【摘要】：目的：比較浸潤(rùn)性膀胱癌術(shù)中放療，和傳統(tǒng)的膀胱部分切除術(shù)與根治性全膀胱切除術(shù)的臨床治療效果。 方法：回顧性分析114例原發(fā)性浸潤(rùn)性膀胱癌患者的臨床資料，并根據(jù)治療方式將其分為3組：部分切除組（A組，n=36），，術(shù)中放療組（B組，n=35），以及根治組（C組，n=43）。分別對(duì)B組與A組，B組與C組兩組患者的年齡，性別，腫瘤的臨床分期，病理分級(jí)，手術(shù)時(shí)間、術(shù)中出血量、住院天數(shù)、術(shù)后腫瘤復(fù)發(fā)情況以及五年生存率進(jìn)行統(tǒng)計(jì)分析。采用SPSS19.0統(tǒng)計(jì)軟件進(jìn)行處理，計(jì)量資料采用均數(shù)±標(biāo)準(zhǔn)差表示，計(jì)量資料采取t檢驗(yàn)，計(jì)數(shù)資料采取X2檢驗(yàn)，以P0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果：3組手術(shù)均成功完成。在A組與B組比較中，在性別、年齡、臨床分期、病理分級(jí)、術(shù)中出血量，住院天數(shù)方面，差異無統(tǒng)計(jì)學(xué)意義（P0.05），在手術(shù)時(shí)間，腫瘤復(fù)發(fā)及五年生存率方面，差異有統(tǒng)計(jì)學(xué)意義（P0.05）；在C組與B組中，在性別、年齡、臨床分期、病理分級(jí)、腫瘤復(fù)發(fā)及五年生存率方面，差異無統(tǒng)計(jì)學(xué)意義（P0.05），在手術(shù)時(shí)間，術(shù)中出血量，住院天數(shù)方面，差異有統(tǒng)計(jì)學(xué)意義（P0.05）。 結(jié)論：本實(shí)驗(yàn)術(shù)中放療組治療浸潤(rùn)性膀胱癌的腫瘤復(fù)發(fā)率及五年生存率均與根治組相近，明顯優(yōu)于膀胱部分切除組，而手術(shù)創(chuàng)傷及術(shù)后恢復(fù)情況卻與膀胱部分切除術(shù)相似，是浸潤(rùn)性膀胱癌是除根治術(shù)外又一項(xiàng)可行的治療方式。
[Abstract]:Objective: to compare the clinical effects of intraoperative radiotherapy for invasive bladder cancer and traditional partial cystectomy and radical total cystectomy. Methods: the clinical data of 114 patients with primary invasive bladder cancer were retrospectively analyzed and divided into 3 groups according to the treatment methods: partial resection group (group A, n = 36), intraoperative radiotherapy group (group B, n = 35) and radical resection group (group C, n = 43). The age, sex, clinical stage, pathological grade, operative time, intraoperative bleeding volume, hospital stay, recurrence of tumor and 5-year survival rate were statistically analyzed in group B and group A, group B and group C respectively. SPSS19.0 statistical software was used to process the measurement data with mean 鹵standard deviation, measurement data with t test, count data with X2 test, with P0.05 as the difference was statistically significant. Results: all the 3 groups were successfully completed. There was no significant difference between group A and group B in sex, age, clinical stage, pathological grade, intraoperative bleeding volume and length of hospitalization (P0.05), but there was no significant difference in operative time, tumor recurrence and 5-year survival rate. The difference was statistically significant (P0.05). In group C and group B, there was no significant difference in sex, age, clinical stage, pathological grade, tumor recurrence and 5-year survival rate (P0.05). The difference was statistically significant (P0.05). Conclusion: the tumor recurrence rate and 5-year survival rate in the intraoperative radiotherapy group were similar to those in the radical resection group, and were significantly superior to those in the partial cystectomy group, but the surgical trauma and postoperative recovery were similar to those in the cystectomy group. Invasive bladder cancer is a feasible treatment in addition to radical resection.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R737.14

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