【摘要】：目的分析不同的血紅蛋白目標(biāo)值對維持性血液透析(MHD)患者生存質(zhì)量及病死率的影響。方法選擇在河北省衡水市血液透析中心連續(xù)門診透析6個月以上的年齡為18~80歲的320例終末期腎病患者(ESRD),分為3組,分別制訂高、中、低3個血紅蛋白目標(biāo)值,A組:95~110g/L,B組:110~125g/L,C組:125~140g/L。各組分別給予藥物干預(yù)糾正貧血,并達(dá)到各自目標(biāo)值,觀察隨后72周的生化、凝血相關(guān)指標(biāo),試驗(yàn)結(jié)束后對患者進(jìn)行SF-36生存質(zhì)量的測評,進(jìn)而分析不同血紅蛋白目標(biāo)值與患者生存質(zhì)量及病死率的影響。結(jié)果試驗(yàn)前,3組各項(xiàng)化驗(yàn)指標(biāo)差異無統(tǒng)計(jì)學(xué)意義(P0.05),而藥物干預(yù)后第12周開始同一時期中A組的血清清蛋白(ALB)、前清蛋白(pre ALB)均低于B、C組,C-反應(yīng)蛋白(CRP)則高于B、C組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),而3組間的纖維蛋白原(FB)及B、C兩組的CRP、血清ALB和pre ALB水平則差異無統(tǒng)計(jì)學(xué)意義(P0.05)。B、C組患者SF-36量表測評優(yōu)于A組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),而B、C組之間比較差異則無統(tǒng)計(jì)學(xué)意義(P0.05)。試驗(yàn)結(jié)束后3組病死率差異無統(tǒng)計(jì)學(xué)意義(χ~2=0.467,P=0.792)。結(jié)論貧血的糾正與MHD患者的生化、凝血、血清ALB和pre ALB及生存質(zhì)量關(guān)系密切,血紅蛋白目標(biāo)值的設(shè)定更應(yīng)根據(jù)患者的具體情況來制訂。
[Abstract]:Objective to analyze the effect of different hemoglobin target values on quality of life (QOL) and mortality of (MHD) patients with maintenance hemodialysis. Methods 320 patients aged 18 鹵80 years old with end-stage renal disease (ESRD),) were divided into three groups: group A (95 g / L), group B (110 g / L), group C (125 g / L), group A (95 g / L), group B (110 g / L), group C (125 g / L) and group C (125 鹵140 g 路L ~ (- 1), which were divided into three groups: group A (95 g / L) and group B (110 g / L). Each group was given drug intervention to correct anemia and reached its own target value. The biochemical and coagulation related indexes were observed at the end of the experiment, and the quality of life of SF-36 was evaluated after the trial, and then the effects of different hemoglobin target values on quality of life and mortality of patients were analyzed. Results before the test, there was no significant difference in the laboratory indexes among the three groups (P 0.05), but the serum albumin (ALB), proalbumin (pre ALB) in group A was lower than that in group B, while the C-reactive protein (CRP) in group C was higher than that in group B, and the difference was statistically significant (P 0.05). However, the levels of fibrin (FB) and CRP, in group C and group C were significantly lower than those in group B and group C (P 0.05), but the levels of serum albumin (CRP) in group A and group C were significantly lower than those in group B and group C (P < 0.05). There was no significant difference in serum ALB and pre ALB levels (P 0.05). The SF- 36 scale of group B and C was better than that of group A, the difference was statistically significant (P 0.05), but there was no significant difference between group C and group C (P 0.05). There was no significant difference in mortality among the three groups after the end of the trial (蠂 ~ 2 = 0.467, P 鈮，

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