目的:鑒定去勢(shì)抵抗性前列腺癌（CRPC）的關(guān)鍵基因。創(chuàng)新點(diǎn):（1）結(jié)合多個(gè)數(shù)據(jù)庫(kù)數(shù)據(jù),運(yùn)用生物信息學(xué)方法鑒定CRPC的關(guān)鍵基因;（2）首次報(bào)道PTPRR可能在CRPC里起關(guān)鍵作用。方法:通過下載三個(gè)GEO數(shù)據(jù)庫(kù)的m RNA微陣列數(shù)據(jù),分析CRPC和激素敏感前列腺癌之間的基因差異,對(duì)篩選出的差異基因進(jìn)行功能富集分析和蛋白質(zhì)間相互作用分析,最終篩選出兩個(gè)有重要功能的差異基因（PTPRR和JAG1）。通過在多個(gè)其他數(shù)據(jù)庫(kù)中進(jìn)行表達(dá)量驗(yàn)證和生存分析,進(jìn)一步證明這些基因的重要作用。結(jié)論:PTPRR和JAG1在CRPC中顯著增高,并與預(yù)后差相關(guān)。因此,這兩個(gè)基因有可能作為CRPC的診斷和預(yù)后的生物標(biāo)志物。 

【文章來源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(03)SCICSCD

【文章頁(yè)數(shù)】：12 頁(yè)

【文章目錄】：
1 Introduction
2 Materials and methods
    2.1 Microarray data
    2.2 Identification of DEGs
    2.3 Functional enrichment analysis of the DEGs
    2.4 PPI network construction and analysis
    2.5 Expression validation and survival analysis of the key genes
3 Results
    3.1 DEG identification
    3.2 GO and KEGG pathway enrichment
    3.3 Construction of PPI network
    3.4 Identification of key gene signatures in CRPC and survival analysis
4 Discussion
5 Conclusions
Data availability
Contributors
Compliance with ethics guidelines
List of electronic supplementary materials
Identification of PTPRR and JAG1 as key genes in castration-resistant prostate cancer by integrated bioinformatics methods


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