與糖尿病腎病的發(fā)生和發(fā)展。CD4+輔助T細(xì)胞(Th)在調(diào)節(jié)免疫反應(yīng)中發(fā)揮重要作用,最近有研究顯示,除了Th1/Th2失衡以外,Th17/Treg失衡在一些自身免疫病、炎癥性疾病和代謝性疾病如2型糖尿病中發(fā)揮重要作用。肥胖是已知的導(dǎo)致2型糖尿病進(jìn)展的主要危險(xiǎn)因素之一,而且肥胖與低度炎癥相關(guān)。目的探討2型糖尿病病人肥胖和是否存在Th17/Treg失衡及其與促炎因子和抗炎因子的相關(guān)性。研究設(shè)計(jì)本研究招募110名2型糖尿病病人,以尿白蛋白/肌酐比率(UCA...

【文章頁數(shù)】：81 頁

【學(xué)位級別】：博士

【文章目錄】：
中文摘要 Abstract Abbreviations And Acronyms Introduction 1. Th17 And Treg Cells In Study Participants
1.1 Material
    1.1.1 Reagent And Kits
    1.1.2 Chemicals
    1.1.3 Equipment
1.2 Methods
    1.2.1 Study Subjects And Materials
    1.2.2 Specimen
    1.2.3 Cell Preparation Analysis
    1.2.4 Surface Staining Protocol
    1.2.5 Intracellular Staining Protocol
    1.2.6 Ethical Consideration
    1.2.7 Statistical Analysis
1.3 Results
    1.3.1 Baseline Characteristics
    1.3.2 Metabolic Panel Characteristics
    1.3.3 Th17 Cells
    1.3.4 Treg Cells
    1.3.5 Th17/Treg Cells Ratio
1.4 Discussion
1.5 Summary 2. Serum Cytokines In Type 2 Diabetic Patients
2.1 Material
    2.1.1 Reagent And Kits
    2.1.2 Chemicals
    2.1.3 Equipment
2.2 Methods
    2.2.1 Study Subjects And Materials
    2.2.2 Specimen
    2.2.3 Cytokine Measurement
    2.2.4 Ethical Consideration
    2.2.5 Statistical Analysis
2.3 Result
    2.3.1 Serum Cytokines
    2.3.2 Il -6 In Study Participants
    2.3.3 Il-10 In Study Participants
    2.3.4 Il-21 In Study Participants
    2.3.5 Il-23 In Study Participants
    2.3.6 Tgf-Β1 In Study Participants
2.4 Discussion
2.5 Summary Conclusion Innovative Study Limitations References Publication And Project Review The Roles of Th17 and Treg Cells in Inflammatory Diseases
Introduction
1. Treg Cells
2. Differentiation Of Treg Cells
    2.1 Natural Treg Cells
    2.2 Inducible Treg Cells
3. Tregs And Involved Cytokines
4. Th17 Cells
5. Th17 Cells And Cytokines
6. Th17/Treg Balance And Diseases
7. Conclusion
Review References Acknowledgements 個(gè)人簡歷



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