本文選題：超聲 + 常規(guī)超聲　； 參考：《吉林大學(xué)》2014年碩士論文

【摘要】：目的：應(yīng)用超聲剪切波技術(shù)檢測(cè)63例不同程度慢性腎臟疾病患者的腎臟皮質(zhì)，將檢測(cè)結(jié)果與患者臨床表現(xiàn)、疾病分期、腎功能檢驗(yàn)等資料進(jìn)行對(duì)照分析，進(jìn)一步探討超聲剪切波技術(shù)在慢性腎臟疾病的診斷及分期上的應(yīng)用價(jià)值，為超聲剪切波技術(shù)在腎臟疾病中的應(yīng)用研究積累資料。 方法：以2012年10月～2014年2月期間在我院腎病內(nèi)科就診及住院治療的63例患者及30例健康成人作為研究對(duì)象。慢性腎臟疾病診斷標(biāo)準(zhǔn)是：不論何種原因?qū)е碌哪I臟損害或者腎功能下降即腎小球率過濾（GFR）每1.73平方米＜60ml/min，并且持續(xù)三個(gè)月以上者。對(duì)所有研究對(duì)象的左腎進(jìn)行二維超聲、彩色多普勒超聲和超聲剪切波檢查。將研究對(duì)象的超聲檢查資料與實(shí)驗(yàn)室檢查資料進(jìn)行比較分析[8]。 結(jié)果：63例慢性腎臟疾病（CKD）患者分為CKD1期（16例）、CKD2期（13例）、CKD3期（11例）、CKD4期（10例）、CKD5期（13例）。超聲剪切波技術(shù)檢測(cè)VTQ值：CKD1期患者測(cè)值2.46±0.34；CKD2期患者測(cè)值2.30±0.48；CKD3期患者測(cè)值2.06±0.27；CKD4期患者測(cè)值1.86±0.52；CKD5期患者測(cè)值1.08±0.36；正常對(duì)照組測(cè)值3.04±0.23。 正常組VTQ值均＞CKD各期VTQ值，P＜0.001，差異有統(tǒng)計(jì)學(xué)意義；CKD1期VTQ值＞CKD3、CKD4、CKD5期VTQ值，P＜0.05，差異有統(tǒng)計(jì)學(xué)意義；。CKD5期VTQ值均＜CKD1、CKD2、CKD3、CKD4期VTQ值，P＜0.05，差異有統(tǒng)計(jì)學(xué)意義；CKD1期與CKD2期比較、CKD2期與CKD3期比較、CKD3期與CKD4期比較，VTQ值差異P＞0.05，無統(tǒng)計(jì)學(xué)意義。 結(jié)論：1.慢性腎臟疾病組超聲VTQ測(cè)值小于正常組。超聲VTQ技術(shù)對(duì)慢性腎臟疾病的診斷有臨床意義。將VTQ值≤2.67作為診斷慢性腎臟疾病的分界點(diǎn)，可為臨床診斷提供參考。2.超聲VTQ測(cè)值對(duì)診斷早期慢性腎臟疾病及對(duì)慢性腎臟疾病的分期診斷有一定的臨床應(yīng)用價(jià)值。3慢性腎臟疾病組腎臟VTQ測(cè)值與患者血清肌酐測(cè)值及尿素氮測(cè)值呈負(fù)性相關(guān)性，，根據(jù)VTQ測(cè)值判斷慢性腎臟疾病患者的腎功能有一定可行性。
[Abstract]:Objective: to detect the renal cortex of 63 patients with different degrees of chronic renal disease by using ultrasonic shear wave technique, and to compare the results with the clinical manifestations, disease stages, renal function test and so on. To further explore the application value of ultrasonic shear wave technique in the diagnosis and staging of chronic renal disease, and to accumulate data for the application of ultrasonic shear wave technique in kidney disease. Methods: from October 2012 to February 2014, 63 patients and 30 healthy adults were enrolled in the study. The diagnostic criteria for chronic renal disease were as follows: glomerular filtration (GFR) was less than 60 ml / min per 1.73 m2 and lasted for more than three months, regardless of the cause of renal damage or decline in renal function. The left kidney of all subjects were examined by two-dimensional ultrasound, color Doppler ultrasound and ultrasonic shear wave. The ultrasonic data of the subjects were compared with the laboratory data [8]. Results Sixty-three patients with chronic renal disease (CKD) were divided into CKD1 (16 cases), CKD2 (13 cases), CKD3 (11 cases), CKD4 (10 cases) and CKD5 (13 cases). The VTQ value was 2.46 鹵0.34 + CKD2 by ultrasonic shear wave technique, and the value was 2.06 鹵0.27CKD4 stage 1.86 鹵0.52 CKD5 stage and 3.04 鹵0.23 in normal control group. The VTQ value of normal group was higher than that of CKD in each stage (P < 0.001), and the difference was statistically significant (P < 0.05). The VTQ value of CKD1 stage was higher than that of CKD4CKD5 stage (P < 0.05), and the VTQ value of CKD5 phase was significantly lower than that of CKD1CKD2CKD3CKD3 CKD4 phase (P < 0.05). There was no significant difference in VTQ between CKD3 and CKD4 compared with CKD1 and CKD2 (P > 0.05). Conclusion 1. The value of VTQ in chronic renal disease group was lower than that in normal group. Ultrasonic VTQ technique has clinical significance in the diagnosis of chronic renal disease. Taking VTQ 鈮

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