本文選題：前列腺腫瘤 + 睪酮　； 參考：《中國老年學(xué)雜志》2017年22期

【摘要】：目的探討血清睪酮(T)、空腹胰島素(FINS)水平與前列腺癌(PCa)臨床病理特征的相關(guān)性。方法良性前列腺增生(BPH)組25例和PCa組38例,據(jù)Gleason評分將PCa患者分為兩組(Gleason≤6分組20例和Gleason≥7分組18例)。所有患者術(shù)前檢測血清T、FINS水平;術(shù)后測定活檢及手術(shù)標本的Gleason評分;免疫組化測定胰島素樣生長因子Ⅰ受體(IGF-ⅠR)在前列腺組織中的表達。結(jié)果 PCa組較BPH組血清T水平明顯降低(P0.05),PCa組中Gleason≥7分組較Gleason≤6分組患者血清T水平明顯降低(P0.05)。PCa組較BPH組FINS明顯增高(P0.05);而PCa組中Gleason≥7分組FINS值明顯高于Gleason≤6分組(P0.05)。T與FINS呈明顯負相關(guān)(r=-0.312,均P0.05)。IGF-I R的陽性表達與Pca的Gleason評分無相關(guān)性(P0.05)。結(jié)論 T水平越低,PCa的惡性程度越高;而FINS值越高,前列腺癌Gleason評分越高。
[Abstract]:Objective to investigate the relationship between serum testosterone and fasting insulin (fins) and clinicopathological features of prostate cancer (PCA). Methods 25 patients with benign prostatic hyperplasia (BPH) group and 38 patients with PCa group were divided into two groups according to Gleason score: PCa group (n = 20) and Gleason 鈮，

本文編號：1898578