發(fā)布時間：2019-05-13 12:54

【摘要】：目的研究外源性抑炎因子生長激素釋放多肽-2(GHRP-2)對膿毒性急性腎損傷(AKI)的干預作用。方法選取SD大鼠80只,以�；悄懰徕c胰膽管注射法建立重癥急性胰腺炎(SAP)大鼠為膿毒癥模型,將大鼠隨機分為2組各40只,分別為對照組和干預組。對照組腹腔內(nèi)注射生理鹽水,干預組腹腔內(nèi)注射GHRP-2。觀察兩組大鼠血清肌酐(Cr)、尿素氮(BUN)以及腎組織丙二醛(MDA)和超氧化物歧化酶(SOD)水平變化。結果給藥后0 h兩組大鼠血清Cr、BUN水平及腎組織MDA、SOD水平差異均無統(tǒng)計學意義(P0.05);給藥后6、12及24 h干預組大鼠血清Cr、BUN水平明顯低于對照組(P0.05),腎組織MDA水平低于對照組(P0.05),腎組織SOD水平高于對照組(P0.05)。結論 GHRP-2對膿毒性AKI大鼠可降低血清Cr、BUN水平,增強腎組織SOD活性,降低腎組織MDA水平,對腎臟具有保護作用。
[Abstract]:Objective to study the intervention effect of exogenous anti-inflammatory factor growth hormone releasing polypeptide-2 (GHRP-2) on (AKI) in septic acute renal injury. Methods 80 SD rats were randomly divided into two groups: control group (n = 40) and intervention group (n = 40). The sepsis model of (SAP) rats with severe acute pancreatitis was established by injecting sodium taurocholate into pancreatic duct. Normal saline was injected into the abdominal cavity of the control group and GHRP-2. was injected intraperitoneally in the intervention group. The changes of serum creatinine (Cr), urea nitrogen (BUN), malondialdehyde (MDA) (MDA) and SOD (SOD) levels in renal tissue were observed in the two groups. Results there was no significant difference in serum Cr,BUN level and MDA,SOD level in renal tissue between the two groups at 0 h after administration (P 0.05). At 6 h, 12 h and 24 h after administration, the serum Cr,BUN level in the intervention group was significantly lower than that in the control group (P 0.05), the MDA level in renal tissue was lower than that in the control group (P 0.05), and the SOD level in renal tissue was higher than that in the control group (P 0.05). Conclusion GHRP-2 can decrease the level of serum Cr,BUN, enhance the activity of SOD in renal tissue and decrease the level of MDA in renal tissue of septic AKI rats. It has protective effect on kidney.
【作者單位】： 廣州市南沙中心醫(yī)院腎內(nèi)科;廣州市第一人民醫(yī)院腎內(nèi)科;
【基金】：廣州市衛(wèi)生和計劃生育委員會醫(yī)藥衛(wèi)生科技一般引導項目(編號:20151A010022)
【分類號】：R459.7;R692.5

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