【摘要】：研究目的 探討尿道狹窄冷刀內(nèi)切開術(shù)后尿道粘膜愈合的影響因素，為臨床治療尿道狹窄提供一定的依據(jù)。 研究對象和方法 回顧性分析2009年至2011年鄭州大學(xué)第一附屬醫(yī)院泌尿外科后尿道狹窄住院患者30例，所有患者均為男性，術(shù)前均行順行尿道造影和逆行尿道造影以確定尿道狹窄段長度，均行尿道狹窄冷刀內(nèi)切開術(shù)，術(shù)后1月采用導(dǎo)尿管周圍造影、尿道鏡觀察尿道狹窄處愈合情況、測尿流率三種方法，評估尿管留置時間對尿道粘膜愈合情況的影響。 結(jié)果 25例(83.3%)導(dǎo)尿管留置時間在12周以上，4例（13.3%）導(dǎo)尿管留置時間在8周以內(nèi)，1例（3.3%）失敗行2次手術(shù)治療，留置時間最短者4周，，最長者20周。以尿流率≥15ml"s為標(biāo)準(zhǔn)，1例于4周后尿流率≥15ml"s；4例于8周后≥15ml"s；24例于12周后≥15ml"s；27例于16周后≥15ml"s；29例于20周后≥15ml"s，差異具有統(tǒng)計學(xué)意義（P＜0.001）。隨訪24個月，排尿正常者20例（66.7%），尿流率均≥15ml"s；排尿基本正常者9例（30%），需半年擴尿道一次；1例（3.3%）拔除導(dǎo)尿管后再次形成狹窄，2次行手術(shù)治療后失訪。 結(jié)論 1導(dǎo)尿管留置時間和尿道愈合、療效呈正相關(guān)關(guān)系 2在積極的控制感染和加強營養(yǎng)的情況下，尿道狹窄冷刀內(nèi)切開術(shù)后拔除導(dǎo)尿管的最佳時間為8~12周左右。而導(dǎo)尿管周圍尿道造影、尿道鏡檢查、尿流率的測定可為導(dǎo)尿管的拔除提供可靠依據(jù)。
[Abstract]:Objective to investigate the influencing factors of urethral mucosa healing after cold knife incision for urethral stricture and to provide some evidence for clinical treatment of urethral stricture. Participants and methods A retrospective analysis of 30 inpatients with posterior urethral stricture in the first affiliated Hospital of Zhengzhou University from 2009 to 2011 was carried out, all of which were male. The length of urethral stricture was determined by antegrade urethrography and retrograde urethrography before operation. The length of urethral stricture was determined by cold knife internal incision. One month after operation, urethrography was used to observe the healing of urethral stricture, and the healing of urethral stricture was observed by urethroscopy. Three methods were used to evaluate the effect of indwelling time of catheter on the healing of urethra mucosa. Results 25 cases (83.3%) had catheter indwelling time more than 12 weeks, 4 cases (13.3%) had catheter indwelling time less than 8 weeks, 1 case (3.3%) failed to receive twice operation, and the shortest indwelling time was 4 weeks. A maximum of 20 weeks. According to the criteria of urinary flow rate 鈮

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