本文選題：左卡尼汀 + 維持性血液透析��； 參考：《中國(guó)老年學(xué)雜志》2017年19期

【摘要】：目的探析左卡尼汀(L-CN)對(duì)接受維持性血液透析(MHD)治療的終末期腎病(ESRD)老年患者的微炎癥及貧血、營(yíng)養(yǎng)不良狀態(tài)的影響。方法 MHD治療的54例ESRD老年患者隨機(jī)分成觀察組(L-CN治療)和對(duì)照組(無L-CN治療),分別為26和28例。比較兩組基線資料、炎性因子、營(yíng)養(yǎng)及貧血改善指標(biāo)的表達(dá)水平。結(jié)果治療前兩組各炎性指標(biāo),包括血清白細(xì)胞介素(IL)-6,IL-8,超敏C反應(yīng)蛋白(hs-CRP),腫瘤壞死因子(TNF)-α與脂蛋白[La(a)]水平無顯著差異(P0.05);治療后,對(duì)照組各炎性指標(biāo)水平與治療前無顯著差異(P0.05),而觀察組各炎性指標(biāo)水平較對(duì)照組與治療前均明顯降低(P0.05)。治療前兩組營(yíng)養(yǎng)及貧血指標(biāo),包括血漿白蛋白(Alb)、血細(xì)胞比容(Hct)、血紅蛋白(Hb)、轉(zhuǎn)鐵蛋白(TRF)、血漿總蛋白(TP)及前白蛋白(PAB)的表達(dá)水平無顯著差異(P0.05);治療后,對(duì)照組各指標(biāo)較治療前無顯著差異(P0.05),而觀察組各指標(biāo)較對(duì)照組及治療前均顯著升高(P0.05)。結(jié)論 L-CN治療不但可以顯著改善MHD老年ESRD患者的微炎癥反應(yīng),還可以糾正腎性貧血和營(yíng)養(yǎng)不良的狀態(tài)。
[Abstract]:Objective to investigate the effects of L-CNL on microinflammation, anemia and malnutrition in elderly patients with end-stage renal disease (ESRD) treated with maintenance hemodialysis (MHD). Methods 54 elderly patients with ESRD treated with MHD were randomly divided into two groups: observation group (n = 26) and control group (n = 28). The expression of baseline data, inflammatory factors, nutrition and anemia were compared between the two groups. Results there was no significant difference in the levels of serum IL-8, hs-CRP, TNF- 偽 and lipoprotein between the two groups before treatment, including IL-8, hs-CRP, TNF- 偽 and lipoprotein (Lahua-), after treatment, there was no significant difference between the two groups (P 0.05). There was no significant difference in the levels of inflammatory indexes between the control group and the control group before treatment (P 0.05), but the levels of each inflammatory index in the observation group were significantly lower than those in the control group and before treatment (P 0.05). Before treatment, there was no significant difference in the levels of nutritional and anemia indexes between the two groups, including the expression of plasma albumin Albbumin, HCT, HBC, TRFT, TPTP and PAB.After treatment, there was no significant difference between the two groups (P 0.05), and after treatment, there was no significant difference between the two groups in the expression levels of TRFF, TPTP and PAB.After the treatment, there was no significant difference in the expression levels between the two groups. There was no significant difference in the indexes of the control group compared with that before treatment, but the indexes of the observation group were significantly higher than those of the control group and before treatment. Conclusion the treatment of L-CN can not only improve the microinflammation in MHD elderly patients with ESRD, but also correct renal anemia and malnutrition.
【作者單位】： 海南省農(nóng)墾總醫(yī)院腎內(nèi)科;
【基金】：海南省科學(xué)技術(shù)廳應(yīng)用技術(shù)研發(fā)與示范推廣專項(xiàng)項(xiàng)目(No.ZDXM2015085)
【分類號(hào)】：R692.5

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 楊世明;呂承菲;劉仁香;;左卡尼汀防治血液透析相關(guān)性低血壓的療效觀察[J];現(xiàn)代醫(yī)藥衛(wèi)生;2011年18期

2 袁芳;彭佑銘;朱笑萍;符曉;肖力;;左卡尼汀對(duì)30例維持性血透患者生活質(zhì)量和鐵負(fù)荷的影響[J];臨床內(nèi)科雜志;2007年09期

3 李國(guó)華;李宇丹;丁志勝;胡晏珍;蔡雪;張志文;;復(fù)方氨基酸注射液(9AA)聯(lián)合左卡尼汀對(duì)維持性血液透析高齡患者營(yíng)養(yǎng)狀況的影響[J];實(shí)用醫(yī)學(xué)雜志;2013年09期

4 李放;;左卡尼汀對(duì)血液透析患者貧血治療的臨床觀察[J];中國(guó)現(xiàn)代醫(yī)生;2009年04期

5 李翠霞;田焱林;;左卡尼汀治療維持血液透析患者的臨床觀察[J];中國(guó)民族民間醫(yī)藥;2010年22期

6 許可;;左卡尼汀在血液透析患者中的應(yīng)用觀察[J];醫(yī)藥論壇雜志;2011年01期

7 王開利;邢漢前;劉俊微;趙鴻;姚宏宇;張雪華;趙軍;;血液透析患者應(yīng)用左卡尼汀的療效觀察[J];軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào);2012年12期

8 楊賢;梁培;王娟;張海霞;;左卡尼汀在維持性血液透析中的應(yīng)用進(jìn)展[J];中國(guó)臨床藥理學(xué)雜志;2013年05期

9 王莉華;張麗;王曉玲;;左卡尼汀對(duì)維持性血液透析患者炎癥狀態(tài)的影響[J];臨床薈萃;2009年08期

10 宋宇春;劉永;徐琨;王艷;尚會(huì)強(qiáng);李列寬;;血液透析患者靜脈注射左卡尼汀24例療效觀察[J];貴州醫(yī)藥;2009年07期

相關(guān)會(huì)議論文 前2條

1 張玲;劉桂香;;左卡尼汀在血液透析中應(yīng)用于心衰患者30例臨床效果觀察[A];中華醫(yī)學(xué)會(huì)腎臟病學(xué)分會(huì)2006年學(xué)術(shù)年會(huì)論文集[C];2006年

2 李瑞君;熊芳桂;;促紅細(xì)胞生成素與左卡尼汀注射液對(duì)血液透析患者的影響[A];中華醫(yī)學(xué)會(huì)腎臟病學(xué)分會(huì)2006年學(xué)術(shù)年會(huì)論文集[C];2006年

相關(guān)碩士學(xué)位論文 前1條

1 朱付蓮;左卡尼汀對(duì)維持性血液透析患者臨床治療作用[D];吉林大學(xué);2012年

，

本文編號(hào)：1937051