【摘要】：目的探討P504s及特異AT序列結(jié)合蛋白1(SATB1)基因在前列腺癌的表達(dá),及其在前列腺癌發(fā)生、發(fā)展中的作用。方法應(yīng)用免疫組織化學(xué)染色檢測P504s及SATB1蛋白在60例前列腺癌和30例前列腺增生癥組織中的表達(dá)。結(jié)果 SATB1在前列腺癌組織中的表達(dá)陽性率(78.3%)較前列腺增生組織(0.0%)明顯升高,差異有統(tǒng)計(jì)學(xué)意義(P0.05),SATB1的表達(dá)隨著Gleason評分增加而升高(P0.05)。P504s在前列腺癌組織中的陽性表達(dá)率(95.0%)遠(yuǎn)高于前列腺增生癥組(0.0%)(P0.05),但其在前列腺癌中的表達(dá)不會隨著Gleason評分增加而升高(P0.05)。結(jié)論 P504s和SATB1在前列腺癌中的高表達(dá),結(jié)合形態(tài)學(xué)綜合分析,可能有助于提高前列腺癌的診斷及鑒別診斷,而SATB1蛋白在前列腺癌組織中的異常表達(dá),提示可能與前列腺癌的發(fā)生、發(fā)展有關(guān)。
[Abstract]:Objective to investigate the expression of P504s and specific AT sequence-binding protein 1 (SATB1) gene in prostate cancer and its role in the pathogenesis and development of prostate cancer. Methods Immunohistochemical staining was used to detect the expression of P504s and SATB1 protein in 60 cases of prostate cancer and 30 cases of prostatic hyperplasia. Results the positive rate of SATB1 in prostate cancer tissues (78.3%) was significantly higher than that in prostatic hyperplasia tissues (0.00%), and the difference was statistically significant (P0.05). The expression of SATB1 increased with the increase of Gleason score (P0.05). The positive expression rate of P504s in prostate cancer (95.0%) was much higher than that in benign prostatic hyperplasia (0.00%) (P0.05). However, its expression in prostate cancer did not increase with the increase of Gleason score (P0.05). Conclusion the high expression of P504s and SATB1 in prostate cancer may be helpful to improve the diagnosis and differential diagnosis of prostate cancer, and the abnormal expression of SATB1 protein in prostate cancer may be associated with the occurrence of prostate cancer. Development is relevant.
【作者單位】： 遼寧醫(yī)學(xué)院病理學(xué)教研室;
【分類號】：R737.25

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本文編號：2299805