本文選題：單純性腎囊腫 + 供腎　； 參考：《浙江大學(xué)》2017年碩士論文

【摘要】：目的單純性腎囊腫可能是慢性腎病的早期表現(xiàn)。本研究旨在探討供腎合并單純性腎囊腫是否會(huì)對(duì)活體腎移植受體的預(yù)后產(chǎn)生影響。方法回顧性分析2007年4月-2015年4月在我院腎臟病中心進(jìn)行活體腎移植的716例受體與供體的資料。通過(guò)查看供體術(shù)前腹部增強(qiáng)CT的影像資料,發(fā)現(xiàn)共91例供體有單純性腎囊腫,其中64例供體的供腎側(cè)有腎囊腫。將這64例供腎合并囊腫的受體與供腎無(wú)合并囊腫的受體進(jìn)行1:2匹配,匹配條件依次是供體性別,受體性別,供體術(shù)前血肌酐值,供/受體BSA比值,供體的年齡,受體年齡,及手術(shù)日期。分析兩組受體在術(shù)后隨訪期內(nèi)的移植腎預(yù)后情況。結(jié)果單純性腎囊腫的發(fā)病率與供體的性別、年齡及腎小球?yàn)V過(guò)率值獨(dú)立相關(guān)。根據(jù)供腎零點(diǎn)穿刺病理結(jié)果顯示,供腎囊腫組的腎小球硬化率比供腎無(wú)囊腫組的高(P=0.040)。供腎囊腫組與無(wú)囊腫組的受體在術(shù)后第7天,6月,5年的腎小球?yàn)V過(guò)率比值分別為 80.82±26.61 vs.88.21±23.12,66.95±17.42 vs.72.15±16.42,60.92±22.17vs.68.72±14.43ml/(min·1.73m2)(P0.05)。兩組在術(shù)后第 7 天,6 月的血肌酐比值分別為 112.14±48.32 vs.98.75±29.71,126.28±42.32 vs.115.05±26.35μmol/l(P0.05)。兩組受體的5年移植腎/人生存率無(wú)明顯差異。結(jié)論在活體腎移植中,供腎合并單純性腎囊腫會(huì)影響移植腎早期和長(zhǎng)期的功能。在篩選供體時(shí),腎囊腫需作為考慮因素之一。
[Abstract]:Objective simple renal cyst may be an early manifestation of chronic nephropathy. The purpose of this study was to investigate whether donor kidney complicated with simple renal cysts may have an effect on the prognosis of renal transplant recipients in vivo. Methods from April 2007 to April 2015, 716 recipients and donors of live kidney transplantation in our renal disease center were retrospectively analyzed. A total of 91 donors were found to have simple renal cysts, of which 64 had renal cysts on the donor side. The recipients of these 64 cases were matched at 1:2 with those without cyst of donor kidney. The matching conditions were donor sex, recipient sex, serum creatinine value, donor / receptor BSA ratio, donor age and recipient age. And the date of the operation. To analyze the prognosis of renal allograft in the two groups during the follow-up period. Results the incidence of simple renal cyst was independent of donor sex, age and glomerular filtration rate. The glomerular sclerosis rate in the donor renal cyst group was higher than that in the donor renal cyst group. The ratio of glomerular filtration rate between the donor cysts group and the non-cysts group was 80.82 鹵26.61 vs.88.21 鹵23.12 66.95 鹵17.42 vs.72.15 鹵16.42 鹵60.92 鹵22.17vs.68.72 鹵1.73 m ~ 2 (P 0.05) on the 7th day, 6th month and 5th year after operation, respectively. The serum creatinine ratio of the two groups was 112.14 鹵48.32 vs.98.75 鹵29.71 126.28 鹵42.32 vs.115.05 鹵26.35 渭 mol / L P 0.05 on the 7th day after operation. There was no significant difference in 5-year survival rate between the two groups. Conclusion donor kidney combined with simple renal cysts may affect the early and long term function of donor kidney in living donor kidney transplantation. Renal cyst should be considered as a factor in donor selection.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R699.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 Mahmoud Kamel;Manish Kadian;Titte Srinivas;David Taber;Maria Aurora Posadas Salas;;Tacrolimus confers lower acute rejection rates and better renal allograft survival compared to cyclosporine[J];World Journal of Transplantation;2016年04期

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本文編號(hào)：1959482