本文選題：CUEDC + CollagenⅠ　； 參考：《實(shí)用醫(yī)學(xué)雜志》2016年12期

【摘要】：目的:研究CUEDC2對(duì)單側(cè)輸尿管梗阻(UUO)小鼠腎組織炎癥反應(yīng)及間質(zhì)纖維化的作用。方法:Balb/c小鼠30只,隨機(jī)分為假手術(shù)組、UUO組和CUEDC2治療組。HE及Masson染色觀察腎臟病理改變;ELISA法檢測(cè)炎癥因子表達(dá);免疫組化法檢測(cè)腎組織CUEDC2表達(dá);Western Blot檢測(cè)CUEDC2、纖連蛋白(Fibronectin)、鈣黏蛋白(E-cadherin)、膠原蛋白I型(Collagen Ⅰ)表達(dá)。結(jié)果 :術(shù)后7、14 d,CUEDC2治療組的腎間質(zhì)纖維化相對(duì)面積、炎癥因子ICAM1、MCP1、IL-1、IL-8表達(dá)及Fibronectin、CollagenⅠ表達(dá)均較UUO組明顯減少(P0.05),E-cadherin表達(dá)明顯增加(P0.05)。結(jié)論:CUEDC2可以抑制多種炎癥因子表達(dá),減少間質(zhì)膠原沉積,減輕腎臟纖維化。
[Abstract]:Aim: to study the effect of CUEDC2 on renal inflammation and interstitial fibrosis in unilateral ureteral obstruction (UUO) mice. Methods Thirty male Balb / c mice were randomly divided into sham-operation group (UUO) group and CUEDC2 treatment group. He and Masson staining were used to detect the expression of inflammatory factors in the kidney. The expressions of CUEDC2, fibronectin, E-cadherin and collagen I in renal tissue were detected by Western blot. Results: the relative area of renal interstitial fibrosis, the expression of IL-8 and the expression of fibronectinine Collagen 鈪，

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