本文選題：坦索羅辛膠囊 + 多沙唑嗪片　； 參考：《中國臨床藥理學(xué)雜志》2017年24期

【摘要】：目的觀察坦索羅辛膠囊和多沙唑嗪片分別聯(lián)合酒石酸托特羅定緩釋片治療良性前列腺增生伴下尿路癥狀患者的臨床療效和安全性。方法將120例患者隨機分為對照組60例和試驗組60例。對照組予以口服多沙唑嗪4 mg qn和酒石酸托特羅定4 mg qn,4周為1療程,共治療3個療程;試驗組予以口服坦索羅辛0.2 mg qn和酒石酸托特羅定4 mg qn,4周為1療程,共治療3個療程。比較2組患者的臨床療效、國際前列腺癥狀(IPSS)評分、刺激癥狀評分、最大尿流速(Q_(max))、生活質(zhì)量評分(QOL)、膀胱過度活動癥評分(OABSS)、膀胱過度活動癥狀以及藥物不良反應(yīng)發(fā)生率。結(jié)果治療后,試驗組和對照組的總有效率分別為96.67%(58例/60例)和83.33%(50例/60例),差異有統(tǒng)計學(xué)意義(P0.05)。治療后,試驗組和對照組的IPSS評分分別為(14.08±4.52),(17.15±4.34)分,刺激癥狀評分分別為(4.47±1.11),(5.77±1.10)分,Q_(max)分別為(14.15±1.72),(13.21±2.16)mL·s~(-1),QOL評分分別為(1.38±0.99),(3.27±1.39)分,OABSS評分分別為(8.08±2.12),(13.83±4.37)分,日間排尿次數(shù)分別為(7.52±2.21),(8.68±2.00)次,夜尿次數(shù)分別為(1.40±0.76),(2.48±1.48)次,急迫性尿失禁次數(shù)分別為(1.00±0.55),(1.90±0.35)次,尿急次數(shù)分別為(2.58±1.08),(4.53±0.98)次,差異均有統(tǒng)計學(xué)意義(均P0.05)。試驗組和對照組藥物不良反應(yīng)發(fā)生率分別為5.00%(3例/60例)和5.00%(3例/60例),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論坦索羅辛聯(lián)合酒石酸托特羅定治療良性前列腺增生伴下尿路癥狀患者的臨床療效優(yōu)于多沙唑嗪聯(lián)合酒石酸托特羅定方案,安全性高。
[Abstract]:Objective to observe the clinical efficacy and safety of tansoroxin capsule and doxazosin tablet combined with tolterodine tartrate sustained-release tablets in the treatment of benign prostatic hyperplasia with lower urinary tract symptoms. Methods 120 patients were randomly divided into control group (n = 60) and experimental group (n = 60). The control group received oral administration of doxazosin 4 mg QN and tolterodine tartrate 4 mg QN for 4 weeks for 3 courses of treatment, while the experimental group received oral administration of tamsoloxin 0.2 mg QN and tolterodine tartrate 4 mg QNX for 4 weeks as a course of treatment. There were 3 courses of treatment. The clinical efficacy, international prostate symptom IPSS score, stimulation symptom score, maximal urinary flow rate, QOL score, bladder hyperactivity symptom and incidence of adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 96.6767 / 60 and 83.33 / 50 / 60, respectively. The difference was statistically significant (P 0.05). 娌葷枟鍚，

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