本文選題：CKD5D + 氧化應(yīng)激�。� 參考：《上海交通大學(xué)》2014年碩士論文

【摘要】：目的：探討CKD5D期腎病患者體內(nèi)氧化應(yīng)激水平變化及相關(guān)影響因素，比較不同的腎替代治療方式對(duì)終末期腎病患者體內(nèi)氧化應(yīng)激水平的影響。 方法：收集CKD5D期患者血清，采用雙抗體夾心法測(cè)定血清超氧化物歧化酶（SOD）、丙二醛(MDA)和谷胱甘肽-過氧化物酶（GSH-Px）水平，同時(shí)收集患者臨床資料，用統(tǒng)計(jì)學(xué)方法進(jìn)行相關(guān)影響因素分析。 結(jié)果：CKD5D期患者氧化應(yīng)激水平明顯高于正常對(duì)照組氧化應(yīng)激水平。在CKD5D期患者體內(nèi)，維持性血液透析患者血清SOD水平低于維持性腹膜透析患者，MDA水平高于腹膜透析患者，均有統(tǒng)計(jì)學(xué)差異（p0.05）；GSH-Px水平兩組無(wú)統(tǒng)計(jì)學(xué)差異。多因素回歸分析結(jié)果提示：CKD5D期患者體內(nèi)SOD水平與是否服用血管緊張素轉(zhuǎn)化酶抑制劑/血管緊張素II受體拮抗劑（ACEI/ARB）、透析齡、年齡和性別密切相關(guān)。進(jìn)一步亞組分析發(fā)現(xiàn)：病因?yàn)楦哐獕耗I病的CKD5D期患者體內(nèi)SOD水平與是否服用他汀類藥物、年齡和性別有關(guān)，病因?yàn)樘悄虿∧I病的CKD5D期患者體內(nèi)SOD水平與透析齡及年齡有關(guān)，病因?yàn)槁阅I小球腎炎的CKD5D期患者體內(nèi)SOD水平與是否服用他汀類藥物有關(guān)。 結(jié)論： CKD5D期患者體內(nèi)氧化應(yīng)激水平與透析齡、年齡及性別相關(guān)，貧血及炎癥會(huì)加重氧化應(yīng)激水平，維持性血液透析患者體內(nèi)氧化應(yīng)激水平高于維持性腹膜透析患者。
[Abstract]:Objective: To investigate the changes of oxidative stress and related factors in patients with CKD5D nephropathy, and to compare the effects of different renal replacement therapy on the level of oxidative stress in patients with end-stage renal disease.
Methods: the serum levels of CKD5D patients were collected and the levels of serum superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) were measured by double antibody sandwich method. The clinical data of patients were collected and the related factors were analyzed by statistical methods.
Results: the level of oxidative stress in patients with CKD5D was significantly higher than that of the normal control group. In the patients with CKD5D, the serum SOD level of the patients in the maintenance hemodialysis patients was lower than those in the maintenance peritoneal dialysis patients. The level of MDA was higher than that of the peritoneal dialysis patients (P0.05); there was no statistical difference between the two groups of GSH-Px. The regression analysis showed that SOD levels in patients with CKD5D were closely related to the age, age, and sex of the angiotensin converting enzyme inhibitor / angiotensin II receptor antagonist (ACEI/ARB). Further subgroup analysis found that the level of SOD in patients with CKD5D phase of hypertensive nephropathy and whether to take statins or not It is related to age and sex. The level of SOD in patients with phase CKD5D of diabetic nephropathy is related to the age and age of dialysis. The level of SOD in CKD5D patients with chronic glomerulonephritis is related to whether or not to take statins.
Conclusion: the levels of oxidative stress in CKD5D patients are related to age and age, age and sex. Anemia and inflammation may aggravate the level of oxidative stress. The level of oxidative stress in maintenance hemodialysis patients is higher than that of patients with maintenance peritoneal dialysis.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R692.5

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本文編號(hào)：1968639