【摘要】：目的：系統(tǒng)分析中藥、中西藥聯(lián)合治療男性少弱精子癥的療效,以期對中藥、中西藥聯(lián)合治療男性少弱精子癥的療效做出客觀、可信的評價,為男性少弱精子癥的臨床治療用藥治療提供有價值的參考。 方法：采用循證醫(yī)學(xué)的方法,全面檢索國內(nèi)2007年至2013年12月中醫(yī)藥治療男性少弱精子癥的臨床研究文獻(xiàn),按照文獻(xiàn)可靠性分級、Jadad量表等評價文獻(xiàn)的質(zhì)量,對符合納入標(biāo)準(zhǔn)的文獻(xiàn)進(jìn)行系統(tǒng)評價,部分文獻(xiàn)進(jìn)行Meta-分析。評因為各文獻(xiàn)側(cè)重評價指標(biāo)不盡相同,所以系統(tǒng)評價指標(biāo)包括有效率、精子密度、活動率等。其中所有的二分變量資料本系統(tǒng)評價均以相同方式來評價,即以比數(shù)比(OR)、相對危險度(RR)來評價；所有的連續(xù)變量資料則以另一種方式來評價,均以加權(quán)均數(shù)差(WMD)來評價。總體異質(zhì)性卡方檢驗p0.05采用固定效應(yīng)模型分析,反之采用隨機效應(yīng)模型分析。 結(jié)果：截止至2013年12月,符合檢索條件全部納入標(biāo)準(zhǔn)的文獻(xiàn)總共是有18篇,共2551例病人。本系統(tǒng)評價顯示,中藥、中西藥聯(lián)合對男性少弱精子癥的治療與西藥相比,在提高臨床有效率方面有明顯的優(yōu)勢,同時數(shù)據(jù)也明確表示出了藥物不良反應(yīng)的發(fā)生的概率也相對比較低。由于實驗側(cè)重點不同,男性激素水平方面的數(shù)據(jù)極少涉及。但是,由于各種誤差的存在,尚不能完全排除例如發(fā)表偏倚等相關(guān)因素對結(jié)果的影響。 結(jié)論：中藥、中西藥聯(lián)合對男性少弱精子癥的治療與西藥相比,有更好的臨床療效,同時不良反應(yīng)的發(fā)生率也較低。但是,由于各種誤差的存在,尚不能完全排除例如發(fā)表偏倚等相關(guān)因素對結(jié)果的影響。這些因素?zé)o可避免的引起了這篇系統(tǒng)評價在臨床價值方面略微降低。
[Abstract]:Objective: to analyze the efficacy of Chinese medicine and western medicine in the treatment of male oligozoospermia, in order to make an objective and credible evaluation on the efficacy of Chinese medicine and western medicine in the treatment of male oligozoospermia. To provide a valuable reference for the treatment of male oligozoospermia. Methods: Evidence-based medicine (EBM) was used to search the literature on the treatment of oligozoospermia in China from 2007 to December 2013. The quality of the literature was evaluated according to the reliability classification and Jadad scale. A systematic review of the literature that meets the inclusion criteria is carried out, and some of the documents are analyzed by Meta-. Because the evaluation indexes are not the same, the systematic evaluation indexes include efficiency, sperm density, motility rate and so on. All the binary variables were evaluated in the same way, that is, the relative risk of (OR), was evaluated by (RR). All the data of continuous variables are evaluated in another way, which is evaluated by weighted mean difference (WMD). The global heterogeneity chi-square test p0.05 uses fixed effect model analysis, whereas uses random effect model analysis. Results: as of December 2013, there were 18 articles (2551 patients) that met the criteria for retrieval. The systematic evaluation shows that the treatment of male oligozoospermia with traditional Chinese medicine and western medicine has obvious advantages in improving the clinical effective rate compared with western medicine. The data also show that the probability of adverse drug reactions is relatively low. Data on male hormone levels are rarely available because of the different focus of the experiment. However, due to the existence of various errors, the influence of related factors, such as publication bias, on the results cannot be completely excluded. Conclusion: the treatment of oligozoospermia with traditional Chinese medicine and western medicine is better than that of western medicine, and the incidence of adverse reactions is lower. However, due to the existence of various errors, the influence of related factors, such as publication bias, on the results cannot be completely excluded. These factors inevitably led to a slight decline in the clinical value of this systematic review.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R698.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張樹成,孟小波,劉彬,賀斌,楚林鋼,王弘毅,史延超,王介東;不同人群精液質(zhì)量現(xiàn)狀的分析[J];Developmental & Reproductive Biology;2002年02期

2 李大文;孟繁華;韓偉;王英俊;;自擬十子二仙湯合左卡尼汀治療腎陽虛型弱精子癥臨床觀察[J];廣西中醫(yī)學(xué)院學(xué)報;2010年03期

3 王紅全;裴鮮玲;張愛英;彭琳英;;益精補元湯治療少弱精子癥100例臨床觀察[J];河北中醫(yī);2010年10期

4 宋方聞;鐘惟德;;生精膠囊治療少弱精子癥的臨床療效觀察[J];中華男科學(xué)雜志;2009年08期

5 白雙勇;彭林;歐陽武;葉峻杰;李江川;;生精膠囊治療少弱精子癥療效觀察[J];中國男科學(xué)雜志;2007年12期

6 何學(xué)酉;李鋼;張旭;姜輝;趙連明;戴東曦;謝毅;;小劑量雄激素治療少弱精子癥的臨床研究[J];中國男科學(xué)雜志;2009年12期

7 張迅;梁季鴻;梁世坤;韋國強;朱春暉;申樹林;宋衛(wèi)儒;李廣裕;;復(fù)方玄駒膠囊聯(lián)合他莫西芬治療特發(fā)性少精子癥的臨床研究[J];中華男科學(xué)雜志;2012年07期

8 王慶;寧克勤;黃新飛;;自擬益精湯治療少弱精子癥的療效觀察[J];遼寧中醫(yī)雜志;2012年10期

9 張敬然;姚莎;;龍馬育嗣湯治療少弱精子癥臨床觀察[J];河北中醫(yī);2012年12期

10 黎杰運;尹霖;周文彬;洪志明;李時光;程波敏;;自擬生精贊育方治療少弱精子癥80例[J];遼寧中醫(yī)雜志;2013年06期

相關(guān)碩士學(xué)位論文 前1條

1 李博;中醫(yī)藥治療阿片類戒斷綜合征的系統(tǒng)評價及臨床調(diào)研[D];北京中醫(yī)藥大學(xué);2006年

，

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