【摘要】：目的：采用系統(tǒng)評價方法評估中性粒細胞明膠酶相關(guān)脂質(zhì)運載蛋白（NGAL）在急性腎損傷早期的臨床診斷價值。 方法：計算機電子檢索Pubmed、Cochrane、EMBASE、CNKI、萬方、維普等數(shù)據(jù)庫中與NGAL相關(guān)的文獻，根據(jù)納入排除標準篩選文獻，，提取納入研究特征數(shù)據(jù)。采用QUADAS 2質(zhì)量評價工具進行納入研究的文獻質(zhì)量評價。利用Meta Disc1.4軟件，根據(jù)異質(zhì)性特點選擇相應(yīng)模型，進行診斷統(tǒng)計量合并。 結(jié)果：初篩到5511篇文獻，嚴格根據(jù)納入排除標準，最終納入35篇文獻，共納入研究對象8941例，其中AKI組患者2210例。Meta分析結(jié)果顯示尿NGAL與血NGAL的合并敏感度、特異度、綜合受試者工作特征曲線下面積分別為0.73（95%CI:0.71 0.76）、0.73（95%CI:0.72 0.74）、0.8658（SE:0.0201）以及0.80（95%CI:0.77 0.83）、0.76（95%CI:0.74 0.78）、0.8977（SE:0.0214）。 結(jié)論：血、尿NGAL對于患者AKI的發(fā)生預(yù)測，有較好的敏感度和特異度，對患者AKI的早期診斷有重要意義。
[Abstract]:Objective: to evaluate the clinical value of neutrophil gelatinase-associated lipid carrier protein (NGAL) in the early stage of acute renal injury. Methods: the literatures related to NGAL in Pubmed,Cochrane,EMBASE,CNKI, Wanfang and Weip databases were searched by computer, and the data were extracted according to the inclusion exclusion criteria. The literature quality was evaluated by QUADAS 2 quality evaluation tool. By using Meta / Disc1.4 software, the corresponding models were selected according to the characteristics of heterogeneity, and the diagnostic statistics were merged. Results: from the first screening to 5511 articles, strictly according to the exclusion criteria, 35 articles were included in the study. A total of 8941 subjects were included in the study, including 2210 patients in the AKI group. The results of Meta analysis showed the combined sensitivity and specificity of urinary NGAL and blood NGAL. The area under the operating characteristic curve was 0.73 (95%CI:0.71 0.76), 0.73 (95%CI:0.72 0.74), 0.8658 (SE:0.0201) and 0.80 (95%CI:0.77 0.83), respectively. 0.76 (95%CI:0.74 0.78), 0.8977 (SE:0.0214). Conclusion: NGAL in blood and urine has good sensitivity and specificity in predicting the occurrence of AKI in patients. It is important for the early diagnosis of AKI in patients.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R692

【參考文獻】

相關(guān)期刊論文 前6條

1 陳玉;王艷琴;蔡利勵;鄭劍鋒;王小中;;尿Netrin-1與NGAL聯(lián)合檢測在成人體外循環(huán)術(shù)后急性腎損傷早期診斷中的意義[J];實驗與檢驗醫(yī)學;2013年04期

2 趙京生;吳鐵軍;易偉國;李爭;湯服民;熊健;羅運成;;檢測中性粒細胞明膠酶脂質(zhì)運載蛋白早期診斷體外循環(huán)術(shù)后急性腎損傷[J];實用醫(yī)藥雜志;2011年01期

3 蔡雷鳴;厲倩;金才峰;譚龍益;廖敏蕾;鮑潔;;血清中性粒細胞明膠酶相關(guān)脂質(zhì)運載蛋白檢測在急性腎功能損傷早期診斷中的臨床意義[J];檢驗醫(yī)學;2012年04期

4 姜琦;朱波;姜利;李春陽;蔣波;王美平;;血中性粒細胞明膠酶相關(guān)脂質(zhì)運載蛋白對ICU中急性腎損傷的早期診斷價值[J];臨床和實驗醫(yī)學雜志;2012年11期

5 楊志棟;;NAG、KIM-1、NGAL在創(chuàng)傷后急性腎損傷中的診斷價值[J];中國衛(wèi)生檢驗雜志;2013年08期

6 黃寶磚;李越華;卜建宏;邱為;;尿N-乙酰-β-D-氨基葡萄糖苷酶與尿肌酐比在老年重癥肺炎合并急性腎損傷患者中的診斷意義[J];中國血液凈化;2010年06期

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