【摘要】：目的系統(tǒng)評價腹腔鏡腎部分切除術(LPN)與腹腔鏡冷凍消融術(LCA)治療小腎腫瘤(SRMs)的安全性及療效。方法計算機檢索Pub Med、SCI、Ovid、The Cochrane Library、CNKI、CBM、VIP及萬方數(shù)據庫,全面收集有關LPN與LCA比較治療SRMs的臨床對照試驗,檢索時限截至2016年4月。由2名評價者按照納入與排除標準選擇試驗、提取資料和評價質量后,采用Rev Man 5.3軟件進行Meta分析。結果納入9篇研究,共748例患者。Meta分析結果顯示:LCA較LPN手術時間短[均數(shù)差(MD)=42.75,95%CI(12.19,73.31),P=0.006],術中出血量少[MD=190.73,95%CI(126.67,254.78),P=0.000],住院時間短[MD=2.23,95%CI(0.17,4.28),P=0.030],術式轉換率低[比值比(OR)=3.54,95%CI(1.18,10.59),P=0.020],并發(fā)癥少[OR=3.90,95%CI(1.84,8.24),P=0.000],術后腎小球濾過率(GFR)下降量低[MD=10.30,95%CI(5.38,15.24),P=0.000],局部復發(fā)風險高[OR=0.13,95%CI(0.04,0.44),P=0.000],遠處轉移風險高[OR=0.16,95%CI(0.03,0.78),P=0.020],而在術后血肌酐(Scr)上升量、輸血率比較差異均無統(tǒng)計學意義(P0.05)。結論 LCA在圍手術期結果、保護腎功能方面更有優(yōu)勢,但其有較高的腫瘤局部復發(fā)和遠處轉移風險,近期、中期療效相當,遠期療效尚不明確,故在手術病例的選擇上仍需謹慎。
[Abstract]:Objective to evaluate the safety and efficacy of laparoscopic partial nephrectomy (LPN) and laparoscopic frozen ablation (LCA) in the treatment of small renal tumors. Methods to search the database of Pub Medtome, the Cochrane Library and the Wanfang database, and to collect the clinical controlled trials about the comparison of LPN and LCA in the treatment of SRMs. The retrieval time was up to April 2016. According to the inclusion and exclusion criteria, the two evaluators selected the test, extracted the data and evaluated the quality, and then carried out the Meta analysis with Rev Man 5.3 software. The results were included in 9 studies, 鍏，

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