【摘要】：自噬是一個基因編程、進化保守的過程，通過對過多的、有害的，或衰老的蛋白質(zhì)和細胞器進行降解，保持對重要細胞成分的控制，在正常生物體內(nèi)扮演著重要角色。研究發(fā)現(xiàn)，自噬與腫瘤關(guān)系密切，對腫瘤發(fā)生和發(fā)展起著重要作用。在前列腺癌細胞中，自噬的發(fā)生不僅對前列腺癌的進展轉(zhuǎn)移有著重要促進作用，而且還能通過保護前列腺癌細胞免受外界環(huán)境變化的影響，對治療前列腺癌的藥物產(chǎn)生抵抗。自噬可通過多種蛋白酶、細胞因子及基因包括腺苷酸活化蛋白酶、單核細胞趨化蛋白1、酪氨酸激酶、mda-7/IL-24及P21等的調(diào)控參與對前列腺癌產(chǎn)生影響，而運用異戊烯半胱氨酸羧甲基轉(zhuǎn)移酶抑制劑、非瑟酮、二甲雙胍與2脫氧葡萄糖等藥物來抑制自噬可誘導(dǎo)前列腺癌凋亡。因此，探討自噬在前列腺癌中的調(diào)控機理，開發(fā)相關(guān)的自噬抑制藥物，可為前列腺癌的治療提供新方法。
[Abstract]:Autophagy is a genetically programmed, evolutionarily conserved process that plays an important role in normal organisms by degrading excessive, harmful, or aging proteins and organelles and maintaining control over important cellular components. It has been found that autophagy is closely related to tumor and plays an important role in tumorigenesis and development. In prostate cancer cells autophagy not only plays an important role in promoting the progression and metastasis of prostate cancer but also can protect prostate cancer cells from the effects of environmental changes. Autophagy plays an important role in prostate cancer through the regulation of a variety of proteases, cytokines and genes, including adenylate activated protease, monocyte chemoattractant protein 1, tyrosine kinase mda-7 / IL-24 and P21, etc. Inhibition of autophagy by isopentene cysteine carboxymethyl transferase inhibitor, fenestrone, metformin and 2 deoxyglucose could induce apoptosis of prostate cancer. Therefore, to explore the regulatory mechanism of autophagy in prostate cancer and to develop related autophagy inhibitors may provide a new method for the treatment of prostate cancer.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R737.25

【參考文獻】

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1 Gy銉rgyi M，

本文編號：2143103