不同類型睪丸微石癥與成年男性精子質(zhì)量關(guān)系的探究
發(fā)布時(shí)間：2019-05-28 15:58
【摘要】：研究背景及目的 睪丸微石癥(Testicular microlithiasis, TM)作為臨床上比較少見的一種男性生殖系統(tǒng)疾病,特點(diǎn)是彌散分布于睪丸實(shí)質(zhì)內(nèi)的多發(fā)點(diǎn)狀鈣化。在臨床工作中,睪丸微石癥�？梢苑譃閮煞N不同的疾病類型：即限制型睪丸微石癥(Limited testicular microlithiasis, LTM)和經(jīng)典型睪丸微石癥(Classic testicular microlithiasis, CTM)。目前的研究對(duì)于TM發(fā)生率有逐漸升高的趨勢(shì)已經(jīng)逐步達(dá)成共識(shí)。當(dāng)前,多數(shù)研究者傾向于將TM視為一種與男性生精功能有關(guān)的、具有臨床意義的生殖系統(tǒng)疾病。針對(duì)TM包括其兩種不同類型(CTM和LTM)的具體病因、發(fā)病機(jī)制等等而言,特別是和男性生育功能的關(guān)系,已經(jīng)引起了很多研究者和臨床醫(yī)生的重視。因此,探討睪丸微石癥及其不同類型(CTM/LTM)和成年男性精子質(zhì)量之間的關(guān)系是一項(xiàng)非常重要并有臨床意義的研究,分析其相關(guān)性以及不同類型之間是否具有差異,可為今后臨床工作中診療決策的實(shí)施提供幫助。 資料與方法 1.回顧性分析41例經(jīng)超聲檢查診斷為睪丸微石癥,并且精液常規(guī)檢查發(fā)現(xiàn)精子的成年男性患者(即TM組)的臨床資料。全部41例患者分為經(jīng)典型睪丸微石癥(CTM)和限制型睪丸微石癥(LTM)兩組。 2.另收集經(jīng)超聲檢查診斷不伴有睪丸微石癥并接受精液常規(guī)檢查發(fā)現(xiàn)精子的11例成年男性(即非TM組)的臨床資料進(jìn)行分析。 3.采用SPSS18.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)分析,兩組獨(dú)立樣本均數(shù)間的兩兩比較采用Student's t檢驗(yàn),多組獨(dú)立樣本均數(shù)間的比較采用單因素方差分析(One-Way ANOVA),以P0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果 1.全部41例TM患者中,共31例(75.61%)患者最終診斷為CTM,其他10例(24.39%)患者診斷為L(zhǎng)TM。 2.TM組平均年齡是29.49±4.97歲,平均體質(zhì)量指數(shù)(Body Mass Index, BMI)是25.39±4.07kg/m2,平均睪丸體積是16.94±3.59ml。其中CTM組的平均年齡是30.06±5.28歲,平均BMI是25.54±4.33kg/m2,平均睪丸體積是16.66±3.39ml；而LTM組的平均年齡是27.70±3.47歲,平均BMI是24.92±3.27kg/m2,平均睪丸體積是17.81±4.21ml。非TM組平均年齡是27.82±3.34歲,平均BMI是25.46±3.57kg/m2,平均睪丸體積是17.90±2.91ml。 3.TM組和非TM組兩組在精子濃度(48.59±25.44×106/ml vs.89.06±36.03×106/ml)、精子總數(shù)(182.95±127.72×106vs.309.92±123.15×106)和非前向運(yùn)動(dòng)精子率(12.17±5.21%vs.18.10±7.27%)等三個(gè)方面的比較,差異均有統(tǒng)計(jì)學(xué)意義(P=0.000,0.005,0.003)。 4.CTM組、LTM組和非TM組三組在精子濃度(44.89±26.14×106/ml vs.60.06±20.16×106/ml vs.89.06±36.03×106/ml)、精子總數(shù)(160.33±106.50×106vs.253.05±165.74×106vs.309.92±123.15×106)、精子總活力(53.37±21.43%vs.71.28±16.96%vs.70.77±21.61%)、前向運(yùn)動(dòng)精子率(41.47±17.79%vs.58.28±15.73%vs.52.67±20.19%)、非前向運(yùn)動(dòng)精子率(11.90±5.63%vs.13.00±3.71%vs.18.10±7.27%)和不活動(dòng)精子率(46.63±21.43%vs.28.72±16.96%vs.29.25±21.60%)等六個(gè)方面的比較,差異均有統(tǒng)計(jì)學(xué)意義(F=10.522,6.789,4.540,3.994,4.797,4.536; P=0.000,0.002,0.016,0.025,0.013,0.016)。 5.其中,CTM組與非TM組在精子濃度(44.89±26.14×106/ml vs.89.06±36.03×106/ml)、精子總數(shù)(160.33±106.50×106vs.309.92±123.15×106)、精子總活力(53.37±21.43%vs.70.77±21.61)、非前向運(yùn)動(dòng)精子率(11.90±5.63%vs.18.10±7.27%)和不活動(dòng)精子率(46.63±21.43%vs.29.25±21.60%)等五個(gè)方面的比較,差異均有統(tǒng)計(jì)學(xué)意義(P=0.000,0.001,0.021,0.003,0.021)。 6.同時(shí),LTM組與非TM組在精子濃度(60.06±20.16×106/ml vs.89.06±36.03×106/ml)和非前向運(yùn)動(dòng)精子率(13.00±3.71%vs.18.10±7.27%)等兩個(gè)方面的比較,差異均有統(tǒng)計(jì)學(xué)意義(P=0.020,0.047)。 7.此外,CTM組和LTM組在精子總數(shù)(160.33±106.50×106vs.253.05±165.74×106)、精子總活力(53.37±21.43%vs.71.28±16.96%)、前向運(yùn)動(dòng)精子率(41.47±17.79%vs.58.28±15.73%)和不活動(dòng)精子率(46.63±21.43%vs.28.72±16.96%)等四個(gè)方面的比較,差異均有統(tǒng)計(jì)學(xué)意義(P=0.043,0.021,0.013,0.021)。 結(jié)論 1.睪丸微石癥能夠影響到成年男性的精子質(zhì)量。 2.與限制型睪丸微石癥相對(duì)比,經(jīng)典型睪丸微石癥對(duì)成年男性精子質(zhì)量的影響更顯著。 3.睪丸微石癥和成年男性精子質(zhì)量之間存在關(guān)聯(lián),微石的程度與精子質(zhì)量之間呈現(xiàn)出負(fù)相關(guān)的關(guān)系。
[Abstract]:Background and purpose of the study Testicular microlithiasis (TM) is a rare disease of male reproductive system in the clinic. It is characterized by the diffusion of multiple point-like calcium in the essence of the testis. In clinical work, the microlithiasis of the testis can be divided into two different types of diseases, namely, restricted testicular microlithiasis (LTM) and classic testicle microlithiasis (CTM). ). The current study has gradually reached a total of a gradual increase in the incidence of TM At present, most of the researchers are inclined to regard the TM as a reproductive system that is relevant to the male's spermatogenic function and has a clinical significance. The relationship between the specific causes of the TM, including its two different types (CTM and LTM), the pathogenesis, and the like, in particular the male fertility function, has led to the weight of many researchers and clinicians Therefore, the study of the relationship between testicular microlithiasis and its different types (CTM/ LTM) and the quality of adult male sperm is a very important and clinically meaningful study to analyze its correlation and whether there is a difference between different types I can provide some help for the implementation of diagnosis and treatment decision in the future clinical work. Co., Ltd. Materials and Methods 1. Retrospective analysis of 41 cases of testicular microlithiasis diagnosed by an ultrasonic examination, and the semen was routinely examined for adult male patients (i.e., TM) of the sperm. The clinical data of all 41 patients were divided into typical testicular microlithiasis (CTM) and constrained testicular microlithiasis (L (TM) two groups.2. A further collection of 11 adult male (i.e., non-TM) male (i.e., non-TM) who were not accompanied by testicular microlithiasis and were routinely examined for semen were also collected. 3. The data of the bed was analyzed.3. The statistical analysis was carried out by using the SPSS18.0 statistical software. The two of the two groups of independent samples were tested by Student's t. The comparison between the number of independent samples and the number of independent samples was one-Way ANOVA. to be poor Results 1. In total of 41 patients with TM,31 (75.61%) of the total 41 patients were diagnosed as CTM and 10 other patients (24 The mean age of the (39%) patients was 29.49 to 4.97 years and the mean body mass index (BMI) was 25.39 to 4.07 kg/ m2 and the mean testis The volume was 16.94 to 3.59 ml. The mean age of the CTM group was 30.06 to 5.28 years, the mean BMI was 25.54 to 4.33 kg/ m2, the mean testis volume was 16.66 to 3.39 ml, and the mean age of the LTM group was 27.70 to 3.47 years, with an average BMI of 24.92 and 3.27 kg/ m2, with an average testis The mean age of the non-TM group was 27.82-3.34 years, the mean BMI was 25.46-3.57 kg/ m2, and the average testis The total sperm concentration (48.59, 25.44,106/ ml vs. 89.06-36.03-106/ ml), the total number of sperm (182.95% 127.72-106 vs. 309.92-123.15-106) and the non-anterior exercise sperm rate (12.17% 5.21% vs. 18.10% 7.27%) were statistically significant (P = 0 The sperm concentration (44.89, 26.14,106/ ml vs. 60.06, 20.16,106/ ml vs. 89.06, 36.03,106/ ml), total sperm count (160.33, 106.50,106 vs. 253.05, 165.74,106 vs. 309.92, 16.96% vs. 70.77 and 21.61% vs. 71.28, 16.96% vs. 70.77 and 21.61%), and the forward-moving sperm rate (41.47% 17.79% vs. 58.28)15 were in the CTM group, the LTM group, and the non-TM group. The differences were statistically significant (F = 10.522, 6.789, 4.540, 3.994, 4.797, 4.536; P = 0.000, 0.002, 0.016) for six aspects of the non-active sperm rate (11.90, 5.63% vs. 13.00, 3.71% vs. 18.10 and 7.27%) and the non-active sperm rate (46.63% 21.43% vs. 28.72, 16.96% vs. 29.25% 21.60%). (0.025, 0.013, 0.016).5. In the CTM group and non-TM group, the sperm concentration (44.89-26.14-106/ ml vs. 89.06-36.03-106/ ml), total sperm count (160.33-106.50-106 vs. 309.92-123.15-106), total sperm motility (53.37%) The difference was statistically significant (P = 0.000, 0.0, 21.43% vs. 70.77% 21.61), non-anterior exercise sperm rate (11.90% 5.63% vs. 18.10% 7.27%) and non-active sperm rate (46.63% 21.43% vs. 29.25% 21.60%), etc. 1, 0.021, 0.003, 0.021).6. At the same time, the difference between the LTM group and the non-TM group in the sperm concentration (60.06-20.16-106/ ml vs. 89.06-36.03-106/ ml) and the non-anterior exercise sperm rate (13.00-3.71% vs. 18.10-7.27%) was poor In addition, the total sperm count (160.33-106.50-106 vs. 253.05-165.74-106), total sperm motility (53.37-21.43% vs. 71.28-16.96%), total sperm motility (41.47-17.79% vs. 58.28-15.73%) and non-active sperm-rate (46.63-21.43) in the total number of sperm (160.33-106.50-106 vs. 253.05-165.74-106), total sperm motility (53.37-21.43% vs. 71.28-16.96%), total sperm motility (41.47-17.79% vs. 58.28-15.73%), and non-active sperm-rate (46.63-21.43 The difference was statistically significant (P <0.01). = 0 .043, 0.021, 0.013, 0.021 Conclusion 1. The testicular microlithiasis can affect the sperm quality of adult male. The relative ratio of microlithiasis in the pill is more significant than that of typical testicular microlithiasis on the quality of adult male sperm.3. Microlithiasis in the testis and adult male
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R697.22
本文編號(hào)：2487182
[Abstract]:Background and purpose of the study Testicular microlithiasis (TM) is a rare disease of male reproductive system in the clinic. It is characterized by the diffusion of multiple point-like calcium in the essence of the testis. In clinical work, the microlithiasis of the testis can be divided into two different types of diseases, namely, restricted testicular microlithiasis (LTM) and classic testicle microlithiasis (CTM). ). The current study has gradually reached a total of a gradual increase in the incidence of TM At present, most of the researchers are inclined to regard the TM as a reproductive system that is relevant to the male's spermatogenic function and has a clinical significance. The relationship between the specific causes of the TM, including its two different types (CTM and LTM), the pathogenesis, and the like, in particular the male fertility function, has led to the weight of many researchers and clinicians Therefore, the study of the relationship between testicular microlithiasis and its different types (CTM/ LTM) and the quality of adult male sperm is a very important and clinically meaningful study to analyze its correlation and whether there is a difference between different types I can provide some help for the implementation of diagnosis and treatment decision in the future clinical work. Co., Ltd. Materials and Methods 1. Retrospective analysis of 41 cases of testicular microlithiasis diagnosed by an ultrasonic examination, and the semen was routinely examined for adult male patients (i.e., TM) of the sperm. The clinical data of all 41 patients were divided into typical testicular microlithiasis (CTM) and constrained testicular microlithiasis (L (TM) two groups.2. A further collection of 11 adult male (i.e., non-TM) male (i.e., non-TM) who were not accompanied by testicular microlithiasis and were routinely examined for semen were also collected. 3. The data of the bed was analyzed.3. The statistical analysis was carried out by using the SPSS18.0 statistical software. The two of the two groups of independent samples were tested by Student's t. The comparison between the number of independent samples and the number of independent samples was one-Way ANOVA. to be poor Results 1. In total of 41 patients with TM,31 (75.61%) of the total 41 patients were diagnosed as CTM and 10 other patients (24 The mean age of the (39%) patients was 29.49 to 4.97 years and the mean body mass index (BMI) was 25.39 to 4.07 kg/ m2 and the mean testis The volume was 16.94 to 3.59 ml. The mean age of the CTM group was 30.06 to 5.28 years, the mean BMI was 25.54 to 4.33 kg/ m2, the mean testis volume was 16.66 to 3.39 ml, and the mean age of the LTM group was 27.70 to 3.47 years, with an average BMI of 24.92 and 3.27 kg/ m2, with an average testis The mean age of the non-TM group was 27.82-3.34 years, the mean BMI was 25.46-3.57 kg/ m2, and the average testis The total sperm concentration (48.59, 25.44,106/ ml vs. 89.06-36.03-106/ ml), the total number of sperm (182.95% 127.72-106 vs. 309.92-123.15-106) and the non-anterior exercise sperm rate (12.17% 5.21% vs. 18.10% 7.27%) were statistically significant (P = 0 The sperm concentration (44.89, 26.14,106/ ml vs. 60.06, 20.16,106/ ml vs. 89.06, 36.03,106/ ml), total sperm count (160.33, 106.50,106 vs. 253.05, 165.74,106 vs. 309.92, 16.96% vs. 70.77 and 21.61% vs. 71.28, 16.96% vs. 70.77 and 21.61%), and the forward-moving sperm rate (41.47% 17.79% vs. 58.28)15 were in the CTM group, the LTM group, and the non-TM group. The differences were statistically significant (F = 10.522, 6.789, 4.540, 3.994, 4.797, 4.536; P = 0.000, 0.002, 0.016) for six aspects of the non-active sperm rate (11.90, 5.63% vs. 13.00, 3.71% vs. 18.10 and 7.27%) and the non-active sperm rate (46.63% 21.43% vs. 28.72, 16.96% vs. 29.25% 21.60%). (0.025, 0.013, 0.016).5. In the CTM group and non-TM group, the sperm concentration (44.89-26.14-106/ ml vs. 89.06-36.03-106/ ml), total sperm count (160.33-106.50-106 vs. 309.92-123.15-106), total sperm motility (53.37%) The difference was statistically significant (P = 0.000, 0.0, 21.43% vs. 70.77% 21.61), non-anterior exercise sperm rate (11.90% 5.63% vs. 18.10% 7.27%) and non-active sperm rate (46.63% 21.43% vs. 29.25% 21.60%), etc. 1, 0.021, 0.003, 0.021).6. At the same time, the difference between the LTM group and the non-TM group in the sperm concentration (60.06-20.16-106/ ml vs. 89.06-36.03-106/ ml) and the non-anterior exercise sperm rate (13.00-3.71% vs. 18.10-7.27%) was poor In addition, the total sperm count (160.33-106.50-106 vs. 253.05-165.74-106), total sperm motility (53.37-21.43% vs. 71.28-16.96%), total sperm motility (41.47-17.79% vs. 58.28-15.73%) and non-active sperm-rate (46.63-21.43) in the total number of sperm (160.33-106.50-106 vs. 253.05-165.74-106), total sperm motility (53.37-21.43% vs. 71.28-16.96%), total sperm motility (41.47-17.79% vs. 58.28-15.73%), and non-active sperm-rate (46.63-21.43 The difference was statistically significant (P <0.01). = 0 .043, 0.021, 0.013, 0.021 Conclusion 1. The testicular microlithiasis can affect the sperm quality of adult male. The relative ratio of microlithiasis in the pill is more significant than that of typical testicular microlithiasis on the quality of adult male sperm.3. Microlithiasis in the testis and adult male
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R697.22
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