【摘要】：目的探討X射線修復(fù)交叉互補(bǔ)基因3(XRCC3)rs861539(CT)多態(tài)性與膀胱癌易感性的關(guān)系。方法用聚合酶鏈反應(yīng)-限制性片段長(zhǎng)度多態(tài)性方法檢測(cè)201例膀胱癌患者(病例組)及200例年齡、性別相匹配的健康人(對(duì)照組)XRCC3 rs861539(CT)的基因型,比較各基因型與膀胱癌發(fā)病風(fēng)險(xiǎn)以及膀胱癌病理分期、分級(jí)的關(guān)系,同時(shí)分層分析其與吸煙的關(guān)系。結(jié)果病例組XRCC3 rs861539位點(diǎn)CC、CT、TT 3種基因型分布頻率分別為85.6%、13.9%、0.5%,對(duì)照組分別為93%、6.5%、0.5%,兩組基因型頻率分布差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與基因型CC相比,攜帶突變等位基因T的基因型(CT+TT)發(fā)生膀胱癌的風(fēng)險(xiǎn)增加3.077倍(OR 95%CI:1.452~6.882,P0.05);XRCC3 rs861539基因型在吸煙及膀胱癌病理分期、分級(jí)之間的分布差異無統(tǒng)計(jì)學(xué)意義(P均0.05)。結(jié)論 XRCC3 rs861539多態(tài)性可能增加膀胱癌的發(fā)病風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the relationship between X-ray repair cross-complementary gene 3 (XRCC3) rs861539 (CT) polymorphism and bladder cancer susceptibility. Methods XRCC3 rs861539 (CT) genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 201 bladder cancer patients (case group) and 200 age-matched healthy subjects (control group). The relationship between genotypes and the risk of bladder cancer, the pathological stage and grade of bladder cancer was compared, and the relationship between genotype and smoking was analyzed by stratification. Results the frequencies of CC,CT,TT genotypes at XRCC3 rs861539 locus in the case group were 85.6 and 13.9g, respectively, and those in the control group were 936.5g and 0.5g, respectively. There was significant difference in the frequency distribution between the two groups (P0.05). Compared with genotype CC, the risk of bladder cancer in genotype (CT TT) with mutant allele T was increased 3.077 times (OR 95 CI: 1.452C6.882p0.05), and the distribution of XRCC3 rs861539 genotype in smoking, pathological stage and grade of bladder cancer had no significant difference (P0.05). Conclusion XRCC3 rs861539 polymorphism may increase the risk of bladder cancer.
【作者單位】： 廣西醫(yī)科大學(xué)第一附屬醫(yī)院;廣西醫(yī)科大學(xué)附屬腫瘤醫(yī)院;
【基金】：廣西壯族自治區(qū)教育廳科研資助項(xiàng)目(201012MS046)
【分類號(hào)】：R737.14
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本文編號(hào)：2266001