【摘要】：目的：系統(tǒng)分析中藥、中西藥聯(lián)合治療男性少弱精子癥的療效,以期對(duì)中藥、中西藥聯(lián)合治療男性少弱精子癥的療效做出客觀、可信的評(píng)價(jià),為男性少弱精子癥的臨床治療用藥治療提供有價(jià)值的參考。 方法：采用循證醫(yī)學(xué)的方法,全面檢索國(guó)內(nèi)2007年至2013年12月中醫(yī)藥治療男性少弱精子癥的臨床研究文獻(xiàn),按照文獻(xiàn)可靠性分級(jí)、Jadad量表等評(píng)價(jià)文獻(xiàn)的質(zhì)量,對(duì)符合納入標(biāo)準(zhǔn)的文獻(xiàn)進(jìn)行系統(tǒng)評(píng)價(jià),部分文獻(xiàn)進(jìn)行Meta-分析。評(píng)因?yàn)楦魑墨I(xiàn)側(cè)重評(píng)價(jià)指標(biāo)不盡相同,所以系統(tǒng)評(píng)價(jià)指標(biāo)包括有效率、精子密度、活動(dòng)率等。其中所有的二分變量資料本系統(tǒng)評(píng)價(jià)均以相同方式來(lái)評(píng)價(jià),即以比數(shù)比(OR)、相對(duì)危險(xiǎn)度(RR)來(lái)評(píng)價(jià)；所有的連續(xù)變量資料則以另一種方式來(lái)評(píng)價(jià),均以加權(quán)均數(shù)差(WMD)來(lái)評(píng)價(jià)。總體異質(zhì)性卡方檢驗(yàn)p0.05采用固定效應(yīng)模型分析,反之采用隨機(jī)效應(yīng)模型分析。 結(jié)果：截止至2013年12月,符合檢索條件全部納入標(biāo)準(zhǔn)的文獻(xiàn)總共是有18篇,共2551例病人。本系統(tǒng)評(píng)價(jià)顯示,中藥、中西藥聯(lián)合對(duì)男性少弱精子癥的治療與西藥相比,在提高臨床有效率方面有明顯的優(yōu)勢(shì),同時(shí)數(shù)據(jù)也明確表示出了藥物不良反應(yīng)的發(fā)生的概率也相對(duì)比較低。由于實(shí)驗(yàn)側(cè)重點(diǎn)不同,男性激素水平方面的數(shù)據(jù)極少涉及。但是,由于各種誤差的存在,尚不能完全排除例如發(fā)表偏倚等相關(guān)因素對(duì)結(jié)果的影響。 結(jié)論：中藥、中西藥聯(lián)合對(duì)男性少弱精子癥的治療與西藥相比,有更好的臨床療效,同時(shí)不良反應(yīng)的發(fā)生率也較低。但是,由于各種誤差的存在,尚不能完全排除例如發(fā)表偏倚等相關(guān)因素對(duì)結(jié)果的影響。這些因素?zé)o可避免的引起了這篇系統(tǒng)評(píng)價(jià)在臨床價(jià)值方面略微降低。
[Abstract]:Objective: to analyze the efficacy of Chinese medicine and western medicine in the treatment of male oligozoospermia, in order to make an objective and credible evaluation on the efficacy of Chinese medicine and western medicine in the treatment of male oligozoospermia. To provide a valuable reference for the treatment of male oligozoospermia. Methods: Evidence-based medicine (EBM) was used to search the literature on the treatment of oligozoospermia in China from 2007 to December 2013. The quality of the literature was evaluated according to the reliability classification and Jadad scale. A systematic review of the literature that meets the inclusion criteria is carried out, and some of the documents are analyzed by Meta-. Because the evaluation indexes are not the same, the systematic evaluation indexes include efficiency, sperm density, motility rate and so on. All the binary variables were evaluated in the same way, that is, the relative risk of (OR), was evaluated by (RR). All the data of continuous variables are evaluated in another way, which is evaluated by weighted mean difference (WMD). The global heterogeneity chi-square test p0.05 uses fixed effect model analysis, whereas uses random effect model analysis. Results: as of December 2013, there were 18 articles (2551 patients) that met the criteria for retrieval. The systematic evaluation shows that the treatment of male oligozoospermia with traditional Chinese medicine and western medicine has obvious advantages in improving the clinical effective rate compared with western medicine. The data also show that the probability of adverse drug reactions is relatively low. Data on male hormone levels are rarely available because of the different focus of the experiment. However, due to the existence of various errors, the influence of related factors, such as publication bias, on the results cannot be completely excluded. Conclusion: the treatment of oligozoospermia with traditional Chinese medicine and western medicine is better than that of western medicine, and the incidence of adverse reactions is lower. However, due to the existence of various errors, the influence of related factors, such as publication bias, on the results cannot be completely excluded. These factors inevitably led to a slight decline in the clinical value of this systematic review.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R698.2

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