發(fā)布時(shí)間：2019-06-02 13:04

【摘要】：為了探討終末期腎病(ESRD)患者血清成纖維細(xì)胞生長(zhǎng)因子23(FGF-23)水平與心血管鈣化的關(guān)系。我們選取了2015年9月~2016年5月在我院各科室接受治療的ESRD患者68例為實(shí)驗(yàn)組,選取46例健康成年人為對(duì)照組。使用超聲和腹部X線平片對(duì)心血管和腹主動(dòng)脈血管鈣化情況進(jìn)行評(píng)定,同時(shí)測(cè)量成纖維細(xì)胞生長(zhǎng)因子23(FGF-23)、血清肌酐(Scr)、鈣(Ca)、磷(P)、堿性磷酸酶(ALP)、總膽固醇(TC)、三酰甘油(TG)、血紅蛋白(HB)、甲狀旁腺激素(i PTH)各項(xiàng)指標(biāo)的含量。ESRD組患者FGF-23水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(p0.05),ESRD組患者FGF-23水平與Scr、P、iPTH、ALP呈正相關(guān)(r=0.423~0.687),與Ca、TC、TG、HB無相關(guān)性(r=-0.014~-0.113)。鈣化組患者FGF-23水平高于非鈣化組,差異有統(tǒng)計(jì)學(xué)意義(p0.05)。ESRD患者血清FGF-23水平的升高與心血管鈣化的發(fā)生發(fā)展密切相關(guān)。
[Abstract]:To investigate the relationship between serum fibroblasts growth factor 23 (FGF-23) and cardiovascular calcification in patients with end-stage renal disease (ESRD). From September 2015 to May 2016, 68 patients with ESRD who received treatment in various departments of our hospital were selected as the experimental group and 46 healthy adults as the control group. The calcification of cardiovascular and abdominal aortic vessels was evaluated by ultrasound and abdominal X-ray plain film, and fibroblasts growth factor 23 (FGF-23) and serum creatine (Scr), calcium (Ca), phosphorus (P), were measured at the same time. The content of alkaline phosphatase (ALP), total cholesterol (TC), triacylglycerol (TG), hemoglobin (HB), parathyroid hormone (i PTH). The level of FGF-23 in ESRD group was higher than that in control group. The difference was statistically significant (p0.05), ESRD group) FGF-23 level was positively correlated with Scr,P,iPTH,ALP (r 鈮，

本文編號(hào)：2491121