【摘要】：目的探討腎臟原發(fā)性神經(jīng)內(nèi)分泌腫瘤(primary renal neuroendocrine tumors,PRNET)的臨床病理學(xué)特征。方法對(duì)4例PRNET切除標(biāo)本行HE染色、免疫組化染色,電鏡下觀察其形態(tài)結(jié)構(gòu)、免疫表型及超微結(jié)構(gòu)特點(diǎn),并復(fù)習(xí)相關(guān)文獻(xiàn)。結(jié)果4例PRNET中3例男性,1例女性;年齡39~73歲,平均50歲。2例PRNET因腰背部疼痛就診,2例PRNET患者體檢發(fā)現(xiàn)入院。4例PRNET鏡下結(jié)構(gòu)相似,腫瘤細(xì)胞呈管狀、條帶狀緊密排列生長(zhǎng),部分呈巢、團(tuán)狀;腫瘤細(xì)胞規(guī)則一致,核深染,染色質(zhì)細(xì)膩,核仁不易見(jiàn),核分裂象均㩳3個(gè)/10 HPF。免疫表型:4例Syn均呈強(qiáng)陽(yáng)性,2例Cg A呈陽(yáng)性,2例CKpan呈局灶陽(yáng)性,1例P504S呈陽(yáng)性;CD10、CD117、PAX2、PAX8、PLAP、Ksp-cadherin均陰性;Ki-67增殖指數(shù)1%~5%。1例PRNET于電鏡下見(jiàn)胞質(zhì)內(nèi)有大量神經(jīng)內(nèi)分泌顆粒,細(xì)胞間有橋粒連接。結(jié)論 PRNET是一種罕見(jiàn)的腎臟腫瘤,可發(fā)生于腎臟任何部位,無(wú)明顯性別差異。診斷多依靠病理學(xué)檢查,并結(jié)合免疫表型,必要時(shí)輔助電鏡技術(shù)以明確診斷。
[Abstract]:Objective to investigate the clinicopathological features of primary renal neuroendocrine tumor (primary renal neuroendocrine tumors,PRNET. Methods HE staining, immunohistochemical staining and electron microscope were performed in 4 cases of PRNET resected specimens. The morphological structure, immunophenotypic and ultrastructure characteristics were observed under electron microscope, and the related literatures were reviewed. Results among the 4 cases of PRNET, 3 cases were male and 1 case was female. The age was 39 鈮，

本文編號(hào)：2479916